The effectiveness of theta burst stimulation for motor recovery after stroke: a systematic review DOI Creative Commons
Yuru Fu, Chengshuo Wang, Linli Zhang

et al.

European journal of medical research, Journal Year: 2024, Volume and Issue: 29(1)

Published: Nov. 29, 2024

Stroke is the second leading cause of death and third disability worldwide. Motor dysfunction a common sequela, which seriously affects lives patients. Theta burst stimulation (TBS) new transcranial magnetic therapy for improving motor after stroke. However, there remains lack studies on mechanism, theoretical model, effectiveness TBS in following This paper provides comprehensive overview assessment current impact rehabilitation stroke analyzes potential factors contributing to treatment effect disparities. The aim offer recommendations further refining approach subsequent clinical while also furnishing evidence devising tailored plans study was conducted PRISMA guidelines. PubMed, Embase, Web Science, Cochrane Library were searched systematically from establishment database February 2024. Relevant using treat patients with will be included. Data characteristics, interventions, outcome measures, primary outcomes extracted. Modified Downs Black Checklist used assess bias included studies, narrative synthesis key findings finally conducted. specific mechanism has not been fully elucidated, but it generally believed that can improve functional prognosis by regulating cortical excitability, inducing neural network reorganization, cerebral circulation metabolism. Currently, most relevant are based interhemispheric inhibition model (IHI), vicariation bimodal balance-recovery model. Many have verified function patients, therapeutic some controversial. Our results show good more large-scale, high-quality, multicenter still necessary future clarify explore optimal treatment.

Language: Английский

Effect of intermittent theta burst stimulation combined with acoustic startle priming motor training on upper limb motor function and neural plasticity in stroke individuals: study protocol for a randomised controlled proof-of-concept trial DOI Creative Commons
Yu Chen, Nan Xia, Jinghong Li

et al.

BMJ Open, Journal Year: 2025, Volume and Issue: 15(1), P. e090049 - e090049

Published: Jan. 1, 2025

Introduction Stroke is a major cause of acquired disability globally, yet the neural mechanisms driving motor recovery post-stroke remain elusive. Recent research has underscored growing significance subcortical pathways in plasticity and control. Among these, cortico-reticulospinal tract (CRST) gained attention rehabilitation due to its unique ascending descending structural features as well cellular properties which position it an excellent candidate compensate for inadequate control post-stroke. However, optimal strategies harness CRST unknown. Non-invasive modulation presents promising though challenging, therapeutic opportunity. Acoustic startle priming (ASP) training intermittent theta burst stimulation (iTBS) are emerging potential methods regulate function. This study aims investigate feasibility segmentally modulating cortico-reticular reticulospinal tracts through ASP iTBS while evaluating resulting effects. Methods analysis randomised, blinded interventional trial with three parallel groups. A total 36 eligible participants will be randomly assigned one groups: (1) iTBS+ASP group, (2) iTBS+non-ASP (3) sham group. The comprises four phases: baseline assessment, post-first intervention assessment after 3 weeks 4-week follow-up. primary outcomes changes Fugl-Meyer Assessment-Upper Extremity Modified Ashworth Scale 3-week intervention. Secondary include neurophysiological metrics neuroimaging results from diffusion tensor imaging resting-state functional MRI. Ethics dissemination registered Chinese Clinical Trial Registry (Registration No. ChiCTR2400085220) Medical Committee Tongji Hospital, affiliated College, Huazhong University Science Technology No.TJ-IRB20231109). It conducted Departments Rehabilitation Medicine Radiology at Hospital Wuhan, China. findings disseminated peer-reviewed journal publications presentations scientific conferences. registration number ChiCTR2400085220.

Language: Английский

Citations

0
Comparative Effectiveness of Passive vs. Assistive Robotic Gait Training on Functional Recovery and Neuroplasticity Post-Stroke: A Randomized Controlled Trial DOI

Yun-Juan Xie,

Minsu Song, Xiaodan Ma

et al.

