Dynamics of respiratory virus transmission in children during and after COVID-19 outbreak control in Baiyin, China DOI
Biao Wang, Hui Zhang,

Shu Liang

et al.

Research Square (Research Square), Journal Year: 2025, Volume and Issue: unknown

Published: May 6, 2025

Abstract Purpose We aimed to study the changes in respiratory virus detection rates during control of COVID-19 outbreak and elucidate possible epidemiologic disturbances after lifting measures. Methods Severe acute infection (SARI) specimens hospitalized children were collected from 2021-2023 Baiyin, China. conducted real-time fluorescence quantitative PCR (RT-qPCR) detect various viruses, including influenza (IFV), human syncytial (HRSV), rhinovirus (HRV), parainfluenza (HPIV), metapneumovirus (HMPV), adenovirus (HADV), enterovirus (EV), coronavirus (HCoV). The results statistically analyzed by SPSS 26.0 software. Results A total 1353 nasopharyngeal swab with tract infections (ARTIs) between 2021 2023. male-to-female ratio was 1.49:1 overall viral rate 33.85% (458/1353). Data comparing two distinct periods: before measures (January 1, –December 6, 2022) (December 7, 2022 – December 31, 2023). No significant difference observed pathogen-positive periods without for age groups ≤1 year (OR: 0.986, 95% CI:0.960-1.013) 1-3 years 1.018, CI:0.997-1.060). However, differences found 3-6 (OR:1.097, CI:1.049-1.146) >6 (OR:1.099, 95%CI: 1.063-1.138) groups, as well males (OR:1.293, 95%CI:1.156-1.445) females 1.354, 95%CI:1.157-1.583). positive viruses increased significantly 27.84% 44.84% (OR:1.313, CI:1.198-1.438) Before measures, order virus-positive (HPIV) > (HRSV) (HAdV) (HRV) (HMPV) (EV) (HCoV) (IFV). After EV IFV HAdV HCoV HPIV HRV HMPV HRSV. Compared period a rightward shift peak time HRV, HMPV, HAdV, EV. (OR:1.090, 95%CI:1.059-1.122), (OR:1.102, 95%CI:1.064-1.141), (OR:1.043, 95%CI:1.017-1.070) significantly. A decrease seen HRSV (OR:0.965, 95%CI:0.946-0.985); non-significant (OR:0.971, 95%CI:0.943-1.001).and no (OR:1.019, 95%CI:0.989-1.032).and HADV (OR:1.028, 95%CI:0.999-1.059).Notably, rebounded January February Conclusions These findings help that social interventions can influence prevalence childhood unique historical period. implementation may have curbed spread viruses. Surveillance pathogens must be strengthened are lifted reduce risk affecting children's health.

Language: Английский

Dynamics of respiratory virus transmission in children during and after COVID-19 outbreak control in Baiyin, China DOI
Biao Wang, Hui Zhang,

Shu Liang

et al.

Research Square (Research Square), Journal Year: 2025, Volume and Issue: unknown

Published: May 6, 2025

Abstract Purpose We aimed to study the changes in respiratory virus detection rates during control of COVID-19 outbreak and elucidate possible epidemiologic disturbances after lifting measures. Methods Severe acute infection (SARI) specimens hospitalized children were collected from 2021-2023 Baiyin, China. conducted real-time fluorescence quantitative PCR (RT-qPCR) detect various viruses, including influenza (IFV), human syncytial (HRSV), rhinovirus (HRV), parainfluenza (HPIV), metapneumovirus (HMPV), adenovirus (HADV), enterovirus (EV), coronavirus (HCoV). The results statistically analyzed by SPSS 26.0 software. Results A total 1353 nasopharyngeal swab with tract infections (ARTIs) between 2021 2023. male-to-female ratio was 1.49:1 overall viral rate 33.85% (458/1353). Data comparing two distinct periods: before measures (January 1, –December 6, 2022) (December 7, 2022 – December 31, 2023). No significant difference observed pathogen-positive periods without for age groups ≤1 year (OR: 0.986, 95% CI:0.960-1.013) 1-3 years 1.018, CI:0.997-1.060). However, differences found 3-6 (OR:1.097, CI:1.049-1.146) >6 (OR:1.099, 95%CI: 1.063-1.138) groups, as well males (OR:1.293, 95%CI:1.156-1.445) females 1.354, 95%CI:1.157-1.583). positive viruses increased significantly 27.84% 44.84% (OR:1.313, CI:1.198-1.438) Before measures, order virus-positive (HPIV) > (HRSV) (HAdV) (HRV) (HMPV) (EV) (HCoV) (IFV). After EV IFV HAdV HCoV HPIV HRV HMPV HRSV. Compared period a rightward shift peak time HRV, HMPV, HAdV, EV. (OR:1.090, 95%CI:1.059-1.122), (OR:1.102, 95%CI:1.064-1.141), (OR:1.043, 95%CI:1.017-1.070) significantly. A decrease seen HRSV (OR:0.965, 95%CI:0.946-0.985); non-significant (OR:0.971, 95%CI:0.943-1.001).and no (OR:1.019, 95%CI:0.989-1.032).and HADV (OR:1.028, 95%CI:0.999-1.059).Notably, rebounded January February Conclusions These findings help that social interventions can influence prevalence childhood unique historical period. implementation may have curbed spread viruses. Surveillance pathogens must be strengthened are lifted reduce risk affecting children's health.

Language: Английский

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