The Impact of Oral Microbiome Dysbiosis on the Aetiology, Pathogenesis, and Development of Oral Cancer

Cancers, Journal Year: 2024, Volume and Issue: 16(17), P. 2997 - 2997

Published: Aug. 28, 2024

Oral squamous cell carcinoma (OSCC) is the most common head and neck cancer. Although oral cavity an easily accessible area for visual examination, OSCC more often detected at advanced stage. The global prevalence of around 6%, with increasing trends posing a significant health problem due to increase in morbidity mortality. microbiome has been target numerous studies, findings highlighting role dysbiosis developing OSCC. Dysbiosis can significantly pathobionts (bacteria, viruses, fungi, parasites) that trigger inflammation through their virulence pathogenicity factors. In contrast, chronic bacterial contributes development Pathobionts also have other effects, such as impact on immune system, which alter responses contribute pro-inflammatory environment. Poor hygiene carbohydrate-rich foods risk factors mechanisms are not yet fully understood remain frequent research topic. For this reason, narrative review concentrates issue potential cause OSCC, well underlying involved.

Language: Английский

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Current Evidence on the Relation Between Microbiota and Oral Cancer—The Role of Fusobacterium nucleatum—A Narrative Review

Cancers, Journal Year: 2025, Volume and Issue: 17(2), P. 171 - 171

Published: Jan. 7, 2025

Oral squamous cell carcinoma (OSCC) is one the most prevalent head and neck cancers represents a major cause of morbidity mortality worldwide. The main established risk factors for OSCC include tobacco alcohol consumption betel quid chewing, which may contribute alone or in combination with other environmental to carcinogenesis. oral microbiota emerging as key player establishment molecular cellular mechanisms that trigger promote carcinogenesis, including cavity. Among bacterial species found microbiota, Fusobacterium nucleatum, an anaerobic bacterium commonly biofilms periodontal pathogen, has gained attention due solid evidence implicating F. nucleatum colorectal cancer (CRC). been shown induce chronic inflammation, proliferation invasion while deploying immune evasion mechanisms. These experimental findings were first obtained vitro vivo models CRC are being confirmed studies on OSCC. In this review, we summarize recent role OSCC, discuss clinical implications terms prognosis provide overview involved. Moreover, identify research questions aspects require investigations clarify We anticipate field have significant impact diagnosis, management

Language: Английский

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Linking microbiome to cancer: A mini-review on contemporary advances

The Microbe, Journal Year: 2025, Volume and Issue: unknown, P. 100279 - 100279

Published: Feb. 1, 2025

Language: Английский

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Microbial Signatures in Oral Submucous Fibrosis and Oral Squamous Cell Carcinoma: Implications of Tobacco and Betel Quid Consumption

Journal of Oral Biosciences, Journal Year: 2025, Volume and Issue: unknown, P. 100656 - 100656

Published: March 1, 2025

Language: Английский

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Oral Fusobacterium nucleatum exacerbates ulcerative colitis via the oral-gut axis: mechanisms and therapeutic implications

Frontiers in Cellular and Infection Microbiology, Journal Year: 2025, Volume and Issue: 15

Published: April 7, 2025

Fusobacterium nucleatum (F. nucleatum) is an anaerobic bacterium known for its association with periodontal disease and oral infections. It has been implicated in the development of gastrointestinal diseases such as inflammatory bowel colorectal cancer. Ulcerative colitis (UC), which characterized by chronic inflammation colon, a condition unknown etiology rising incidence rate, significantly affecting quality life patients. The increased intestinal permeability during UC may facilitate adherence or invasion F. into damaged barrier, leading to exacerbated inflammation. This article introduces concept oral-gut axis, reviewing existing literature analyze role pathogenesis exploring potential pathogenic mechanisms. also summarizes latest advances treating patients who have looks forward prospective therapeutic strategies translational prospects within axis. be key player UC, likely due invasiveness periods permeability. paper discusses innovative approaches prevention management nucleatum, paving way more effective treatment UC. review offers new insights complex relationship between microbiome diseases, enhancing our understanding their dynamic interactions. There paucity on approaches, indicating need further clinical research.

