HORMONES, Journal Year: 2020, Volume and Issue: 19(4), P. 485 - 496
Published: June 1, 2020
Language: Английский
Biomedicine & Pharmacotherapy, Journal Year: 2024, Volume and Issue: 174, P. 116487 - 116487
Published: March 21, 2024
Melatonin is a highly conserved molecule produced in the human pineal gland as hormone. It known for its essential biological effects, such antioxidant activity, circadian rhythm regulator, and immunomodulatory effects. The gut one of primary sources melatonin. microbiota helps produce melatonin from tryptophan, has been shown to have beneficial effect on barrier function microbial population. Dysbiosis intestinal associated with bacterial imbalance decreased metabolites, including In this way, low levels may be related several diseases. both preventive therapeutic effects against various conditions, neurological diseases Alzheimer's disease, Parkinson's multiple sclerosis. This review was aimed discuss role body, describe possible relationship between production, well potential
Language: Английский
Citations
18
Biomolecules, Journal Year: 2020, Volume and Issue: 10(8), P. 1158 - 1158
Published: Aug. 7, 2020
Neurodegenerative diseases are the second most common cause of death and characterized by progressive impairments in movement or mental functioning central peripheral nervous system. The prevention neurodegenerative disorders has become an emerging public health challenge for our society. Melatonin, a pineal hormone, various physiological functions brain, including regulating circadian rhythms, clearing free radicals, inhibiting biomolecular oxidation, suppressing neuroinflammation. Cumulative evidence indicates that melatonin wide range neuroprotective roles pathophysiological mechanisms signaling pathways. Moreover, levels decreased patients with diseases. In this review, we summarize current knowledge on regulation, molecular biological such as Alzheimer’s disease, Parkinson’s Huntington’s amyotrophic lateral sclerosis, vascular dementia multiple sclerosis. We also discuss clinical application disorders. This information will lead to better understanding regulation brain provide therapeutic options treatment
Language: Английский
Citations
108
Inflammopharmacology, Journal Year: 2022, Volume and Issue: 30(5), P. 1569 - 1596
Published: June 5, 2022
Language: Английский
Citations
57
Seminars in Immunopathology, Journal Year: 2022, Volume and Issue: 44(2), P. 209 - 224
Published: March 1, 2022
Abstract The adaptive arm of the immune system facilitates recognition specific foreign pathogens and, via action T and B lymphocytes, induces a fine-tuned response to target pathogen develop immunological memory. functionality exhibits daily 24-h variation both in homeostatic processes (such as lymphocyte trafficking development subsets) responses challenge. Here, we discuss how circadian clock exerts influence over function system, considering roles cell intrinsic clockwork machinery extrinsic rhythmic signals. Inappropriate or misguided actions can lead autoimmune diseases such rheumatoid arthritis, ulcerative colitis multiple sclerosis. Growing evidence indicates that disturbance has negative impact on progression these chronic inflammatory examine current understanding clock-immune interactions setting conditions. A greater appreciation control immunity will facilitate further mechanisms driving disease states drive improvements diagnosis treatment diseases.
Language: Английский
Citations
47
Pharmaceutics, Journal Year: 2023, Volume and Issue: 15(1), P. 212 - 212
Published: Jan. 7, 2023
Neurodegenerative diseases are caused by the gradual loss of neurons’ function. These neurological illnesses remain incurable, and current medicines only alleviate symptoms. Given social economic burden rising frequency neurodegenerative diseases, there is an urgent need for development appropriate therapeutics. Natural compounds gaining popularity as alternatives to synthetic drugs due their neuroprotective properties higher biocompatibility. While natural compounds’ therapeutic effects disease treatment have been investigated in numerous vitro vivo studies, few moved clinical trials. This article provides first systematic review trials evaluating safety efficacy five most prevalent disorders: Alzheimer’s disease, Parkinson’s multiple sclerosis, amyotrophic lateral Huntington’s disease.
