Silibinin as potential tool against SARS‐Cov‐2: In silico spike receptor‐binding domain and main protease molecular docking analysis, and in vitro endothelial protective effects DOI Creative Commons
Antonio Speciale, Claudia Muscarà, Maria Sofia Molonia

et al.

Phytotherapy Research, Journal Year: 2021, Volume and Issue: 35(8), P. 4616 - 4625

Published: April 6, 2021

The spread of SARS‐CoV‐2, along with the lack targeted medicaments, encouraged research existing drugs for repurposing. rapid response to SARS‐CoV‐2 infection comprises a complex interaction cytokine storm, endothelial dysfunction, inflammation, and pathologic coagulation. Thus, active molecules targeting multiple steps in lifecycle are highly wanted. Herein we explored silico capability silibinin from Silybum marianum interact main target proteins, vitro effects against cytokine‐induced‐inflammation dysfunction human umbilical vein cells (HUVECs). Computational analysis revealed that forms stable spike protein RBD, has good negative binding affinity Mpro, interacts many residues on site thus supporting its potentiality inhibiting viral entry replication. Moreover, HUVECs pretreatment reduced TNF‐α‐induced gene expression proinflammatory genes IL‐6 MCP‐1, as well PAI‐1, critical factor coagulopathy thrombosis, ET‐1, peptide involved hemostatic vasoconstriction. Then, due endothelium antiinflammatory anticoagulant properties proteins demonstrated herein, could be strong candidate COVID‐19 management multitarget perspective.

Language: Английский

Comorbidities in rheumatic diseases need special consideration during the COVID-19 pandemic DOI Creative Commons
Sakir Ahmed, Armen Yuri Gasparyan, Olena Zimba

et al.

Rheumatology International, Journal Year: 2021, Volume and Issue: 41(2), P. 243 - 256

Published: Jan. 3, 2021

Language: Английский

Citations

68
Endothelial Dysfunction in the Brain DOI Open Access
Maithili Sashindranath, Harshal Nandurkar

Stroke, Journal Year: 2021, Volume and Issue: 52(5), P. 1895 - 1904

Published: April 2, 2021

The Coronavirus disease 2019 (COVID)-19 pandemic has already affected millions worldwide, with a current mortality rate of 2.2%. While it is well-established that severe acute respiratory syndrome-coronavirus-2 causes upper and lower tract infections, number neurological sequelae have now been reported in large proportion cases. Additionally, the arterial venous thromboses including pulmonary embolism, myocardial infarction, significant cerebrovascular complications. increasing incidence vessel ischemic strokes as well intracranial hemorrhages, frequently younger individuals, associated increased morbidity mortality, raised questions to why brain major target disease. COVID-19 characterized by hypercoagulability alterations hemostatic markers high D-dimer levels, which are prognosticator poor outcome. Together findings fibrin-rich microthrombi, widespread extracellular fibrin deposition various organs hypercytokinemia, this suggests more than viral infection. Evidently, thrombo-inflammatory Endothelial cells constitute lining blood vessels primary targets response, syndrome coronavirus 2 also directly infects endothelial through ACE2 (angiotensin-converting enzyme 2) receptor. Being highly heterogeneous their structure function, differences may govern susceptibility COVID-19. Here, we explored how unique characteristics cerebral endothelium be underlying reason for rates pathology

Language: Английский

Citations

68
COVID-19 Pathophysiology Predicts That Ischemic Stroke Occurrence Is an Expectation, Not an Exception—A Systematic Review DOI Creative Commons
Tissa Wijeratne, Sheila G. Crewther, Carmela Sales

et al.

Frontiers in Neurology, Journal Year: 2021, Volume and Issue: 11

Published: Jan. 28, 2021

Clinical reports of neurological manifestations associated with severe coronavirus disease 2019 (COVID-19), such as acute ischemic stroke (AIS), encephalopathy, seizures, headaches, necrotizing encephalitis, cerebral microbleeds, posterior reversible leukoencephalopathy syndrome, hemophagocytic lymphohistiocytosis, peripheral neuropathy, cranial nerve palsies, transverse myelitis, and demyelinating disorders, are increasing rapidly. However, there comparatively few studies investigating the potential impact immunological responses secondary to hypoxia, oxidative stress, excessive platelet-induced aggregation on brain. This scoping review has focused pathophysiological mechanisms consequential neural (central) inflammation leading COVID-19-related strokes. It also highlights common biological processes shared between AIS COVID-19 infection importance recognition that respiratory dysfunction impairments COVID chronic [post-COVID-19 syndrome (PCNS)] may significantly recovery ability benefit from neurorehabilitation. study provides a comprehensive pathobiology stroke. affirms contribution pathophysiology is predictive sequelae particularly stroke, which makes it expectation rather than exception. work fundamental significance neurorehabilitation community given number COVID-related strokes, current limited knowledge regarding risk reinfection, recent PCNS. further need for global collaboration research into new pathobiology-based treatment strategies more integrated evidence-based care.

Language: Английский

Citations

66
The second decade of anti-TNF-a therapy in clinical practice: new lessons and future directions in the COVID-19 era DOI Open Access
Gerasimos Evangelatos, Giorgos Bamias, George D. Kitas

et al.

Rheumatology International, Journal Year: 2022, Volume and Issue: 42(9), P. 1493 - 1511

Published: May 3, 2022

Language: Английский

Citations

62
COVID-19 and thrombosis: The role of hemodynamics DOI Open Access

Sudeep Sastry,

Federica Cuomo, Jayaveera Muthusamy

et al.

