Study of ACE and RAGE Genes Polymorphism in Children with Type 1 Diabetes Presented by Renal Complications DOI Creative Commons

Maha Atef Tawfik,

Marwa Said Tawfik El-Sharawy,

Naglaa Fathy Barsem

et al.

Menoufia Medical Journal, Journal Year: 2023, Volume and Issue: 36(3)

Published: Dec. 26, 2023

Objectives: To study the relation between angiotensin I converting enzyme (ACE) and receptor for advanced glycation end products (RAGE) genes in children with type 1 diabetes presented by renal complications. Background: In patients diabetes, an association has been found insertion/deletion (I/D) polymorphism gene ACE presence of diabetic nephropathy. Methods: A cross section was conducted on 50 Egyptian complications from our endocrinology, genetic unit outpatient clinic pediatric department, Menoufia University, during a period time April 2021 to October 2022. Results: there significant difference cases control groups regarding its alleles, (P0.05). Conclusion: Our concluded that ID can markedly increase incidence diabetes-related end-stage disease. data suggests interact modulating progression nephropathy individual risk being fast progressor patients.

Language: Английский

Study of ACE and RAGE Genes Polymorphism in Children with Type 1 Diabetes Presented by Renal Complications DOI Creative Commons

Maha Atef Tawfik,

Marwa Said Tawfik El-Sharawy,

Naglaa Fathy Barsem

et al.

Menoufia Medical Journal, Journal Year: 2023, Volume and Issue: 36(3)

Published: Dec. 26, 2023

Objectives: To study the relation between angiotensin I converting enzyme (ACE) and receptor for advanced glycation end products (RAGE) genes in children with type 1 diabetes presented by renal complications. Background: In patients diabetes, an association has been found insertion/deletion (I/D) polymorphism gene ACE presence of diabetic nephropathy. Methods: A cross section was conducted on 50 Egyptian complications from our endocrinology, genetic unit outpatient clinic pediatric department, Menoufia University, during a period time April 2021 to October 2022. Results: there significant difference cases control groups regarding its alleles, (P0.05). Conclusion: Our concluded that ID can markedly increase incidence diabetes-related end-stage disease. data suggests interact modulating progression nephropathy individual risk being fast progressor patients.

Language: Английский

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