Research Square (Research Square), Journal Year: 2025, Volume and Issue: unknown

Published: May 9, 2025

Abstract Background Robot-assisted gait training (RAGT) has gained recognition as a promising therapeutic approach, offering high-intensity and repetitive training. Despite its potential, the clinical effectiveness ideal protocols continue to be subjects of debate. This study seeks compare impacts various RAGT modes on lower limb motor function recovery in stroke patients while exploring corresponding neural mechanisms. Methods A double-blind, randomized controlled trial was conducted aged 18 80 who had experienced their first unilateral accompanied by walking impairments. Participants were randomly assigned one three groups: (1) assistive mode combined with conventional therapies, (2) passive or (3) control group receiving only traditional rehabilitation. Outcomes evaluated using Fugl-Meyer Assessment for Lower Extremity (FMA-LE), Berg Balance Scale (BBS), Modified Barthel Index (MBI), Functional Ambulatory Category (FAC), functional near-infrared spectroscopy. Statistical analyses performed repeated measures ANOVA non-parametric tests where appropriate, statistical significance set at p < 0.05. Results Among 48 recruited, significant time effects observed across all groups FMA-LE scores (p 0.001). Notable improvements detected (MD = 2.688, 0.005) 3.667, 0.001), also demonstrating effect 1.789, 0.039). BBS improved groups; however, no differences noted between 0.106). Similarly, MBI showed without notable 0.286). Crucially, exhibited brain activation during tasks specific regions compared group, alongside interhemispheric connectivity differences. Conclusions All modalities effectively enhanced function, balance, daily living skills patients. Nevertheless, unique patterns pathways suggest distinct underlying mechanisms each approach. Trial Registration: The registered China Clinical Registration Center under registration number ChiCTR2100054527.

Language: Английский

Citations

0
Empowering Movement DOI
Garima Wadhwa, Badre Bossoufi

Advances in computational intelligence and robotics book series, Journal Year: 2025, Volume and Issue: unknown, P. 543 - 566

Published: May 9, 2025

The individuals with neurological conditions suffer from range of impairments in motor, sensory and autonomic systems the body leading to dependance on others reduced quality life. Conventional rehabilitations method though proven be effective but exhibit many limitations including long recovery time, not able work multiple domains altogether, time manpower consuming. Thus, integrating innovative solutions conventional rehabilitation strategies is need speed- up process as well evaluate real objective monitoring. One such solution in-cooperation wearable device rehabilitation. Wearables exoskeletal have diverse application field terms early prediction, diagnosis treatment main this chapter explore effectiveness wearables neurorehabilitation.

Language: Английский

Citations

0
The effectiveness of theta burst stimulation for motor recovery after stroke: a systematic review DOI Creative Commons
Yuru Fu, Chengshuo Wang, Linli Zhang

et al.

European journal of medical research, Journal Year: 2024, Volume and Issue: 29(1)

Published: Nov. 29, 2024

Stroke is the second leading cause of death and third disability worldwide. Motor dysfunction a common sequela, which seriously affects lives patients. Theta burst stimulation (TBS) new transcranial magnetic therapy for improving motor after stroke. However, there remains lack studies on mechanism, theoretical model, effectiveness TBS in following This paper provides comprehensive overview assessment current impact rehabilitation stroke analyzes potential factors contributing to treatment effect disparities. The aim offer recommendations further refining approach subsequent clinical while also furnishing evidence devising tailored plans study was conducted PRISMA guidelines. PubMed, Embase, Web Science, Cochrane Library were searched systematically from establishment database February 2024. Relevant using treat patients with will be included. Data characteristics, interventions, outcome measures, primary outcomes extracted. Modified Downs Black Checklist used assess bias included studies, narrative synthesis key findings finally conducted. specific mechanism has not been fully elucidated, but it generally believed that can improve functional prognosis by regulating cortical excitability, inducing neural network reorganization, cerebral circulation metabolism. Currently, most relevant are based interhemispheric inhibition model (IHI), vicariation bimodal balance-recovery model. Many have verified function patients, therapeutic some controversial. Our results show good more large-scale, high-quality, multicenter still necessary future clarify explore optimal treatment.

Language: Английский

Citations

1