Frontiers in Cell and Developmental Biology,
Journal Year:
2025,
Volume and Issue:
13
Published: May 16, 2025
Although
the
role
of
proline
(Pro)
in
regulatory
mechanisms
cell
metabolism
is
well
recognized,
interest
metabolic
significance
hydroxyproline
(Hyp)
has
received
little
attention.
Hyp
was
considered
as
a
waste
metabolite
protein
degradation,
mainly
degradation
collagen.
This
amino
acid
not
synthesized
de
novo
and
incorporated
into
proteins.
product
Pro
hydroxylation
proteins
by
specific
hydroxylase.
Therefore,
derived
from
proteins,
it
further
metabolized
dehydrogenase
2
(PRODH2),
known
also
oxidase
(OH-POX).
The
enzyme
catalyzes
conversion
Δ
1
-pyrroline-3-OH-5-carboxylic
(OH-P5C),
yielding
electrons
that
are
used
electron
transport
chain
for
ATP
production.
However,
certain
conditions
accepted
oxygen
forming
reactive
species
(ROS).
product,
OH-P5C
could
be
converted
reductase
to
recycle
NADP
+
pentose
phosphate
pathway
(PPP),
nucleotides
DNA
synthesis.
Interestingly,
hydroxylase
requires
same
cofactors
(α-KG,
ascorbate
Fe
2+
)
histone
demethylases,
suggesting
epigenetic
regulation.
highly
energetic
acid,
glycine
(Gly).
Of
great
importance
upregulation
transcriptional
activity
hypoxia-inducible
factor
1α
(HIF-1α),
inducing
angiogenesis
metastasis.
involved
several
critical
processes
regulating
synthesis,
gene
expression,
apoptosis/survival,
angiogenesis,
metastasis
energy
production,
key
reprogramming
cancer
cells.
It
suggests
target
novel
experimental
strategy
treatment.
Foods,
Journal Year:
2025,
Volume and Issue:
14(6), P. 950 - 950
Published: March 11, 2025
(1)
Background:
Thermal
stress
in
Guangdong's
tropical/subtropical
regions
significantly
compromises
yolk
quality
Huaixiang
chickens.
Canthaxanthin
(CX),
an
effective
feed
additive,
has
been
demonstrated
to
not
only
enhance
the
nutritional
composition
of
egg
yolks
but
also
mitigate
heat
stress.
This
study
systematically
evaluates
effects
dietary
CX
supplementation
on
production
rate
and
components
(e.g.,
amino
acids,
lipids,
vitamin
B2)
hens
under
both
normal
high-temperature
environments.
(2)
Methods:
A
factorial
design
was
implemented,
exposing
either
thermoneutral
(25
±
2
°C,
65-75%
RH)
or
(32
conditions.
Diets
were
supplemented
with
graded
levels
(0,
4,
6,
8,
10
mg/kg)
for
9
weeks.
Laying
performance
profiles
(amino
minerals,
evaluated
at
3-week
intervals
(3rd,
6th,
9th
(3)
Results:
Under
temperature
conditions,
addition
enhanced
laying
rate,
relative
weight,
color
score,
lecithin
(LEC)
content,
it
optimized
acid
profile
yolk.
weight
ratio,
total
triglyceride
(TG),
LEC,
B2
(VB2)
chickens
all
decreased.
However,
conditions
effectively
mitigated
these
adverse
effects:
restored
observed
while
TG,
cholesterol
(TC),
high-density
lipoprotein
(HDL-C),
low-density
(LDL-C),
calcium
(Ca),
VB2
higher
than
those
heat-stressed
control
group.
Additionally,
improved.
(4)
Conclusion:
enhances
nutrient
content
providing
a
valuable
reference
healthy
high-quality
eggs.
Foods,
Journal Year:
2025,
Volume and Issue:
14(8), P. 1324 - 1324
Published: April 11, 2025
The
unique
geographical
environment
of
karst
regions
provides
pickles
with
a
favorable
flavor
and
taste;
however,
the
contribution
microbial
community
to
pickle
fermentation
has
not
been
fully
explored.
In
this
study,
high-throughput
sequencing
untargeted
metabolomics
were
used
characterize
60
naturally
fermented
samples
from
12
different
regions.
bacterial
communities
metabolites
changed
significantly
between
Lactobacillus
delbrueckii,
L.
homohiochii,
fermentum
dominant
species
in
samples,
relative
abundances
29.66,
8.05,
7.12%,
respectively.
