The impact of uric acid on musculoskeletal diseases: clinical associations and underlying mechanisms

Frontiers in Endocrinology, Journal Year: 2025, Volume and Issue: 16

Published: Feb. 4, 2025

Serum urate (SU) levels are significantly elevated in conditions such as gout, type 2 diabetes (T2D), obesity, and other metabolic syndromes. Recently, due to the high prevalence of hyperuricemia (HUA), numerous clinical connections between SU musculoskeletal disorders like sarcopenia, osteoarthritis (OA), rheumatoid arthritis (RA), intervertebral disc degeneration (IDD), osteoporosis (OP) have been identified. This review discusses mechanisms linking disorders, well associations with T2D McArdle disease, heart failure, OA, IDD, OP exercise-induced acute kidney injury (EIAKI), offering valuable insights for improved prevention treatment strategies. Mechanisms include oxidative stress, MSU (monosodium urate) crystal deposition, inflammation, factors. In adults, both age should be considered preventing while gender may directly impact muscle mass children adolescents. HUA gout risk factors OA progression, although some reports suggest otherwise. A U-shaped relationship IDD has reported, particularly Chinese men, indicating lower or higher level IDD. Maintaining within a certain range help prevent fractures. Future research, including epidemiological studies new pathogenesis findings, will further clarify diseases SU.

Language: Английский

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Body composition and skeletal muscles status in patients with rheumatoid arthritis during treatment with biologic disease-modifying antirheumatic drugs

Modern Rheumatology Journal, Journal Year: 2025, Volume and Issue: 19(1), P. 29 - 34

Published: Feb. 13, 2025

Objective : to evaluate body composition and functional status of muscle tissue in women with rheumatoid arthritis (RA) relation background therapy. Material methods . The study included 138 patients (mean age 60.8±8.6 years) confirmed RA. Of these, 18 received tumor necrosis factor-α inhibitors, 30 rituximab, 19 abatacept 71 methotrexate (MTX) monotherapy. A clinical laboratory examination, evaluation using dual-energy X-ray densitometry tests assess strength physical performance were performed. Results discussion Muscle fat mass, bone mineral density did not differ depending on the At same time, gait speed ≤0.8 m/s was less frequent receiving biologic disease-modifying antirheumatic drugs (bDMARDs) compared MT monotherapy (p<0.001). Significant correlations found between bDMARD therapy as assessed by results a short battery (p=0.035) (p=0.003). Logistic regression analysis association state. Conclusion. No differences type associated better skeletal state Keywords: arthritis; composition; drugs; performance> < 0.001). Conclusion

Language: Английский

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The Characteristic of Muscle Function for Sarcopenia in Patients with Rheumatoid Arthritis: A Large-Scale Real-World Cross-Sectional Study

Medicina, Journal Year: 2025, Volume and Issue: 61(4), P. 551 - 551

Published: March 21, 2025

Background and Objectives: Sarcopenia is a notable comorbidity of rheumatoid arthritis (RA), affecting about one third patients. However, the characteristic muscle function its association with RA disease remains unknown. Materials Methods: This cross-sectional study collected clinical data from real-world Chinese cohort. was defined as both myopenia low (LMF). Myopenia appendicular skeletal mass index (ASMI) < 7.0 kg/m2 in men <5.7 women. LMF strength (LMS, hand grip 28 kg <18 women) or physical performance (LPP, 6 m gait speed 1.0 m/s). Results: Among 1125 patients recruited this study, 928 were eligible for analysis. The prevalence sarcopenia, myopenia, LMF, LMS, LPP all 36.5%, 46.1%, 69.0%, 57.8%, 37.1%, respectively. According to their trends age activity, there 111 (11.9%) young (age 50 years) remission (CDAI ≤ 2.8) subgroup, 199 (21.4%) active > 198 (21.3%) old ≥ 420 (45.2%) subgroup. Compared two subgroups, respectively, subgroup had significantly lower strength, higher worse activity function. After adjustment potential confounders, multivariate multinominal logistic regression analysis showed that positively associated sarcopenia (OR = 3.193, 95%CI: 1.477–6.899), 2.390, 1.207–4.731), LMS 3.520, 1.743–7.110). Conclusions: Worse rather than reduced performance, more common at age. It underscores critical need early identification intervention dysfunction improve quality life.

