Introducing the Role of Genotoxicity in Neurodegenerative Diseases and Neuropsychiatric Disorders DOI Open Access
Glen E. Kisby,

David M. Wilson,

Peter S. Spencer

et al.

International Journal of Molecular Sciences, Journal Year: 2024, Volume and Issue: 25(13), P. 7221 - 7221

Published: June 29, 2024

Decades of research have identified genetic and environmental factors involved in age-related neurodegenerative diseases and, to a lesser extent, neuropsychiatric disorders. Genomic instability, i.e., the loss genome integrity, is common feature among both (mayo-trophic lateral sclerosis, Parkinson's disease, Alzheimer's disease) psychiatric (schizophrenia, autism, bipolar depression) instability associated with accumulation persistent DNA damage activation response (DDR) pathways, as well pathologic neuronal cell or senescence. Typically, DDR signaling ensures that genomic proteomic homeostasis are maintained dividing cells, including neural progenitors, post-mitotic neurons. However, dysregulation these protective responses, part due aging insults, contributes progressive development and/or In this Special Issue, we introduce highlight overlap between disorders, emerging clinical, genomic, molecular evidence for contributions aberrant repair. Our goal illuminate importance subject uncover possible treatment prevention strategies relevant devastating brain diseases.

Language: Английский

The Relationship between Stress, Inflammation, and Depression DOI Creative Commons
Il Bin Kim, Jae-Hon Lee, Seon‐Cheol Park

et al.

Biomedicines, Journal Year: 2022, Volume and Issue: 10(8), P. 1929 - 1929

Published: Aug. 9, 2022

A narrative review about the relationship between stress, inflammation, and depression is made as follows: Chronic stress leads to various stress-related diseases such depression. Although most human are related exposure, common pathways pathophysiological processes of different disorders still debatable. inflammation a crucial component chronic diseases, including Both experimental clinical studies have demonstrated that an increase in levels pro-inflammatory cytokines hormones, glucocorticoids, substantially contributes behavioral alterations associated with Evidence suggests plays key role pathology diseases; however, this link has not yet been completely explored. In study, we aimed determine stress-induced whether pathway for exists. Recent support pharmacological non-pharmacological treatment approaches significantly ameliorating depression-related inflammation. addition, major can be activated immune system, whereas antidepressants exert immunomodulatory effects. Moreover, treatments (i.e., exercise) may mediated by anti-inflammatory actions. This highlights mechanisms underlying provides new insights into prevention particularly

Language: Английский

Citations

61
The Influence of Vicarious Fear-Learning in “Infecting” Reactive Action Inhibition DOI Creative Commons
Simone Battaglia, Pasquale Cardellicchio, Chiara Di Fazio

et al.

Frontiers in Behavioral Neuroscience, Journal Year: 2022, Volume and Issue: 16

Published: July 22, 2022

Since the dawn of cognitive neuroscience, emotions have been recognized to impact on several executive processes, such as action inhibition. However, complex interplay between emotional stimuli and control is not yet fully understood. One way measure inhibitory stop-signal task (SST), which estimates ability cancel outright an presentation a stop signal by means reaction times (SSRTs). Impaired well facilitated has found when faced with intrinsic signals in SSTs. Here, we aimed at investigating more deeply power negative influence our control, testing hypothesis that previously neutral stimulus [i.e., image severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2)], conditioned through vicarious fear learning, same reactive inhibition performance intrinsically (i.e., fearful face or body). Action capabilities were tested 90 participants SST, represented different stimuli. Results showed SARS-CoV-2 enhanced suppress ongoing similarly observing facial expressions body postures. Interestingly, this effect was predicted impulsivity traits: for example, less self-control had, they facilitation performance. These results demonstrated learning critical abilities, making threatening phylogenetically innate able behavioral control.

Language: Английский

Citations

54
Integrating Armchair, Bench, and Bedside Research for Behavioral Neurology and Neuropsychiatry: Editorial DOI Creative Commons
Masaru Tanaka, Ágnes Szabó, László Vécsei

et al.

