Screen-printed electrode for electrochemical detection of sunitinib malate for therapeutic drug monitoring DOI Creative Commons
Arun Warrier,

Pooja Das Manjulabhai,

Aiswarya Rajesh

et al.

Journal of Electrochemical Science and Engineering, Journal Year: 2024, Volume and Issue: unknown

Published: Dec. 10, 2024

Sunitinib is a targeted therapy for colorectal cancer, which needs precise dosage due to potential severe side effects from overdose. Therapeutic drug monitoring crucial maintaining optimal levels in body fluids. Traditional anticancer dose evalua­tion methods such as high-pressure liquid chromatography, chromatography with mass spectrophotometry, and immunoassays are cumbersome. This study explores the utilization of electrochemical sensors on indigenously developed screen-printed electrodes sunitinib malate monitoring. Differential pulse voltammetry, cyclic voltam­metry chrono-amperometric studies were conducted conventional three-elec­trode system. An anodic peak current, indicative electro­oxi­dation, was observed around +0.45 V vs. Ag/AgCl reference electrode 0.1 M PB pH 7.4. Sen­sitivity, limit detection method determined 0.386 µA µM-1 cm-2, 0.009 0.0108 µM, respectively. The response exhibited linearity (R2 = 0.990) concentration ranging 0.08 88 μM good reproducibility. DPV real samples yielded acceptable recovery values. Electro­chemical based present promising approach monitoring, offering sensitivity, low detection, wide linear range. Since expected plasma much higher than sensor range, it can be used sample analysis. Here could simplify improve therapeutic cancer treatment.

Language: Английский

A sensitive electrochemical sensing platform for the detection of Marbofloxacin using ZrMo2O8/MWCNT-COOH composites DOI
Yuan Jin, Tianyu Wang,

Junyuan Song

et al.

Journal of environmental chemical engineering, Journal Year: 2025, Volume and Issue: unknown, P. 115629 - 115629

Published: Jan. 1, 2025

Language: Английский

Citations

1
Innovative MOF-Enhanced Electroanalytical Approach for Sensitive Sunitinib Malate Detection in Renal Carcinoma Patients Using CuO/Lanthanum MOF-Modified Carbon Paste Electrode DOI Creative Commons
Azza H. Rageh,

Mohamed I. Said,

Asmaa Abdeltawab

et al.

Talanta Open, Journal Year: 2025, Volume and Issue: unknown, P. 100404 - 100404

Published: Jan. 1, 2025

Language: Английский

Citations

0
Development of metal oxide Nanocomposite-Coated electrospun nanofibers for highly sensitive xanthine monitoring DOI

Shanza Anzar,

Sehrish Hanif,

Ibrahim A. Shaaban

et al.

Microchemical Journal, Journal Year: 2024, Volume and Issue: unknown, P. 112001 - 112001

Published: Oct. 1, 2024

Language: Английский

Citations

3
Screen-printed electrode for electrochemical detection of sunitinib malate for therapeutic drug monitoring DOI Creative Commons
Arun Warrier,

Pooja Das Manjulabhai,

Aiswarya Rajesh

et al.

Journal of Electrochemical Science and Engineering, Journal Year: 2024, Volume and Issue: unknown

Published: Dec. 10, 2024

Sunitinib is a targeted therapy for colorectal cancer, which needs precise dosage due to potential severe side effects from overdose. Therapeutic drug monitoring crucial maintaining optimal levels in body fluids. Traditional anticancer dose evalua­tion methods such as high-pressure liquid chromatography, chromatography with mass spectrophotometry, and immunoassays are cumbersome. This study explores the utilization of electrochemical sensors on indigenously developed screen-printed electrodes sunitinib malate monitoring. Differential pulse voltammetry, cyclic voltam­metry chrono-amperometric studies were conducted conventional three-elec­trode system. An anodic peak current, indicative electro­oxi­dation, was observed around +0.45 V vs. Ag/AgCl reference electrode 0.1 M PB pH 7.4. Sen­sitivity, limit detection method determined 0.386 µA µM-1 cm-2, 0.009 0.0108 µM, respectively. The response exhibited linearity (R2 = 0.990) concentration ranging 0.08 88 μM good reproducibility. DPV real samples yielded acceptable recovery values. Electro­chemical based present promising approach monitoring, offering sensitivity, low detection, wide linear range. Since expected plasma much higher than sensor range, it can be used sample analysis. Here could simplify improve therapeutic cancer treatment.

Language: Английский

Citations

0