International Journal of Histopathological Interpretation,
Journal Year:
2024,
Volume and Issue:
13(1), P. 22 - 27
Published: June 26, 2024
Oral
squamous
cell
carcinoma
(OSCC)
presents
a
significant
global
health
challenge,
with
established
risk
factors
including
tobacco
use,
alcohol
consumption,
and
human
papillomavirus
(HPV)
infection.
Recent
research
has
illuminated
the
role
of
oral
microbiome
in
OSCC
pathogenesis,
highlighting
microbial
dysbiosis—a
disruption
balance—as
potential
contributor
to
disease
development.
This
review
examines
how
dysbiosis
influences
through
altered
composition,
chronic
inflammation,
production
carcinogenic
metabolites,
biofilm
formation.
Pathogenic
bacteria
like
Fusobacterium
nucleatum
Porphyromonas
gingivalis
are
implicated
fostering
pro-inflammatory
milieu
conducive
carcinogenesis.
Additionally,
metabolites
biofilms
play
crucial
roles
progression.
The
underscores
promise
biomarkers
interventions
such
as
probiotics,
prebiotics,
targeted
antimicrobial
therapies
early
detection
therapeutic
strategies
for
OSCC.
Future
directions
should
focus
on
optimizing
these
approaches
improve
clinical
outcomes
while
minimizing
unintended
consequences
associated
modulation.
Pathogens,
Journal Year:
2024,
Volume and Issue:
13(10), P. 826 - 826
Published: Sept. 24, 2024
The
oral
microbiome,
studied
by
sampling
the
saliva
or
rinse,
has
been
long
thought
to
have
diagnostic
capacity
for
head
and
neck
cancers
(HNC).
However,
previous
reports
on
HNC
microbiome
provide
inconsistent
results.
aim
of
this
study
is
consolidate
these
datasets
determine
microbial
composition
between
patients
healthy
premalignant
individuals.
We
analyzed
16
published
cancer
(HNC)
short-read
16S
rRNA
sequencing
datasets,
specifically
targeting
V3V4,
V4
V4V5
regions.
These
included
rinse
samples
from
donors
with
HNC,
as
well
donors.
Differences
in
diversities
abundance
were
determined.
displayed
lower
alpha
diversity
than
In
contrast,
opposite
trend
was
observed
samples.
Beta
scores
largely
similar
across
different
patient
types.
Similar
phyla
detected
all
samples,
but
proportions
dependent
sample
type
(i.e.,
rinse)
primer
set
utilized
sequencing.
Pathologica,
Journal Year:
2024,
Volume and Issue:
116(6), P. 338 - 357
Published: Dec. 1, 2024
Oral
squamous
cell
carcinoma
(OSCC)
is
one
of
the
most
common
cancers
worldwide.
Despite
advances
in
diagnosis
and
treatment,
incidence
OSCC
increasing,
mortality
rate
remains
high.
This
systematic
review
aims
to
examine
potential
association
between
composition
oral
microbiota
OSCC.
International Journal of Histopathological Interpretation,
Journal Year:
2024,
Volume and Issue:
13(1), P. 22 - 27
Published: June 26, 2024
Oral
squamous
cell
carcinoma
(OSCC)
presents
a
significant
global
health
challenge,
with
established
risk
factors
including
tobacco
use,
alcohol
consumption,
and
human
papillomavirus
(HPV)
infection.
Recent
research
has
illuminated
the
role
of
oral
microbiome
in
OSCC
pathogenesis,
highlighting
microbial
dysbiosis—a
disruption
balance—as
potential
contributor
to
disease
development.
This
review
examines
how
dysbiosis
influences
through
altered
composition,
chronic
inflammation,
production
carcinogenic
metabolites,
biofilm
formation.
Pathogenic
bacteria
like
Fusobacterium
nucleatum
Porphyromonas
gingivalis
are
implicated
fostering
pro-inflammatory
milieu
conducive
carcinogenesis.
Additionally,
metabolites
biofilms
play
crucial
roles
progression.
The
underscores
promise
biomarkers
interventions
such
as
probiotics,
prebiotics,
targeted
antimicrobial
therapies
early
detection
therapeutic
strategies
for
OSCC.
Future
directions
should
focus
on
optimizing
these
approaches
improve
clinical
outcomes
while
minimizing
unintended
consequences
associated
modulation.
