Neurobehavioral disorders among children born to mothers exposed to illicit substances during pregnancy DOI Creative Commons

Vincent Chin-Hung Chen,

Charles Tzu‐Chi Lee, Shu‐I Wu

et al.

BMC Medicine, Journal Year: 2024, Volume and Issue: 22(1)

Published: Dec. 18, 2024

Exposure to illicit substances during pregnancy may have long-term impacts on children's neurodevelopment. This study explores subsequent risks for intellectual disability, autistic disorders, and attention deficit hyperactivity disorders in children born mothers exposed before or pregnancy. We identified women with drug use by linking the police records from "Substance Abuse Control Databases" Taiwan Birth Registration Notification 2004 2014. Children whose that had were "substance-exposed cohort." A 1:1 ratio exact-matched comparison cohort based child's gender, birth year, mother's first of health insurance card, as well a "propensity score (PS)-matched" substance-unexposed mothers, was established. Multivariate Cox regression analyses competing risk models performed. Higher incidences disability (adjusted hazard (aHR) = 2.41, 95% confidence interval (CI): 1.15–5.03) disorder (ADHD) (aHR 2.35, CI: 1.63–3.28) found prenatally compared non-exposed cohorts. Adjusted ADHD significantly higher 1.77 (1.42–2.21)) 1.43 (1.14–1.80)) PS-matched unexposed cohorts after adjusting covariates. is one studies using large population-based data linked criminal reveal increased prenatal exposure matched controls. Our results also highlight importance preventive measures interventions well-being both mother child.

Language: Английский

Congenital hypothyroidism and associated visual-motor and intellectual development DOI Creative Commons
Esperanza Ontiveros-Mendoza,

Juan Antonio González-Medrano,

Rolando Rivera–González

et al.

Pediatric Research, Journal Year: 2025, Volume and Issue: unknown

Published: Jan. 22, 2025

Abstract Background Congenital hypothyroidism’s sequelae include visuomotor and intellectual developmental deficits. Visual-motor perception is a cognitive function related to academic performance. Intellect the ability learn use acquired knowledge solve achieve goals. Our objective was evaluate visual-motor development in children with late initiation of treatment for congenital hypothyroidism enrolled follow-up intervention program. Methods We evaluated 75 infants hypothyroidism, 34 athyrosis, 41 ectopia using Bender Visual-Motor Development Test Weschler Intelligence Scale at eight nine years age. Results Children had delay −2 an Quotient (IQ) greater than 98 points. athyrosis equivalent −3.2 IQ below 90 Better performance on Bender’s test positively correlated IQ. Attending more 80% Developmental Intervention Program appointments positive impact development. Conclusions Timely diagnosis early appropriate dose levothyroxine are determining factors; however, attendance program could further support hypothyroidism. Impact Visuomotor influences functions school Deficits problems goals characteristic Delayed associated severe both Here, we show that adequate doses inclusion highly recommended patients delayed treatment. A better understanding these factors will allow clinicians target therapeutic interventions.

Language: Английский

Citations

0
Effect of home environment on neuropsychiatric development in preterm infants discharged from NICU at 18 months corrected age DOI Creative Commons
Yuan Tian, Chuncao Zhang, Feng Liu

et al.

General Psychiatry, Journal Year: 2025, Volume and Issue: 38(1), P. e101634 - e101634

Published: Jan. 1, 2025

Background There have been numerous intervention studies focusing on the development of preterm infants, but there has limited investigation into home environment as a determinant developmental outcomes in infants. The aspects and extent to which affects early (18 months corrected age) neuropsychological infants are still unclear. Aims This study aimed analyse effect neuropsychiatric at 18 age after discharge from neonatal intensive care unit (NICU). It also sought provide basis for promoting among by improving environment. Methods In this retrospective cross-sectional study, 275 born between January 2019 2022 were followed up systematic management NICU Shanghai Children’s Hospital. Home Nurture Environment Questionnaire was used assess its impact quotient (evaluated Gesell Developmental Scale) rate delays age. Results A total 41.454% extremely preterm. scores middle scale. language domain had highest delay (46.182%), adaptive (37.091%). Multiple logistic regression analyses showed that compared with supportive environments, moderate/unsupportive environments significantly elevated risks delay: 2.162-fold global (odds ratio (OR) 2.162, 95% confidence interval (CI) 1.274 3.665, p=0.004), 2.193-fold fine motor (OR 2.193, CI 1.161 4.140, p=0.016), 2.249-fold 2.249, 1.336 3.786, p=0.002) 2.042-fold personal-social 2.042, 1.149 3.628, p=0.015). Conclusions is crucial protective factor associated higher protects against delays. Incorporating evaluation continuous improvement framework promote optimal neurodevelopment essential.

Language: Английский

Citations

0
In-hospital motor interventions to reduce neurodevelopmental impairment in preterm infants: a scoping review DOI
Anna Badura, Michelle Fiander, Anna Gabriel

et al.

Cochrane library, Journal Year: 2025, Volume and Issue: 2025(4)

Published: April 3, 2025

Language: Английский

Citations

0
The shifting landscape of the preterm brain DOI
Panagiotis Kratimenos, Georgios Sanidas, Gabriele Simonti

et al.

Neuron, Journal Year: 2025, Volume and Issue: unknown

Published: April 1, 2025

Language: Английский

Citations

0
Aggressive and Autoaggressive Behaviors in Patients with Autism Spectrum Disorder in Correlation with Middle Cerebral Artery Flow Velocity DOI Open Access

Maciej Abakumow,

Maciej Przybylski,

Mariusz Słoma

et al.

Journal of Personalized Medicine, Journal Year: 2024, Volume and Issue: 14(9), P. 1010 - 1010

Published: Sept. 22, 2024

Background/Objectives The purpose of this study was to see whether there is a correlation between the behavior autism spectrum disorder patients and brain abnormalities based on velocity blood flow in MCA (

Language: Английский

Citations

0
Neurobehavioral disorders among children born to mothers exposed to illicit substances during pregnancy DOI Creative Commons

Vincent Chin-Hung Chen,

Charles Tzu‐Chi Lee, Shu‐I Wu

et al.

BMC Medicine, Journal Year: 2024, Volume and Issue: 22(1)

Published: Dec. 18, 2024

Exposure to illicit substances during pregnancy may have long-term impacts on children's neurodevelopment. This study explores subsequent risks for intellectual disability, autistic disorders, and attention deficit hyperactivity disorders in children born mothers exposed before or pregnancy. We identified women with drug use by linking the police records from "Substance Abuse Control Databases" Taiwan Birth Registration Notification 2004 2014. Children whose that had were "substance-exposed cohort." A 1:1 ratio exact-matched comparison cohort based child's gender, birth year, mother's first of health insurance card, as well a "propensity score (PS)-matched" substance-unexposed mothers, was established. Multivariate Cox regression analyses competing risk models performed. Higher incidences disability (adjusted hazard (aHR) = 2.41, 95% confidence interval (CI): 1.15–5.03) disorder (ADHD) (aHR 2.35, CI: 1.63–3.28) found prenatally compared non-exposed cohorts. Adjusted ADHD significantly higher 1.77 (1.42–2.21)) 1.43 (1.14–1.80)) PS-matched unexposed cohorts after adjusting covariates. is one studies using large population-based data linked criminal reveal increased prenatal exposure matched controls. Our results also highlight importance preventive measures interventions well-being both mother child.

Language: Английский

Citations

0