Vocabulary knowledge as a reliable proxy of cognitive reserve in multiple sclerosis: a validation study

Neurological Sciences, Journal Year: 2024, Volume and Issue: 45(8), P. 3931 - 3938

Published: Feb. 28, 2024

Abstract Introduction The present study aimed to explore the suitability of vocabulary knowledge (VOC) test as an accurate and reliable proxy cognitive reserve (CR) by evaluating its psychometric properties discrimination accuracy compared with other CR measures in multiple sclerosis (MS). Methods Sixty-eight consecutive people (pwMS), followed at our MS outpatient clinic, completed a clinical evaluation neuropsychological assessment including: VOC, Brief Repeatable Battery Neuropsychological Tests (BRB-N), Cognitive Reserve Index Questionnaire (CRIq), Beck Depression Inventory-II, State-Trait Anxiety Inventory. Reliability, convergent divergent validity, VOC were assessed using educational level reference standard. possible effects sociodemographic factors on their role predicting global status also explored. Results demonstrated good internal consistency (Cronbach’s α = 0.894) adequate construct validity. It showed acceptable between pwMS high low CR, comparable CRIq score. Education strongly affected scores, which turn independent features. emerged predictor together MS-related disability. Conclusion We validity measure pwMS. Thus, may be estimated fixed objective measures, brain pathology Early estimation help clinicians identify higher risk decline plan strict monitoring interventions.

Language: Английский

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A Lightweight Multi-Mental Disorders Detection Method Using Entropy-Based Matrix from Single-Channel EEG Signals

Brain Sciences, Journal Year: 2024, Volume and Issue: 14(10), P. 987 - 987

Published: Sept. 28, 2024

Background: Mental health issues are increasingly prominent worldwide, posing significant threats to patients and deeply affecting their families social relationships. Traditional diagnostic methods subjective delayed, indicating the need for an objective effective early diagnosis method. Methods: To this end, paper proposes a lightweight detection method multi-mental disorders with fewer data sources, aiming improve procedures enable patient detection. First, proposed takes Electroencephalography (EEG) signals as acquires brain rhythms through Discrete Wavelet Decomposition (DWT), extracts approximate entropy, fuzzy permutation sample entropy establish entropy-based matrix. Then, six kinds of conventional machine learning classifiers, including Support Vector Machine (SVM), k-Nearest Neighbors (kNN), Naive Bayes (NB), Generalized Additive Model (GAM), Linear Discriminant Analysis (LDA), Decision Tree (DT), adopted matrix achieve task. Their performances assessed by accuracy, sensitivity, specificity, F1-score. Concerning these experiments, three public datasets schizophrenia, epilepsy, depression utilized validation. Results: The analysis results from identifies representative single-channel (schizophrenia: O1, epilepsy: F3, depression: O2), satisfying classification accuracies (88.10%, 75.47%, 89.92%, respectively) minimal input. Conclusions: Such impressive when considering sources concern, which also improves interpretability features in EEG, providing reliable approach advancing insights into underlying mechanisms pathological states.

Language: Английский

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Modeling of Shoulder–Elbow Movement with Exponential Parameter Identification During Walking Gaits for Healthy Subjects and Patients with Parkinson’s Disease

Applied Sciences, Journal Year: 2025, Volume and Issue: 15(2), P. 668 - 668

Published: Jan. 11, 2025

Background: This paper aims to complement the latest contribution in literature that provides estimates of physiological parameters a dynamic model for elbow time profile during walking while linking them neurodegenerative disorder (Parkinsons’s disease) characterized by motor symptoms. An upper limb is here proposed which an active contractile element included within model, viewing arm as double pendulum system and muscles represented Kelvin–Voight system. All characterizing both shoulder each subject are estimated via gradient-like identifier whose exponential convergence properties determined non-anticipative Lyapunov function, ensuring robustness features. Methods: Joint angle data from different subjects (healthy patients with Parkinson’s have been recorded using IMU sensor compared joint angles obtained means was adapted available anthropometric knowledge relying on parameters. Results: Experiments show reconstruction profiles can be definitely achieved through procedure stiffness turning out constitute objective quantitative indices muscle (as pivotal symptom pathology), able track changes due therapy. Conclusions: The same actually capture main features movement pathological) subjects, its parameters, turn, nature progress pathology.