Language: Английский

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Altered Bacteria Abundance Is Associated With Outcomes in Head and Neck Squamous Cell Carcinoma

Otolaryngology, Journal Year: 2025, Volume and Issue: unknown

Published: April 14, 2025

Abstract Objective To determine if microbiome differences exist in head and neck squamous cell carcinoma (HNSCC) based on high‐risk pathologic features, smoking, outcomes using The Cancer Microbiome Atlas (TCMA). Study Design Database study. Setting review. Methods TCMA is a publicly available database containing curated, decontaminated microbial profiles for tumors from 1772 patients. data were limited to profiles, survival, clinicopathologic features HNSCC Phyloseq objects created, low‐read samples removed, differential abundance analysis (DAA) Analysis of Compositions Microbiomes with Bias Correction 2 (ANCOM‐BC2) was performed. Statistical done R (v4.3.1). Results One hundred fifty‐six patients included mean age 59 (std 13, min 19, max 90), 72% male (n = 113), 91% white 140). Primary sites encompassed oral cavity 106, 68%), oropharynx 26, 17%), larynx/hypopharynx 24, 15%). For all TCMA, rates lymphovascular invasion 17% 26), perineural invasion, 34% 53), microscopic or gross extranodal extension (ENE), 19% 30). DAA revealed significant changes bacterial genera smoking status, vital disease‐specific survival (DSS). Genera observed ANCOM‐BC2 include Scardovia , Alloscardovia Lactobacillus Corynebacterium status DSS. Conclusion Changes the relative select intratumoral are associated adverse DSS, HNSCC. Shifts need further investigation they can provide any mechanistic insight predictive role.

Language: Английский

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Effect of the oral microbiota, blood metabolome, and inflammatory proteins on oral cavity cancer: a bidirectional two-sample Mendelian randomization study and mediation analysis

Journal of Stomatology Oral and Maxillofacial Surgery, Journal Year: 2025, Volume and Issue: unknown, P. 102372 - 102372

Published: April 1, 2025

Language: Английский

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Head and neck cancer trends in Ohio: Examining temporal, anatomical, and geospatial patterns across Appalachian and non-Appalachian regions

American Journal of Otolaryngology, Journal Year: 2025, Volume and Issue: unknown, P. 104634 - 104634

Published: April 1, 2025

Head and neck cancer (HNC) is the seventh most common type of worldwide. Compared to rest United States, Appalachia has higher incidence rates HNC. The purpose this project examine temporal, anatomical, geospatial variances in head cancers across Ohio, focusing on disparities between Appalachian non-Appalachian regions. Data was sourced from Center for Disease Control Prevention Surveillance, Epidemiology, End Results database. mortality HNC Ohio were identified sub classified based anatomical site. Social determinants health environmental factors affecting raters compared (R = 0.9, P < 0.01) 0.8, increased significantly 1999 2021 demonstrated a relationship with 0.3, 0.01). Adult smoking 0.5, 0.001), obesity dentist associated rates. Mean (mean 10.7, SD 2.6) than 8.6, 2.4) regions (P communities. These findings emphasize importance addressing modifiable risk through cessation, weight management, dietary improvements. difference underscores role geographic socioeconomic shaping outcomes Ohio.

Language: Английский

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DIFFERENCES IN ORAL MICROBIOTA BETWEEN ELDERLY AND ADULTS: A SYSTEMATIC REVIEW

Archives of Oral Biology, Journal Year: 2025, Volume and Issue: unknown, P. 106278 - 106278

Published: May 1, 2025

Language: Английский

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Is Short-Read 16S rRNA Sequencing of Oral Microbiome Sampling a Suitable Diagnostic Tool for Head and Neck Cancer?

Published: Aug. 27, 2024

The oral microbiome, studied by sampling the saliva or rinse, has been long thought to have diagnostic capacity for head and neck cancers (HNC). However, previous reports on HNC microbiome provide inconsistent results. aim of this study is consolidate these datasets determine microbial composition between patients healthy premalignant individuals. We analyzed 16 published cancer (HNC) short-read 16S rRNA sequencing datasets, specifically targeting V3V4, V4 V4V5 regions. These included rinse samples from donors with HNC, as well donors. Differences in diversities abundance were determined. displayed lower alpha diversity than In contrast, opposite trend was observed samples. Beta largely similar across different patient types. Similar phyla detected all samples, but proportions dependent sample type (i.e. rinse) primer set utilised sequencing. Neisseria, Leptotrichia Megasphaera elevated saliva, while Mycoplasma saliva. Oral enrichment Fusobacterium, Veillonella, Alloprevotella, Campylobacter had conflicting sparse partial least squares discriminant analysis model performed effectively discriminating using V3V4 (AUC = 0.888), 0.928), poor discriminative 0.688). conclusion, our meta-analysis highlighted limitations sequencing, particularly due variations batches, sets V4), Hence, caution should be exercised when interpreting results studies, especially types are used.

Language: Английский

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