Cerebrovascular markers of WMH and infarcts in ADNI: A historical perspective and future directions DOI Creative Commons
Pauline Maillard, Evan Fletcher, Owen Carmichael

et al.

Alzheimer s & Dementia, Journal Year: 2024, Volume and Issue: unknown

Published: Nov. 13, 2024

Abstract White matter hyperintensities (WMH) and infarcts found on magnetic resonance imaging (MR infarcts) are common biomarkers of cerebrovascular disease. In this review, we summarize the methods, publications, conclusions stemming from Alzheimer's Disease Neuroimaging Initiative (ADNI) related to these measures. We combine analysis WMH MR infarct data across three main ADNI cohorts with a review existing literature discussing new methodologies scientific findings derived data. Although inclusion criteria were designed minimize vascular risk factors disease, all consistent trends increasing volumes associated advancing age, female sex, cognitive impairment. ADNI, initially proposed as study investigate AD pathology, has also helped elucidate impact asymptomatic brain injury cognition within cohort relatively free Future work will emphasize additional biomarkers. Highlights (WMHs) age likely reflect among older individuals. lesser extent, (MR) infarcts, affect for transition WMHs present, even participants highly selected have disease (AD) primary pathology. burden in is greater individuals impairment been neurodegenerative markers cerebral amyloidosis. The negative additive effects appear select populations, future biomarker needs further explore relationship.

Language: Английский

Impact of enlarged perivascular spaces in the basal ganglia on gait in cerebral small vessel disease DOI Creative Commons

Shiyi Yang,

Jiwei Jiang, Linlin Wang

et al.

Aging Clinical and Experimental Research, Journal Year: 2025, Volume and Issue: 37(1)

Published: April 30, 2025

Language: Английский

Citations

0
Cerebrovascular markers of WMH and infarcts in ADNI: A historical perspective and future directions DOI Creative Commons
Pauline Maillard, Evan Fletcher, Owen Carmichael

et al.

Alzheimer s & Dementia, Journal Year: 2024, Volume and Issue: unknown

Published: Nov. 13, 2024

Abstract White matter hyperintensities (WMH) and infarcts found on magnetic resonance imaging (MR infarcts) are common biomarkers of cerebrovascular disease. In this review, we summarize the methods, publications, conclusions stemming from Alzheimer's Disease Neuroimaging Initiative (ADNI) related to these measures. We combine analysis WMH MR infarct data across three main ADNI cohorts with a review existing literature discussing new methodologies scientific findings derived data. Although inclusion criteria were designed minimize vascular risk factors disease, all consistent trends increasing volumes associated advancing age, female sex, cognitive impairment. ADNI, initially proposed as study investigate AD pathology, has also helped elucidate impact asymptomatic brain injury cognition within cohort relatively free Future work will emphasize additional biomarkers. Highlights (WMHs) age likely reflect among older individuals. lesser extent, (MR) infarcts, affect for transition WMHs present, even participants highly selected have disease (AD) primary pathology. burden in is greater individuals impairment been neurodegenerative markers cerebral amyloidosis. The negative additive effects appear select populations, future biomarker needs further explore relationship.

Language: Английский

Citations

0