Clinical Periodontal Evaluation and Assessment of Dipeptidyl-Peptidase-4 and Galectin-3 in Gingival Crevicular Fluid of Periodontitis Patients with Heart Failure and Diabetes DOI Open Access

Ana Păvălan,

Mihail Virgil Boldeanu, Flavia Mirela Nicolae

et al.

Journal of Clinical Medicine, Journal Year: 2025, Volume and Issue: 14(10), P. 3345 - 3345

Published: May 12, 2025

Background/Objectives: Periodontitis, a prevalent chronic inflammatory disease affecting tooth-supporting structures, has been increasingly linked to systemic conditions such as diabetes mellitus (DM) and cardiovascular diseases (CVDs). This study aimed evaluate the periodontal status levels of dipeptidyl peptidase-4 (DPP-4) galectin-3 (Gal-3) in gingival crevicular fluid (GCF) patients with periodontitis, heart failure (HF), diabetes, exploring their potential biomarkers for association. Methods: A cross-sectional was conducted on 88 categorized into four groups: periodontally systemically healthy (control, C); periodontitis (P); HF (P+HF); HF, (P+HF+D). Periodontal assessed using probing pocket depth (PPD) Gingival Index (GI). GCF samples were collected analyzed DPP-4 Gal-3 ELISA. Statistical analyses performed assess differences between groups correlations. Results: Results indicated significantly higher all test compared controls (p < 0.0001), highest P+HF+D group. Similarly, elevated patients, particularly those there no significant difference P+HF groups. No observed smokers non-smokers regarding these markers. Positive correlations found parameters immunological markers Conclusions: The findings suggest that may serve association being more upregulated failure.

Language: Английский

Galectins and Liver Diseases DOI Open Access
Shima Mimura, Asahiro Morishita, Kyoko Oura

et al.

International Journal of Molecular Sciences, Journal Year: 2025, Volume and Issue: 26(2), P. 790 - 790

Published: Jan. 18, 2025

Galectins are widely distributed throughout the animal kingdom, from marine sponges to mammals. a family of soluble lectins that specifically recognize β-galactoside-containing glycans and categorized into three subgroups based on number function their carbohydrate recognition domains (CRDs). The interaction galectins with specific ligands mediates wide range biological activities, depending cell type, tissue context, expression levels individual galectin, receptor involvement. affect various immune processes through both intracellular extracellular mechanisms play roles in processes, such as apoptosis, angiogenesis, fibrosis. Their importance has increased recent years because they recognized biomarkers, therapeutic agents, drug targets, many other applications conditions cardiovascular diseases cancer. However, little is known about involvement liver diseases. Here, we review functions evaluate

Language: Английский

Citations

1

The sweet and the bitter sides of galectin-1 in immunity: its role in immune cell functions, apoptosis, and immunotherapies for cancer with a focus on T cells DOI Creative Commons
Julianna Novák, T. Takács, Álmos Tilajka

et al.

Seminars in Immunopathology, Journal Year: 2025, Volume and Issue: 47(1)

Published: April 3, 2025

Galectin-1 (Gal-1), a member of the β-galactoside-binding soluble lectin family, is double-edged sword in immunity. On one hand, it plays crucial role regulating diverse immune cell functions, including apoptosis activated T cells. These processes are key resolving inflammation and preventing autoimmune diseases. other Gal-1 has significant implications cancer, where tumor cells microenvironment (TME) (e.g., tumor-associated fibroblasts, myeloid-derived suppressor cells) secrete to evade surveillance promote cancer growth. Within TME, enhances differentiation tolerogenic dendritic cells, induces effector proliferation regulatory collectively facilitating escape. Therefore, targeting holds potential boost anti-tumor immunity improve efficacy immunotherapy. This review provides insights into intricate regulation, with an emphasis on elucidates how tumors exploit for evasion Furthermore, we discuss as therapeutic target augment current immunotherapies across various types.

Language: Английский

Citations

0

Clinical Periodontal Evaluation and Assessment of Dipeptidyl-Peptidase-4 and Galectin-3 in Gingival Crevicular Fluid of Periodontitis Patients with Heart Failure and Diabetes DOI Open Access

Ana Păvălan,

Mihail Virgil Boldeanu, Flavia Mirela Nicolae

et al.

Journal of Clinical Medicine, Journal Year: 2025, Volume and Issue: 14(10), P. 3345 - 3345

Published: May 12, 2025

Background/Objectives: Periodontitis, a prevalent chronic inflammatory disease affecting tooth-supporting structures, has been increasingly linked to systemic conditions such as diabetes mellitus (DM) and cardiovascular diseases (CVDs). This study aimed evaluate the periodontal status levels of dipeptidyl peptidase-4 (DPP-4) galectin-3 (Gal-3) in gingival crevicular fluid (GCF) patients with periodontitis, heart failure (HF), diabetes, exploring their potential biomarkers for association. Methods: A cross-sectional was conducted on 88 categorized into four groups: periodontally systemically healthy (control, C); periodontitis (P); HF (P+HF); HF, (P+HF+D). Periodontal assessed using probing pocket depth (PPD) Gingival Index (GI). GCF samples were collected analyzed DPP-4 Gal-3 ELISA. Statistical analyses performed assess differences between groups correlations. Results: Results indicated significantly higher all test compared controls (p < 0.0001), highest P+HF+D group. Similarly, elevated patients, particularly those there no significant difference P+HF groups. No observed smokers non-smokers regarding these markers. Positive correlations found parameters immunological markers Conclusions: The findings suggest that may serve association being more upregulated failure.

Language: Английский

Citations

0