Roles of small peptides encoded by non-coding RNAs in tumor invasion and migration DOI Creative Commons
Jie Liu,

Xiyue Chang,

Laeeqa Manji

et al.

Frontiers in Pharmacology, Journal Year: 2024, Volume and Issue: 15

Published: Sept. 16, 2024

Non-coding RNAs (ncRNAs), which are usually considered not to encode proteins, widely involved in important activities including signal transduction and cell proliferation. However, recent studies have shown that small peptides encoded by ncRNAs (SPENs) roles the development of malignant tumors. Some SPENs participate regulation skeleton reorganization, intercellular adhesion, signaling other processes tumor cells, with effects on invasive migratory abilities cells. Therefore, potential applications as therapeutic targets biomarkers Invasion migration cells main reasons for poor prognosis cancer patients represent most challenging aspects treatment Currently, treatments tumors include surgery, radiotherapy, targeted drug therapy. Surgery, however, is reserved early stages carries risks costs. Radiotherapy therapy serious side effects. This review describes mechanisms their invasion migration, aim providing new diagnosis treatment.

Language: Английский

CircRNA and lncRNA-encoded peptide in diseases, an update review DOI Creative Commons
Qian Yi,

Jianguo Feng,

Weiwu Lan

et al.

Molecular Cancer, Journal Year: 2024, Volume and Issue: 23(1)

Published: Sept. 30, 2024

Language: Английский

Citations

15
Noncoding RNA-encoded peptides in cancer: biological functions, posttranslational modifications and therapeutic potential DOI Creative Commons

Shiming Tan,

Wenjuan Yang, Zongyao Ren

et al.

Journal of Hematology & Oncology, Journal Year: 2025, Volume and Issue: 18(1)

Published: Feb. 19, 2025

In the present era, noncoding RNAs (ncRNAs) have become a subject of considerable scientific interest, with peptides encoded by ncRNAs representing particularly promising avenue investigation. The identification ncRNA-encoded in human cancers is increasing. These regulate cancer progression through multiple molecular mechanisms. Here, we delineate patterns diverse and provide synopsis methodologies employed for that possess capacity to encode these peptides. Furthermore, discuss impacts on biological behavior cells underlying conclusion, describe prospects challenges need be overcome.

Language: Английский

Citations

0
Beyond the Transcript: Translating Non-Coding RNAs and Their Impact on Cellular Regulation DOI Open Access
Ananya Deshpande,

Sagar Mahale,

Chandrasekhar Kanduri

et al.

Cancers, Journal Year: 2025, Volume and Issue: 17(9), P. 1555 - 1555

Published: May 3, 2025

Non-coding RNAs (ncRNAs) constitute the majority of human transcriptome and play diverse structural, catalytic, regulatory roles. The ability ncRNAs to be translated into functional peptides microproteins expands our understanding their potential beyond established non-coding functions. Our comprehensive search identified 86 translating “non-coding” RNAs. While have traditionally been categorized as “peptide-encoding”, in this study, we introduce a novel classification based on amino acid length, distinguishing products ncRNA encoded (ncRNA-PEPs), which are less than 60 acids, or (ncRNA-MPs) ranging from 61 200 acids. These act co-regulators cell signaling, transcriptional regulation, protein complex assembly, playing role both health disease. We outline molecular pathways by ncRNA-PEPs ncRNA-MPs could govern cycle progression, highlighting influence transitions, oncogenic tumor suppressor pathways, metabolic homeostasis, autophagy, key regulators like PCNA, Rad18, CDK–cyclin complexes. Furthermore, highlight recent advancements detection characterization, exploring evolutionary origins, species-specific conservation, therapeutic applications. findings underscore emerging significance integral cellular processes, versatility opening promising avenues for further research

Language: Английский

Citations

0
Roles of small peptides encoded by non-coding RNAs in tumor invasion and migration DOI Creative Commons
Jie Liu,

Xiyue Chang,

Laeeqa Manji

et al.

Frontiers in Pharmacology, Journal Year: 2024, Volume and Issue: 15

Published: Sept. 16, 2024

Non-coding RNAs (ncRNAs), which are usually considered not to encode proteins, widely involved in important activities including signal transduction and cell proliferation. However, recent studies have shown that small peptides encoded by ncRNAs (SPENs) roles the development of malignant tumors. Some SPENs participate regulation skeleton reorganization, intercellular adhesion, signaling other processes tumor cells, with effects on invasive migratory abilities cells. Therefore, potential applications as therapeutic targets biomarkers Invasion migration cells main reasons for poor prognosis cancer patients represent most challenging aspects treatment Currently, treatments tumors include surgery, radiotherapy, targeted drug therapy. Surgery, however, is reserved early stages carries risks costs. Radiotherapy therapy serious side effects. This review describes mechanisms their invasion migration, aim providing new diagnosis treatment.

Language: Английский

Citations

2