Language: Английский

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Lack of pre-movement facilitation as neurophysiological hallmark of fatigue in patients with Parkinson's disease: A single pulse TMS study

Neurobiology of Disease, Journal Year: 2025, Volume and Issue: unknown, P. 106878 - 106878

Published: March 1, 2025

Language: Английский

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Systematic review and meta-analysis of polycystic ovary syndrome and mental health among Black Asian Minority Ethnic populations

Published: Feb. 6, 2025

Background: Polycystic ovary syndrome (PCOS) is a common, chronic gynaecological condition impacting women of reproductive age. Women with PCOS have hormonal, ovulatory, and metabolic dysfunction resulting in multiple symptoms. The correlation between hormonal disbalance the impact on women’s mental health (MH) has been researched for decades. However, prevalence among different ethnicities not fully evaluated. Aim: aim this study was to explore minority ethnic populations. Methods: A systematic methodology developed, protocol published PROSPERO (CRD42020210863); moreover, review publications 1st January 1990 30th 2021 conducted. Multiple electronic databases were explored using keywords MeSH terms. finalised dataset analysed statistical methods such as random-effect models, subgroup analysis, sensitivity analysis. These used determine variables PND, anxiety, PTSD, stress. Results: We included 30 studies reporting 3,944 women. majority addressed depression, common Studies showed fair poor methodological quality both observational Randomised Clinical Trials (RCTs). Overall, 17% (95% CI: 7% 29%) examined had clinical diagnosis major or severe depression; 33% 26% 40%) elevated depressive symptoms 41% 28% 54%) reported anxiety symptoms; 31% 15% 51%) form symptomatology taking psychiatric medication and/or depression. use various tools assess reasons substantial heterogeneity across studies. Conclusions: associated an increased risk disorders, including other conditions. Approximately 30% individuals are While BAME populations account about 20% most samples studied, stratification by ethnicity rarely attempted design makes it difficult elucidate MH communities.

Language: Английский

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The clinical profile of men with premature ejaculation at presentation has changed over the last fifteen years: picture from a longitudinal study

International Journal of Impotence Research, Journal Year: 2025, Volume and Issue: unknown

Published: March 25, 2025

Language: Английский

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The Perception of Trustworthiness and Emotional Identification in Women Experiencing Intimate Partner Violence: A Behavioral Pilot Study

Brain Sciences, Journal Year: 2025, Volume and Issue: 15(5), P. 429 - 429

Published: April 23, 2025

Background: Research indicates that traumatic events, such as interpersonal violence, can significantly affect how individuals perceive facial characteristics and assess trust. This study aims to explore trustworthiness emotional perception in women experiencing intimate partner violence (IPV). Methods: Twenty-four who have experienced IPV twenty-four control participants completed an online task. They rated the of male female faces, chose more trustworthy face a pairwise task, identified emotions displayed by faces. Results: The results revealed survivors showed lower accuracy judgments, particularly for recognizing fear compared group. Conclusions: These preliminary findings, constrained limited sample size, are discussed context Pathological Affective Dependence theory perceptual model social perception, shedding light on complex interplay between trauma, processing.