Biomedicines, Journal Year: 2022, Volume and Issue: 10(12), P. 2999 - 2999

Published: Nov. 22, 2022

"To learning much inclined, who went to see the Elephant (though all of them were blind) that each by observation might satisfy mind" [...].

Language: Английский

Citations

51
From CGRP to PACAP, VIP, and Beyond: Unraveling the Next Chapters in Migraine Treatment DOI Creative Commons
Masaru Tanaka, Ágnes Szabó, Tamás Körtési

et al.

Cells, Journal Year: 2023, Volume and Issue: 12(22), P. 2649 - 2649

Published: Nov. 17, 2023

Migraine is a neurovascular disorder that can be debilitating for individuals and society. Current research focuses on finding effective analgesics management strategies migraines by targeting specific receptors neuropeptides. Nonetheless, newly approved calcitonin gene-related peptide (CGRP) monoclonal antibodies (mAbs) have 50% responder rate ranging from 27 to 71.0%, whereas CGRP receptor inhibitors 56 71%. To address the need novel therapeutic targets, researchers are exploring potential of another secretin family peptide, pituitary adenylate cyclase-activating polypeptide (PACAP), as ground-breaking treatment avenue migraine. Preclinical models revealed how PACAP affects trigeminal system, which implicated in headache disorders. Clinical studies demonstrated significance migraine pathophysiology; however, few clinical trials remain inconclusive: 1 mAb, AMG 301 showed no benefit prevention, while ligand Lu AG09222 significantly reduced number monthly days over placebo phase 2 trial. Meanwhile, vasoactive intestinal (VIP) gaining interest new target. In light recent advances research, we emphasize promising target treatment, highlighting member antimigraine armamentarium, especially patients who do not respond or contraindicated anti-CGRP therapies. By updating our knowledge its unique contribution pathophysiology, pave way reinforcing other peptides, including VIP, option migraines.

Language: Английский

Citations

40
Editorial: Case reports in neuroimaging and stimulation DOI Creative Commons
Simone Battaglia, André Schmidt, Stefanie Hassel

et al.

Frontiers in Psychiatry, Journal Year: 2023, Volume and Issue: 14

Published: Aug. 2, 2023

EDITORIAL article Front. Psychiatry, 02 August 2023Sec. Neuroimaging Volume 14 - 2023 | https://doi.org/10.3389/fpsyt.2023.1264669

Language: Английский

Citations

38
Editorial: Insights into structural and functional organization of the brain: evidence from neuroimaging and non-invasive brain stimulation techniques DOI Creative Commons
Masaru Tanaka, Matteo Diano, Simone Battaglia

et al.

Frontiers in Psychiatry, Journal Year: 2023, Volume and Issue: 14

Published: June 12, 2023

EDITORIAL article Front. Psychiatry, 12 June 2023Sec. Neuroimaging Volume 14 - 2023 | https://doi.org/10.3389/fpsyt.2023.1225755

Language: Английский

Citations

37
Exercise for Mental Well-Being: Exploring Neurobiological Advances and Intervention Effects in Depression DOI Creative Commons
Jianchang Ren, Haili Xiao

Life, Journal Year: 2023, Volume and Issue: 13(7), P. 1505 - 1505

Published: July 4, 2023

Depression is a common mental disorder in which patients often experience feelings of sadness, fatigue, loss interest, and pleasure. Exercise widely used intervention for managing depression, but the specific molecular mechanisms underlying its antidepressant effect are unclear. In this narrative review, we aim to synthesize current knowledge on molecular, neural, physiological through exercise exerts discuss various interventions depression. We conducted review literature topic Our suggests that impacts peripheral tryptophan metabolism, central inflammation, brain-derived neurotrophic factors peroxisome proliferator-activated receptor γ activating factor 1α (PGC-1α) skeletal muscles. The uncarboxylated osteocalcin facilitates "bone-brain crosstalk", corrects atypical expression brain-gut peptides, modulates cytokine production neurotransmitter release, regulates inflammatory pathways microRNA expression. Aerobic recommended at frequencies 3 5 times per week with medium high intensity. Here highlight significant potential therapy supported by effect. Understanding neural involved exercise's opens new avenues developing novel therapies

Language: Английский

Citations

28
Unraveling the pathophysiology of schizophrenia: insights from structural magnetic resonance imaging studies DOI Creative Commons
Mohammed Jajere Adamu, Qiang Li, Charles Okanda Nyatega

et al.

