Galectins and Liver Diseases
International Journal of Molecular Sciences,
Journal Year:
2025,
Volume and Issue:
26(2), P. 790 - 790
Published: Jan. 18, 2025
Galectins
are
widely
distributed
throughout
the
animal
kingdom,
from
marine
sponges
to
mammals.
a
family
of
soluble
lectins
that
specifically
recognize
β-galactoside-containing
glycans
and
categorized
into
three
subgroups
based
on
number
function
their
carbohydrate
recognition
domains
(CRDs).
The
interaction
galectins
with
specific
ligands
mediates
wide
range
biological
activities,
depending
cell
type,
tissue
context,
expression
levels
individual
galectin,
receptor
involvement.
affect
various
immune
processes
through
both
intracellular
extracellular
mechanisms
play
roles
in
processes,
such
as
apoptosis,
angiogenesis,
fibrosis.
Their
importance
has
increased
recent
years
because
they
recognized
biomarkers,
therapeutic
agents,
drug
targets,
many
other
applications
conditions
cardiovascular
diseases
cancer.
However,
little
is
known
about
involvement
liver
diseases.
Here,
we
review
functions
evaluate
Language: Английский
The sweet and the bitter sides of galectin-1 in immunity: its role in immune cell functions, apoptosis, and immunotherapies for cancer with a focus on T cells
Seminars in Immunopathology,
Journal Year:
2025,
Volume and Issue:
47(1)
Published: April 3, 2025
Galectin-1
(Gal-1),
a
member
of
the
β-galactoside-binding
soluble
lectin
family,
is
double-edged
sword
in
immunity.
On
one
hand,
it
plays
crucial
role
regulating
diverse
immune
cell
functions,
including
apoptosis
activated
T
cells.
These
processes
are
key
resolving
inflammation
and
preventing
autoimmune
diseases.
other
Gal-1
has
significant
implications
cancer,
where
tumor
cells
microenvironment
(TME)
(e.g.,
tumor-associated
fibroblasts,
myeloid-derived
suppressor
cells)
secrete
to
evade
surveillance
promote
cancer
growth.
Within
TME,
enhances
differentiation
tolerogenic
dendritic
cells,
induces
effector
proliferation
regulatory
collectively
facilitating
escape.
Therefore,
targeting
holds
potential
boost
anti-tumor
immunity
improve
efficacy
immunotherapy.
This
review
provides
insights
into
intricate
regulation,
with
an
emphasis
on
elucidates
how
tumors
exploit
for
evasion
Furthermore,
we
discuss
as
therapeutic
target
augment
current
immunotherapies
across
various
types.
Language: Английский
Clinical Periodontal Evaluation and Assessment of Dipeptidyl-Peptidase-4 and Galectin-3 in Gingival Crevicular Fluid of Periodontitis Patients with Heart Failure and Diabetes
Journal of Clinical Medicine,
Journal Year:
2025,
Volume and Issue:
14(10), P. 3345 - 3345
Published: May 12, 2025
Background/Objectives:
Periodontitis,
a
prevalent
chronic
inflammatory
disease
affecting
tooth-supporting
structures,
has
been
increasingly
linked
to
systemic
conditions
such
as
diabetes
mellitus
(DM)
and
cardiovascular
diseases
(CVDs).
This
study
aimed
evaluate
the
periodontal
status
levels
of
dipeptidyl
peptidase-4
(DPP-4)
galectin-3
(Gal-3)
in
gingival
crevicular
fluid
(GCF)
patients
with
periodontitis,
heart
failure
(HF),
diabetes,
exploring
their
potential
biomarkers
for
association.
Methods:
A
cross-sectional
was
conducted
on
88
categorized
into
four
groups:
periodontally
systemically
healthy
(control,
C);
periodontitis
(P);
HF
(P+HF);
HF,
(P+HF+D).
Periodontal
assessed
using
probing
pocket
depth
(PPD)
Gingival
Index
(GI).
GCF
samples
were
collected
analyzed
DPP-4
Gal-3
ELISA.
Statistical
analyses
performed
assess
differences
between
groups
correlations.
Results:
Results
indicated
significantly
higher
all
test
compared
controls
(p
<
0.0001),
highest
P+HF+D
group.
Similarly,
elevated
patients,
particularly
those
there
no
significant
difference
P+HF
groups.
No
observed
smokers
non-smokers
regarding
these
markers.
Positive
correlations
found
parameters
immunological
markers
Conclusions:
The
findings
suggest
that
may
serve
association
being
more
upregulated
failure.
Language: Английский