Language: Английский

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Critical roles of IL-6 signaling in myoblast differentiation of human adipose-derived mesenchymal stem cells

Inflammation and Regeneration, Journal Year: 2025, Volume and Issue: 45(1)

Published: April 10, 2025

Abstract Background Ectopic fat is also formed in muscles as well the liver, where adipose-derived mesenchymal stem cells (ADSCs) promote adipogenesis. On other hand, after muscle injury, satellite (SCs) contribute to repair through myodifferentiation. Human ADSCs are multipotent cells, but it remains unclear whether they involved myoblast differentiation. The aim find a novel myogenic cytokine and its signaling pathway that promotes differentiation of human ADSCs—a potential source new precursor cells—into myoblasts. Methods An array kit was used detect cytokines produced by ADSCs. After treating with DNA methyltransferase inhibitor 5-Aza-2’-deoxycytidine (5-aza-C) different JAK inhibitors, MyHC1, myodifferentiation marker, detected immunofluorescence staining reverse transcription‐quantitative polymerase chain reaction (RT-qPCR). expression status molecules determined Western blotting recruitment transcription factors MYOG promoter chromatin immunoprecipitation (ChIP). Results IL-6 at high concentrations culture supernatant stimulated 5-aza-C became strongly positive for MyHC1 on day 21 post-stimulation. When co-stimulated IL-6/sIL-6R, protein upregulated mRNA early 14 Co-stimulation IL-6/sIL-6R resulted phosphorylation STAT1 STAT3. addition JAK2 inhibitor, not JAK1/3 abolished positivity during myogenesis process STAT1, STAT3, promoter. Myoblast induced stimulation enhanced activation IL-6/JAK2/STAT1/MYOG pathway. Conclusions Therefore, sustained IL-6/JAK2/STAT1 may serve an important driver ADSC into myoblast, suggesting candidate ameliorating atrophy.

Language: Английский

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Sarcopenia in Rheumatic Diseases: A Hidden Issue of Concern

Diseases, Journal Year: 2025, Volume and Issue: 13(5), P. 134 - 134

Published: April 26, 2025

Sarcopenia is characterized by a loss of muscle mass and function, with significant implications for the physical performance affected people. Although commonly associated aging, disease-related sarcopenia great clinical importance, particularly as it impacts disease progression outcomes. Individuals rheumatic diseases (RDs), including rheumatoid arthritis, systemic sclerosis, spondyloarthritides, lupus erythematosus, fibromyalgia, myositis, or vasculitis, exhibit high prevalence sarcopenia, which exacerbates their symptoms contributes to poorer Chronic inflammation influences tissue degradation, causing decline in performance. Apart from apparent manifestations, patients RDs also use pharmacological treatments that negatively impact further, increasing risk sarcopenia. Nutrition (diet dietary supplements) exercise interventions have been recommended protective measures they may mitigate its adverse events. The present narrative review seeks explore methods used assess RDs, among them, challenges faced individuals, while critically assessing appropriateness limitations current assessment tools context RDs.

Language: Английский

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Sarcopenia in rheumatoid arthritis: choose your weapons wisely

Clinical Rheumatology, Journal Year: 2024, Volume and Issue: 43(7), P. 2363 - 2364

Published: May 13, 2024

Language: Английский

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Critical roles of IL-6 signaling in myogenesis of human adipose-derived mesenchymal stem cells

Research Square (Research Square), Journal Year: 2024, Volume and Issue: unknown

Published: Dec. 17, 2024

Background: Sarcopenia is a progressive skeletal muscle disease that most common in older adults. With no specific pharmacological therapies for sarcopenia, the development of specifically focus on regeneration an urgent issue. Aim to find novel myogenic cytokine and its signaling pathway promotes differentiation human adipose-derived mesenchymal stem cells (ADSCs) – potential source new precursor into myoblasts. Methods: An array kit was used detect cytokines produced by ADSCs. After treating ADSCs with DNA methyltransferase inhibitor 5-Aza-2’-deoxycytidine (5-aza-C) different JAK inhibitors, MyHC1, myodifferentiation marker, detected immunofluorescence staining reverse transcription‐quantitative polymerase chain reaction (RT-qPCR). The expression status molecules determined Western blotting recruitment transcription factors MYOG promoter chromatin immunoprecipitation (ChIP). Results: IL-6 at high concentrations culture supernatant stimulated 5-aza-C became strongly positive MyHC1 day 21 post-stimulation. When co-stimulated IL-6/sIL-6R, expressed MYOG as early 14 Co-stimulation IL-6/sIL-6R resulted phosphorylation STAT1 STAT3. addition JAK2 inhibitor, but not JAK1/3 abolished positivity during myogenesis process STAT1, STAT3, promoter. Myoblast induced stimulation enhanced activation IL-6/JAK2/STAT1/MYOG pathway. Conclusions: Therefore, sustained IL-6/JAK2/STAT1 may serve important driver regeneration, providing therapeutic basis addressing sarcopenia.

Language: Английский

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