Unveiling the Hidden Link: Stomach Disease as a Risk Factor for Knee Osteoarthritis DOI Creative Commons
Xing Yang,

Xi Yang,

Ping Li

et al.

Research Square (Research Square), Journal Year: 2024, Volume and Issue: unknown

Published: Nov. 14, 2024

Abstract Background The knee joint is one of the most frequently affected joints in osteoarthritis (OA). However, specific connection between gastric diseases and occurrence (KOA) currently unclear. objective this study to explore potential association KOA using China Health Retirement Longitudinal Study (CHARLS) database. Methods A total 1053 subjects with complete information 2018 from CHARLS database were included. First, baseline characteristics these (covariates such as gender, residence, smoke) compared. Then, relationship stomach was explored through 3 weighted multivariate logistic regression models. Afterwards, risk stratification analyses taken further confirm stability correlation disease different populations. receiver operating characteristic (ROC) curve model plotted verify predictive efficiency risk. Results we divided into 2 groups: group (n = 71) control 982). table revealed that substantial differences heart attack, kidney illness, disease, well health status groups. Model 1 had an odds ratio (OR) 3.05 (95% confidence interval (CI) 1.75–5.30, P < 0.001). After adjusting for location, smoke, 2's OR 3.02 CI 1.73–5.28, P 0.001), while 3's 2.48 1.37–4.47, 0.002). models demonstrated significantly associated a factor KOA, other covariates did not change relationship. Risk indicated stable across area under (AUC) 0.722, indicating good accuracy. Conclusion In study, furtherly certified which provided reference analysis them.

Language: Английский

Greater Symptom Burden and Poorer Quality of Life Outcomes Are Associated With The Co-Occurrence of Anxiety and Depression During Cancer Chemotherapy DOI Creative Commons

Alejandra Calvo‐Schimmel,

Marilyn J. Hammer, Yvette P. Conley

et al.

Seminars in Oncology Nursing, Journal Year: 2025, Volume and Issue: unknown, P. 151809 - 151809

Published: Feb. 1, 2025

Anxiety and depression are common symptoms in oncology patients undergoing chemotherapy. Study purpose was to evaluate for differences severity of (ie, fatigue, energy, sleep disturbance, cognitive function, pain) quality life (QOL) outcomes among three subgroups outpatients with distinct joint anxiety profiles. Oncology (N = 1328) completed measures state depression, six times over two cycles Latent profile analysis done identify AND Patients trait anxiety, morning evening pain, as well generic disease-specific QOL at enrollment. Differences the classes symptom scores were evaluated using parametric non-parametric tests. Three profiles identified named: Low Depression (57.5%, Both Low), Moderate (33.7%, Moderate), High (8.8%, High). All showed a "dose-response effect" worsened, all increased). Likewise, both general (except spiritual well-being) measures, decreased worsened. Compared classes, other reported lower well-being domain. More than 40% receiving chemotherapy experience moderate high levels depression. These report an extremely burden significant decrements domains QOL. Clinicians need perform comprehensive assessments during In addition, referrals targeted interventions needed manage multiple improve patients'

Language: Английский

Citations

0
Protein hydrolysate from Atlantic salmon (Salmo salar) improves aging-associated neuroinflammation and cognitive decline in rats by reshaping the gut microbiota and Th17/Treg balance DOI Creative Commons

Mei-Qi Guan,

Yu Lian,

Hong Gu

et al.

International Journal of Biological Macromolecules, Journal Year: 2025, Volume and Issue: 306, P. 141270 - 141270

Published: Feb. 19, 2025

Language: Английский

Citations

0
The Neurobehavioral Impact of Zinc Chloride Exposure in Zebrafish: Evaluating Cognitive Deficits and Probiotic Modulation DOI Creative Commons
Mihaela Ene, Alexandra Săvucă,

Alin-Stelian Ciobica

et al.

Toxics, Journal Year: 2025, Volume and Issue: 13(3), P. 193 - 193

Published: March 8, 2025

Zinc contamination in aquatic environments has become a growing concern due to its potential bioaccumulate and induce neurotoxic effects organisms. As an essential trace element, zinc plays crucial role various physiological processes, but excessive exposure can disrupt the gut–brain axis, leading cognitive behavioral impairments. Recent studies have suggested that probiotics may offer protective against environmental neurotoxins by modulating gut microbiota associated neurological functions. The zebrafish (Danio rerio) emerged as valuable model organism for studying biological mechanisms underlying neurotoxicity therapeutic interventions. This study aimed assess of on impairments induced chloride (ZnCl2) zebrafish. Specifically, were exposed ZnCl2 at concentrations 0.5 mg/L 1.0 96 h, followed 7-day post-exposure period (Bifidobacterium longum, Bifidobacterium animalis lactis, Lactobacillus rhamnosus). these is already known neuromotor deficits resembling Alzheimer’s disease-like symptoms models, making it suitable evaluating neuroprotective probiotics. Behavioral assessments including sociability tests along with short- long-term memory evaluations conducted using EthoVision XT 16 software. Memory demonstrated impaired functions, while probiotic treatment did not significantly ameliorate deficits. In social behavior test, resulted marked decrease sociability, whereas significant changes. However, administration following intoxication exhibited anxiolytic effect These findings suggest exhibit partial neurobehavioral benefits chloride-induced toxicity, particularly mitigating anxiety-like behaviors rather than Further investigations are needed elucidate precise which interact axis context heavy metal neurotoxicity.

Language: Английский

Citations

0
Unveiling the Hidden Link: Stomach Disease as a Risk Factor for Knee Osteoarthritis DOI Creative Commons
Xing Yang,

Xi Yang,

Ping Li

et al.

Research Square (Research Square), Journal Year: 2024, Volume and Issue: unknown

Published: Nov. 14, 2024

Abstract Background The knee joint is one of the most frequently affected joints in osteoarthritis (OA). However, specific connection between gastric diseases and occurrence (KOA) currently unclear. objective this study to explore potential association KOA using China Health Retirement Longitudinal Study (CHARLS) database. Methods A total 1053 subjects with complete information 2018 from CHARLS database were included. First, baseline characteristics these (covariates such as gender, residence, smoke) compared. Then, relationship stomach was explored through 3 weighted multivariate logistic regression models. Afterwards, risk stratification analyses taken further confirm stability correlation disease different populations. receiver operating characteristic (ROC) curve model plotted verify predictive efficiency risk. Results we divided into 2 groups: group (n = 71) control 982). table revealed that substantial differences heart attack, kidney illness, disease, well health status groups. Model 1 had an odds ratio (OR) 3.05 (95% confidence interval (CI) 1.75–5.30, P < 0.001). After adjusting for location, smoke, 2's OR 3.02 CI 1.73–5.28, P 0.001), while 3's 2.48 1.37–4.47, 0.002). models demonstrated significantly associated a factor KOA, other covariates did not change relationship. Risk indicated stable across area under (AUC) 0.722, indicating good accuracy. Conclusion In study, furtherly certified which provided reference analysis them.

Language: Английский

Citations

0