Thrombosis Research, Journal Year: 2022, Volume and Issue: 212, P. 51 - 57

Published: Feb. 23, 2022

Language: Английский

Citations

54
Understanding Long COVID; Mitochondrial Health and Adaptation—Old Pathways, New Problems DOI Creative Commons
Alistair V.W. Nunn,

Geoffrey W. Guy,

Wolfgang Brysch

et al.

Biomedicines, Journal Year: 2022, Volume and Issue: 10(12), P. 3113 - 3113

Published: Dec. 2, 2022

Many people infected with the SARS-CoV-2 suffer long-term symptoms, such as "brain fog", fatigue and clotting problems. Explanations for "long COVID" include immune imbalance, incomplete viral clearance potentially, mitochondrial dysfunction. As conditions sub-optimal function are associated initial severity of disease, their prior health could be key in resistance to long COVID recovery. The SARs virus redirects host metabolism towards replication; response, can metabolically react control virus. Resolution is normally achieved after stress activates a hormetic negative feedback mechanism. It therefore possible that, some individuals function, "tip" into chronic inflammatory cycle. This might explain main including platelet Long thus described virally induced self-perpetuating imbalanced non-resolving state characterised by dysfunction, where reactive oxygen species continually drive inflammation shift glycolysis. would suggest that sufferer's needs "tipped" back using stimulus, physical activity, calorie restriction, or chemical compounds mimic these enhancing perhaps combination inhibitors quell response.

Language: Английский

Citations

54
Multisystem Inflammatory Syndrome and Autoimmune Diseases Following COVID-19: Molecular Mechanisms and Therapeutic Opportunities DOI Creative Commons
Parastoo Hosseini, Mohammad Sadegh Fallahi, Gisou Erabi

et al.

Frontiers in Molecular Biosciences, Journal Year: 2022, Volume and Issue: 9

Published: April 14, 2022

Coronavirus disease 2019 (COVID-19), caused by severe acute respiratory syndrome-coronavirus 2 (SARS-CoV-2), has led to huge concern worldwide. Some SARS-CoV-2 infected patients may experience post–COVID-19 complications such as multisystem inflammatory syndrome, defined symptoms including fever and elevated markers (such elevation of C reactive protein (CRP), erythrocyte sedimentation rate, fibrinogen, procalcitonin test, D-dimer, ferritin, lactate dehydrogenase or IL-6, presence neutrophilia, lymphopenia, decreased albumin, multiple organ dysfunction). Post–COVID-19 also manifest autoimmune diseases Guillain-Barré syndrome systemic lupus erythematosus. Signaling disorders, increased cytokines secretion, corticosteroid use treat COVID-19 patients, impaired immune responses are suggested causes in these patients. In this review, we discuss the molecular pathophysiological mechanisms therapeutic opportunities for following infection with aim provide a clear view health care providers researchers.

Language: Английский

Citations

39
Long COVID Syndrome and Cardiovascular Manifestations: A Systematic Review and Meta-Analysis DOI Creative Commons
Abhigan Babu Shrestha, Aashna Mehta, Pashupati Pokharel

et al.

Diagnostics, Journal Year: 2023, Volume and Issue: 13(3), P. 491 - 491

Published: Jan. 29, 2023

(1) Background: Long COVID syndrome is a significant cause of morbidity in COVID-19 patients who remain symptomatic with varied clinical presentations beyond three weeks. Furthermore, the relevance considering cardiovascular outcomes post-COVID-19 important current pandemic; (2) Methods: The Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) guidelines were followed this systematic review meta-analysis. searches conducted from multiple databases without language restrictions until October 8, 2022, to find studies evaluating such as arrhythmias, myocardium pericardium diseases, coronary vessel disease, thromboembolic disorders post-COVID cases. pooled odds ratio (OR), standard mean difference (SMD) their corresponding 95% confidence intervals (CI) computed association; (3) Results: Altogether, seven total 8,126,462 (cases: 1,321,305; controls: 6,805,157) participants included Pooled ratios significantly higher cases (OR > 1, p < 0.05) than controls. However, mortality (OR: 4.76, = 0.13), heart rate variability (SMD: −0.06, 0.91) between controls not statistically significant; (4) Conclusions: Significant sequelae long highlight importance careful cardiac monitoring phase address complications soon possible; larger-scale prospective are required accurate estimation.

Language: Английский

Citations

30
When Does the Cytokine Storm Begin in COVID-19 Patients? A Quick Score to Recognize It DOI Open Access
Stefano Cappanera,

Michele Palumbo,

Sherman Kwan

et al.

Journal of Clinical Medicine, Journal Year: 2021, Volume and Issue: 10(2), P. 297 - 297

Published: Jan. 15, 2021

Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is the virus that responsible for disease 2019 (COVID-19), which has rapidly spread across world, becoming a pandemic. The “cytokine storm” (CS) in COVID-19 leads to worst stage of illness, and its timely control through immunomodulators, corticosteroids, cytokine antagonists may be key reducing mortality. After reviewing published studies, we proposed Cytokine Storm Score (CSs) identify patients who were this hyperinflammation state, at risk progression poorer outcomes. We retrospectively analyzed 31 admitted Infectious Disease Department “St. Maria” Hospital Terni with confirmed SARS-CoV-2 infections, “CS score” severity COVID-19. Then conducted prospective study after definition CSscore. This first proposes applies new score quickly are stage, treat them order reduce intubation. CSs can accurately early stages CS, conduct timely, safe, effect administration antagonists, prevent

Language: Английский

Citations

52
Benefits and adverse effects of hydroxychloroquine, methotrexate and colchicine: searching for repurposable drug candidates DOI Open Access
Durga Prasanna Misra, Armen Yuri Gasparyan, Olena Zimba

et al.

Rheumatology International, Journal Year: 2020, Volume and Issue: 40(11), P. 1741 - 1751

Published: Sept. 2, 2020

Language: Английский

Citations

51