There
exist
significant
variations
core
biomarkers
traditional
across
diverse
characterized
by
rocky
desertification
varying
temperatures.
Both
homohiochii
buchneri
stimulated
complicated
interspecies
interactions
community.
exhibit
excellent
inhibitory
effects
against
harmful
populations
under
E-low-
E-high-temperature
conditions.
total,
1976
identified
pickles,
including
many
previously
undiscovered
(e.g.,
Citrulline,
GABA,
tyrosol,
L-hydroxyroline)
attributable
dominances
brevis,
buchneri,
plantarum.
Lower
levels
biogenic
amines
found
low-temperature
Furthermore,
delbrueckii
negatively
(p
<
0.05)
correlated
spermine
tyramine,
Weissella
cibaria
was
histamine.
These
data
indicated
that
may
be
beneficial
pickles.
This
work
new
insights
into
resulting
geological
distribution
flora
Poultry Science,
Journal Year:
2025,
Volume and Issue:
unknown, P. 105163 - 105163
Published: April 1, 2025
Global
interest
has
emerged
in
implementing
low
crude
protein
(LCP)
diets
for
poultry.
The
necessity
of
their
development
stems
from
low-cost
formulation,
maintaining
egg
quality,
and
environmental
impacts,
including
health
welfare
concerns
current
production
the
world.
Researchers
have
conducted
several
studies
to
provide
biochemical
insights
into
effect
LCP
on
laying
hen
diets,
but
practical
limitations
still
exist.
Supplementing
feed
with
crystalline
essential
amino
acids
(AAs)
like
methionine,
lysine,
threonine
is
standard
industry
practice.
It
enabled
a
reduction
dietary
(CP)
level.
However,
research
considering
nonessential
AAs
glycine
(Gly)
limited.
Therefore,
this
review
aims
enhance
understanding
hens,
focusing
Gly.
Gly
equivalents
(Glyequi)
represented
first-limiting
acid
poultry
diets.
Targeted
adjustment
Glyequi
can
considerably
decrease
CP
generally
considered
AA
it
becomes
conditionally
under
situations.
variable
requirement
suggested
that
its
static
recommendation
provides
high
safety
margins
These
recommendations
would
help
optimize
albumin
quality
reduce
nitrogen
(N)
emissions
farms.
suggests
could
be
hens
fed
Frontiers in Cell and Developmental Biology,
Journal Year:
2025,
Volume and Issue:
13
Published: May 16, 2025
Although
the
role
of
proline
(Pro)
in
regulatory
mechanisms
cell
metabolism
is
well
recognized,
interest
metabolic
significance
hydroxyproline
(Hyp)
has
received
little
attention.
Hyp
was
considered
as
a
waste
metabolite
protein
degradation,
mainly
degradation
collagen.
This
amino
acid
not
synthesized
de
novo
and
incorporated
into
proteins.
product
Pro
hydroxylation
proteins
by
specific
hydroxylase.
Therefore,
derived
from
proteins,
it
further
metabolized
dehydrogenase
2
(PRODH2),
known
also
oxidase
(OH-POX).
The
enzyme
catalyzes
conversion
Δ
1
-pyrroline-3-OH-5-carboxylic
(OH-P5C),
yielding
electrons
that
are
used
electron
transport
chain
for
ATP
production.
However,
certain
conditions
accepted
oxygen
forming
reactive
species
(ROS).
product,
OH-P5C
could
be
converted
reductase
to
recycle
NADP
+
pentose
phosphate
pathway
(PPP),
nucleotides
DNA
synthesis.
Interestingly,
hydroxylase
requires
same
cofactors
(α-KG,
ascorbate
Fe
2+
)
histone
demethylases,
suggesting
epigenetic
regulation.
highly
energetic
acid,
glycine
(Gly).
Of
great
importance
upregulation
transcriptional
activity
hypoxia-inducible
factor
1α
(HIF-1α),
inducing
angiogenesis
metastasis.
involved
several
critical
processes
regulating
synthesis,
gene
expression,
apoptosis/survival,
angiogenesis,
metastasis
energy
production,
key
reprogramming
cancer
cells.
It
suggests
target
novel
experimental
strategy
treatment.