Frontiers in Psychiatry, Journal Year: 2023, Volume and Issue: 14

Published: May 19, 2023

Background Schizophrenia affects about 1% of the global population. In addition to complex etiology, linking this illness genetic, environmental, and neurobiological factors, dynamic experiences associated with disease, such as delusions, hallucinations, disorganized thinking, abnormal behaviors, limit neurological consensuses regarding mechanisms underlying disease. Methods study, we recruited 72 patients schizophrenia 74 healthy individuals matched by age sex investigate structural brain changes that may serve prognostic biomarkers, indicating evidence neural dysfunction subsequent cognitive behavioral deficits. We used voxel-based morphometry (VBM) determine these in three tissue structures: gray matter (GM), white (WM), cerebrospinal fluid (CSF). For both image processing statistical analysis, parametric mapping (SPM). Results Our results show exhibited a significant volume reduction GM WM. particular, reductions were more evident frontal, temporal, limbic, parietal lobe, similarly WM predominantly limbic lobe. addition, demonstrated increase CSF left third lateral ventricle regions. Conclusion This VBM study supports existing research showing is alterations structure, including matter, volume. These findings provide insights into neurobiology inform development effective diagnostic therapeutic approaches.

Language: Английский

Citations

23
Disentangling the role of gray matter volume and concentration in autism spectrum disorder: A meta-analytic investigation of 25 years of voxel-based morphometry research DOI Creative Commons
Donato Liloia, Denisa Adina Zamfira, Masaru Tanaka

et al.

Neuroscience & Biobehavioral Reviews, Journal Year: 2024, Volume and Issue: 164, P. 105791 - 105791

Published: July 2, 2024

Despite over two decades of neuroimaging research, a unanimous definition the pattern structural variation associated with autism spectrum disorder (ASD) has yet to be found. One potential impeding issue could sometimes ambiguous use measurements variations in gray matter volume (GMV) or concentration (GMC). In fact, while both can calculated using voxel-based morphometry analysis, these may reflect different underlying pathological mechanisms. We conducted coordinate-based meta-analysis, keeping apart GMV and GMC studies subjects ASD. Results showed distinct non-overlapping patterns for measures. decreases were evident cerebellum, mainly found temporal frontal regions. increases parietal, temporal, brain regions, observed anterior cingulate cortex middle gyrus. Age-stratified analyses suggested that such are dynamic across ASD lifespan. The present findings emphasize importance considering as synergistic indices research.

Language: Английский

Citations

11
Revolutionizing our understanding of Parkinson’s disease: Dr. Heinz Reichmann’s pioneering research and future research direction DOI Creative Commons
Masaru Tanaka, László Vécsei

Journal of Neural Transmission, Journal Year: 2024, Volume and Issue: 131(12), P. 1367 - 1387

Published: Aug. 7, 2024

Millions of individuals around the world are afflicted with Parkinson's disease (PD), a prevalent and incapacitating neurodegenerative disorder. Dr. Reichmann, distinguished professor neurologist, has made substantial advancements in domain PD research, encompassing both fundamental scientific investigations practical applications. His research illuminated etiology treatment PD, as well function energy metabolism premotor symptoms. As precursor to number neurotransmitters neuromodulators that implicated pathophysiology he also investigated application tryptophan (Trp) derivatives disease. principal findings insights summarized synthesized this narrative review article, which emphasizes challenges implications for future research. This aims identify analyze key contributions Reichmann field ultimate goal informing directions domain. By examining Reichmann's work, study seeks provide comprehensive understanding his major how they can be applied advance diagnosis PD. paper explores potential intersection emerging avenues, such investigation Trp its metabolites, particularly kynurenines, could lead new therapeutic strategies managing disorders like

Language: Английский

Citations

10