Italian Consensus on the treatment of oral lichen planus

Italian Journal of Dermatology and Venereology, Journal Year: 2025, Volume and Issue: 160(2)

Published: April 1, 2025

Oral lichen planus (OLP) is a chronic inflammatory condition of uncertain etiology affecting oral mucosae by T-cell mediated inflammation. It affects between 1% and 3% the global population, predominantly middle-aged adults (50-60 years), with higher incidence in women. The immune response thought to target keratinocytes, leading cell death, particularly through CD8+ T lymphocytes. OLP manifests various clinical forms, such as reticular, papular, erosive, atrophic, reticular subtype being most common. Erosive severe, characterized widespread erosions, while atrophic often follows erosive stages, tongue depapillated surface. Currently, no curative treatment exists for OLP, management focuses on symptom relief, including reducing pain discomfort. Thus, multidisciplinary approach involving dermatologists, surgeons, dentists required. For this reason, scientific community represented Italy Mucosal Diseases Study Group SIDeMaST (Italian Society Dermatology Venereology) reports its experience providing recommendations dermatologists based latest evidence optimize OLP.

Language: Английский

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Association between oral lichen planus and Candida albicans infection: a systematic review and meta-analysis

American Journal of Translational Research, Journal Year: 2024, Volume and Issue: 16(8), P. 3462 - 3471

Published: Jan. 1, 2024

This study examines the potential association between Oral Lichen Planus (OLP) and Candida albicans infection, exploring its impact on development of OLP. A meta-analysis individual case-control studies was performed, estimating odds ratios (ORs) their corresponding 95% confidence intervals (CIs). quality assessment literature conducted using Newcastle-Ottawa Scale (NOS). Due to considerable heterogeneity in selected studies, subgroup analyses were performed based geographical location recruitment methods. No significant publication bias detected. sensitivity analysis validated robustness findings when applying a random-effects model. The included ten comprising 1,124 OLP patients 1,063 healthy controls. Results indicated significantly higher detection rate compared controls (OR = 1.74, P 0.003, CI: 1.20, 2.52). Additionally, an increased risk infection observed erosive (E-OLP) 3.97, 2.31, 6.84, < 0.00001). These suggest complex interplay albicans, highlighting need for further research elucidate varying susceptibilities among different clinical types provides novel insights future directions treatment strategies this field.

Language: Английский

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Glycyrrhizin alleviates the toxicity of hydroxychloroquine in treating oral lichen planus by occupying heat shock protein 90 alpha

Phytomedicine, Journal Year: 2024, Volume and Issue: 135, P. 156059 - 156059

Published: Sept. 26, 2024

Language: Английский

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Perturbed saliva microbiome is gender-specific in patients with oral lichen planus

Microbial Pathogenesis, Journal Year: 2024, Volume and Issue: 197, P. 107066 - 107066

Published: Oct. 22, 2024

Language: Английский

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Letter About the Article “Hydroxychloroquine Is Effective in Oral Lichen Planus”

Oral Diseases, Journal Year: 2024, Volume and Issue: unknown

Published: Nov. 6, 2024

Upon meticulous review of the study by Yulang Xie et al., we acknowledge their conclusion that hydroxychloroquine is safe and effective in treating atrophic/erosive/ulcerative oral lichen planus (OLP), demonstrating similar efficacy to topical application 0.05% clobetasol. This finding holds significant clinical relevance (Xie al. 2024). However, believe there are several potential issues within may affect interpretation results. Firstly, does not clarify whether drug-induced lichenoid lesions extra-oral manifestations were excluded (Zeng 2023). Drug-induced might respond differently because distinct pathomechanisms presentations. If with lower responsiveness included study, it could lead an underestimation drug's efficacy. Conversely, if well treatment, this inadvertently overestimate therapeutic effect. Moreover, these excluded, impact safety assessment hydroxychloroquine, as be interactions increase risk adverse reactions. Extra-oral differ manifestation treatment response compared intra-oral lesions. Their inclusion without exclusion disease severity monitoring efficacy, they therapy. Secondly, specify exact locations on buccal mucosa, tongue, or both (Xiong 2009), which limit a comprehensive understanding disease's extent. The distribution OLP across different sites related symptoms impairment function, require varying approaches drug concentrations. lack detailed documentation lesion thorough outcomes. Additionally, mention food intake was recorded baseline metric (Kengtong, Piboonratanakit, Krisdapong 2023; Samimi 2020). Documentation impaired crucial for assessing patient's quality life condition. absence data point suggests have fully captured patients' daily lives, particularly regarding diet nutrition. Improvement after only indicates mitigation but also reflects enhancement life. Therefore, recording In summary, although results al.'s encouraging, further in-depth analysis resolution aforementioned would contribute credibility validity research conclusions. W.-Z. Tang responsible organization coordination trial. X.-B. Chen T.-H. Liu chief investigators analysis. developed trail design. All authors contributed writing final manuscript. There no individuals groups thank study. declare conflicts interest.

Language: Английский

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Lichen planus—the role of age and gender in clinical appearance and treatment

Wiener Medizinische Wochenschrift, Journal Year: 2024, Volume and Issue: unknown

Published: Nov. 12, 2024

Language: Английский

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