Language: Английский
Citations
28
Journal of Immunology Research, Journal Year: 2024, Volume and Issue: 2024, P. 1 - 31
Published: Jan. 4, 2024
Multiple sclerosis (MS) is a neurodegenerative autoimmune disease characterized by the destruction of myelin sheath neuronal axon in central nervous system. Many risk factors, including environmental, epigenetic, genetic, and lifestyle are responsible for development MS. It has long been thought that only adaptive immune cells, especially autoreactive T pathophysiology; however, recent evidence indicated innate cells also highly involved initiation progression. Here, we compile available data regarding role play MS, drawn from both human animal research. While B lymphocytes, chiefly enhance MS pathology, regulatory (Tregs) may serve more protective role, as can depending on context location. Cells immunity, macrophages, microglia, astrocytes, dendritic natural killer (NK) eosinophils, mast varied roles. In addition, there involvement innate-like such γδ NKT MAIT crucial contributors to pathophysiology. unclear which these cell subsets onset or progression mechanisms due their plastic nature, change properties functions microenvironmental exposure response neural networks damage control. This highlights need multipronged approach, combining stringently designed clinical with carefully controlled vitro vivo research findings, identify underlying so effective therapeutics be developed.
Language: Английский
Citations
9
Heliyon, Journal Year: 2024, Volume and Issue: 10(2), P. e24266 - e24266
Published: Jan. 1, 2024
BackgroundMelatonin is an indoleamine hormone secreted by the pineal gland at night and has essential role in regulating human circadian rhythms (the internal 24-h clock) sleep-wake patterns. However, it recently gained considerable attention for its demonstrated ability disease management. This review discusses major biological activities of melatonin, metabolites as nutritional supplements, bioavailability food sources.MethodsThe information acquisition process involved conducting a comprehensive search across academic databases including PubMed, Scopus, Wiley, Embase, Springer using relevant keywords. Only most recent, peer-reviewed articles published English language were considered inclusion.ResultsThe molecular mechanisms which melatonin induces therapeutic effects have been subject various studies.ConclusionWhile was initially understood to only regulate rhythms, recent studies indicate that far-reaching effect on organs physiological systems, such immunity, cardiovascular function, antioxidant defense, lipid hemostasis. As potent antioxidant, anti-cancer, anti-inflammatory, immunoregulatory agent, multiple applications proposed melatonin.
Language: Английский
Citations
9
Biochemical and Biophysical Research Communications, Journal Year: 2022, Volume and Issue: 605, P. 70 - 81
Published: March 17, 2022
Language: Английский
Citations
25
Antioxidants, Journal Year: 2023, Volume and Issue: 12(10), P. 1844 - 1844
Published: Oct. 10, 2023
The aim of this review is to explore the relationship between melatonin, free radicals, and non-excitatory amino acids, their role in stroke aging. Melatonin has garnered significant attention recent years due its diverse physiological functions potential therapeutic benefits by reducing oxidative stress, inflammation, apoptosis. been found mitigate ischemic brain damage caused stroke. By scavenging radicals damage, melatonin may help slow down aging process protect against age-related cognitive decline. Additionally, acids have shown possess neuroprotective properties, including antioxidant anti-inflammatory aging-related conditions. They can attenuate modulate calcium homeostasis, inhibit apoptosis, thereby safeguarding neurons induced processes. intracellular accumulation certain could promote harmful effects during hypoxia-ischemia episodes thus, blockade acid transporters involved be an alternative strategy reduce damage. On other hand, specifically mitochondrial reactive oxygen nitrogen species, accelerates cellular senescence contributes Recent research suggests a complex interplay actions converge on multiple pathways, regulation modulation reduction inflammation. These mechanisms collectively contribute preservation neuronal integrity functions, making them promising targets for interventions disorders.
Language: Английский
Citations
14
ACS Chemical Neuroscience, Journal Year: 2023, Volume and Issue: 14(4), P. 527 - 553
Published: Feb. 1, 2023
Multiple sclerosis (MS) is a chronic inflammatory and neurodegenerative disease of the central nervous system (CNS). Although emerging evidence has shown that changes in neurotransmitter levels synaptic gap may contribute to pathophysiology MS, their specific role not been elucidated yet. In this review, we aim analyze preclinical clinical on structural functional neurotransmitters MS critically discuss potential pathophysiology. Preclinical studies have demonstrated alterations glutamate metabolism pathophysiology, by causing excitotoxic neuronal damage. Dysregulated interaction between GABA results loss. The GABAergic also plays an important role, regulating activity plasticity neural networks. Targeting GABAergic/glutamatergic transmission be effective fatigue cognitive impairment MS. Acetylcholine (ACh) dopamine can affect T-mediated responses, thereby being implicated MS-related neuroinflammation. Also, melatonin might frequency relapses sleep-wake cycle. Increased nitric oxide lesions patients associated with axonal degeneration. Therefore, imbalance future are needed for our deeper understanding
Language: Английский
Citations
13