Language: Английский

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EEG Biofeedback Decreases Theta and Beta Power While Increasing Alpha Power in Insomniacs: An Open-Label Study

Brain Sciences, Journal Year: 2023, Volume and Issue: 13(11), P. 1542 - 1542

Published: Nov. 2, 2023

Insomnia, often associated with anxiety and depression, is a prevalent sleep disorder. Biofeedback (BFB) treatment can help patients gain voluntary control over physiological events such as by utilizing electroencephalography (EEG) electromyography (EMG) power. Previous studies have rarely predicted biofeedback efficacy measuring the changes in relative EEG power; therefore, we investigated clinical of for insomnia its potential neural mechanisms. We administered to 82 insomnia, whom 68 completed 10 sessions 14 20 sessions. The average age participants was 49.38 ± 12.78 years, 26 men 56 women. Each session consisted 5 min EMG 30 feedback, 2 data recorded before after session. Sessions were conducted every other day, four scale measures taken first, fifth, tenth twentieth After treatment, scores on Pittsburgh Sleep Quality Index (PSQI) significantly reduced compared those (-5.5 1.43,t = -3.85, p 0.006), Beck Depression Inventory (BDI-II) (-7.15 2.43, t -2.94, 0.012) State-Trait Anxiety (STAI) (STAI-S: -12.36 3.40, -3.63, 0.003; STAI-T: -9.86 2.38, -4.41, 0.001) lower than treatment. Beta theta power (F 6.25, 0.014; F 11.91, 0.001). Alpha increased but difference not prominently significant (p > 0.05). activity decreased 2.11, 0.015). Our findings suggest that BFB based alpha prefrontal relieves well depression may be power, beta

Language: Английский

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Evaluation of apathy in non-clinical populations: validation, psychometric properties, and normative data of the Italian version of Apathy-Motivation Index (AMI)

Neurological Sciences, Journal Year: 2023, Volume and Issue: 44(9), P. 3099 - 3106

Published: April 3, 2023

Evaluation of apathy in non-clinical populations is relevant to identify individuals at risk for developing cognitive decline later stages life, and it should be performed with questionnaires specifically designed healthy individuals, such as the Apathy-Motivation Index (AMI); therefore, aim present study was validate AMI a Italian population, provide normative data scale.Data collection using survey completed by 500 participants; DAS, MMQ-A, BIS-15, PHQ-9, GAD-7 were used investigate convergent divergent validity. Internal consistency factorial structure also evaluated. A regression-based procedure receiver operating characteristics (ROC) analyses evaluate influence socio-demographic variables on scores adjusting factors three cut-offs detection mild, moderate, severe apathy.The version included 17 items (one item removed because not internally consistent) demonstrated good psychometric properties. The three-factor confirmed. Multiple regression analysis revealed no effect sociodemographic total score. ROC 1.5, 1.66, 2.06 through Youden's J statistic detect apathy, respectively.The reported similar properties, structure, original scale. This may help researchers clinicians people address them specific interventions lower their levels.

Language: Английский

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Validation of the Italian version of the Questionnaire for Impulsive-Compulsive Disorders in Parkinson’s Disease-Rating Scale (QUIP-RS) in an Italian Parkinson’s disease cohort

Neurological Sciences, Journal Year: 2024, Volume and Issue: 45(7), P. 3153 - 3161

Published: Jan. 17, 2024

Abstract Introduction Impulse control disorders (ICDs) frequently occur in Parkinson’s disease (PD), and an early identification is essential to prevent severe psychosocial consequences. The Questionnaire for Impulsive-Compulsive Disorders Disease–Rating Scale (QUIP-RS) has been developed evaluate the severity of ICDs along with a range impulsive-compulsive behaviors (ICBs) PD; however, its Italian version not yet validated. Methods One hundred consecutive outpatients PD were administered QUIP-RS brief neuropsychological assessment global cognitive status scales measure depression, apathy impulsive disorders. We evaluated internal consistency, convergent divergent validity, factorial structure QUIP-RS. also explored possible association between scores clinical factors dopaminergic medication. Results Subsyndromal manifestations observed 54% patients, one four (22%) reported two or more related behaviors. demonstrated good consistency (Cronbach’s alpha = 0.806) construct reflected different ICBs domains. No emerged aspects Conclusion provided, first time, translation feasibility research settings. Severity was independent medication, underlining need adopt broader perspective on their etiopathology PD.

Language: Английский

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