Light emitting diodes technology-based photobiomodulation therapy (PBMT) for dermatology and aesthetics: Recent applications, challenges, and perspectives

Optics & Laser Technology, Journal Year: 2020, Volume and Issue: 135, P. 106698 - 106698

Published: Nov. 3, 2020

Language: Английский

---

Transcranial photobiomodulation changes topology, synchronizability, and complexity of resting state brain networks

Journal of Neural Engineering, Journal Year: 2021, Volume and Issue: 18(4), P. 046048 - 046048

Published: April 24, 2021

Abstract Objective . Transcranial photobiomodulation (tPBM) is a recently proposed non-invasive brain stimulation approach with various effects on the nervous system from cells to whole networks. Specially in neural network level, tPBM can alter topology and synchronizability of functional However, properties networks after are still poorly clarified. Approach Here, we employed electroencephalography different methods (conventional spectral) graph theory analysis track significant resting state The non-parametric statistical showed that just one short-term session over right medial frontal pole significantly change both topological (i.e. clustering coefficient, global efficiency, local eigenvector centrality) dynamical energy, largest eigenvalue, entropy) features Main results revealed reduce processing, centrality, laterality. Furthermore, increased centrality central electrode was observed. Significance These suggested facilitate information processing. On other hand, reduced stability complexity be considered association connectivity patterns among regions enhanced propagation Overall, suggest although decreases processing (especially hemisphere) disrupts network, but it increase level transferring network.

Language: Английский

---

Combination of Group Singular Value Decomposition and eLORETA Identifies Human EEG Networks and Responses to Transcranial Photobiomodulation

Frontiers in Human Neuroscience, Journal Year: 2022, Volume and Issue: 16

Published: May 10, 2022

Transcranial Photobiomodulation (tPBM) has demonstrated its ability to alter electrophysiological activity in the human brain. However, it is unclear how tPBM modulates brain electroencephalogram (EEG) networks and related cognition. In this study, we recorded 64-channel EEG from 44 healthy humans before, during, after 8-min, right-forehead, 1,064-nm or sham stimulation with an irradiance of 257 mW/cm 2 . data processing, a novel methodology by combining group singular value decomposition (gSVD) exact low-resolution electromagnetic tomography (eLORETA) was implemented performed on noise-free time series. The gSVD+eLORETA algorithm produced 11 gSVD-derived principal components (PCs) projected 2D sensor 3D source domain/space. These PCs took more than 70% weight entire signals were justified as networks. Finally, baseline-normalized power changes each network frequency band (delta, theta, alpha, beta gamma) quantified during first 4-min, second post tPBM/sham periods, followed comparisons frequency-specific between conditions. Our results showed that tPBM-induced increases alpha powers occurred at default mode network, executive control frontal parietal lateral visual network. Moreover, decompose into individual, independent facilitated better visualize significant decreases gamma tPBM. Many similarities found cortical locations SVD-revealed fMRI-identified resting-state This consistency may shed light mechanistic associations tPBM-modulated improved cognition outcomes.

Language: Английский

---

From functional neuroimaging to neurostimulation: fNIRS devices as cognitive enhancers

Behavior Research Methods, Journal Year: 2023, Volume and Issue: 56(3), P. 2227 - 2242

Published: July 28, 2023

Functional near-infrared spectroscopy (fNIRS) relies on (NIR) light for changes in tissue oxygenation. For decades, this technique has been used neuroscience to measure cortical activity. However, recent research suggests that NIR directed neural populations can modulate their activity through "photobiomodulation" (PBM). Yet, fNIRS is being exclusively as a measurement tool. By adopting cognitive tests sensitive prefrontal functioning, we show 'classical' device, placed correspondence of the cortices healthy participants, induces faster RTs and better accuracy some indexes considered. A well-matched control group, wearing same but inactive did not any improvement. Hence, our findings indicate 'standard' use devices generates PBM impacting cognition. The neuromodulatory power intrinsic so far completely overlooked, future studies will need take into account.

Language: Английский

---

Advanced Intervention Effects of Pulsed and Steady Transcranial Photobiomodulation on Sleep, Mood, and EEG Signal Regulation

Journal of Biophotonics, Journal Year: 2025, Volume and Issue: unknown

Published: March 18, 2025

ABSTRACT Background Transcranial photobiomodulation (tPBM) enhances cognitive and emotional states. We compared continuous‐wave (CW) pulsed‐wave (PW) tPBM effects on 24 healthy males. Method Participants received 630 nm at 95 mW/cm 2 for 10 min: Sham, CW, or PW (500 Hz). Outcomes were assessed using the Karolinska Sleepiness Scale (KSS) (for measuring sleepiness), State‐Trait Anxiety Inventory (STAI) assessing anxiety), Visual Analog (VAS) stress), Beck Depression Inventory‐II (BDI‐II) evaluating depressive symptoms), 32‐channel EEG baseline, treatment, rest phases. Results Paired t ‐tests showed significantly improved sleepiness, anxiety, stress, depression scores post‐intervention ( p < 0.05). ANOVA analyses indicated increased Alpha Gamma band power versus baseline Conclusion may improve outcomes modulate brain activity, offering therapeutic insights.

Language: Английский

---

Photobiomodulation effects on cognitive function — a systematic review and meta-analysis of randomized controlled trials

Lasers in Medical Science, Journal Year: 2025, Volume and Issue: 40(1)

Published: May 21, 2025

Language: Английский

---

Protocol for randomized controlled trial to evaluate the safety and feasibility of a novel helmet to deliver transcranial light emitting diodes photobiomodulation therapy to patients with Parkinson’s disease

Frontiers in Neuroscience, Journal Year: 2022, Volume and Issue: 16

Published: Aug. 17, 2022

Parkinson's disease (PD) is the second most common, progressive, and debilitating neurodegenerative associated with aging common movement disorder. Photobiomodulation (PBM), use of non-thermal light for therapeutic purposes using laser or emitting diodes (LED) an emerging non-invasive treatment a diverse range neurological conditions. The main objectives this clinical trial are to investigate feasibility, safety, tolerability, efficacy novel transcranial LED helmet device (the "PDNeuro") in alleviation symptoms PD.This 24-week, two-arm, triple-blinded randomized placebo-controlled "PDNeuro" Helmet, comparing active sham device. In survey, 40 PD participants Hoehn Yahr Stage I-III during ON periods will be enrolled randomly assigned into two groups. Both groups monitored weekly safety tolerability Helmet. Clinical signs assessed include mobility, fine motor skills cognition, data collected at baseline, 12 weeks, 24 weeks. Assessment tools TUG, UPDRS, MoCA all validated patients. Patient's adherence usage participant drop out weekly. At weeks both placebo crossover offered treatment. indicator "PDneuro" Helmet evidence sustained improvements non-motor obtained from self-reported changes, carer reporting changes objective reassessment by investigators. outcomes assist future larger design.[https://www.anzctr.org.au], identifier [12621001722886].

Language: Английский

---

Transcranial Photobiomodulation for the Treatment of Children with Autism Spectrum Disorder (ASD): A Retrospective Study

Children, Journal Year: 2022, Volume and Issue: 9(5), P. 755 - 755

Published: May 20, 2022

Children with Autism Spectrum Disorder (ASD) face several challenges due to deficits in social function and communication along restricted patterns of behaviors. Often, they also have difficult-to-manage disruptive At the moment, there are no pharmacological treatments for ASD core features. Recently, has been a growing interest non-pharmacological interventions ASD, such as neuromodulation. In this retrospective study, data reported analyzed from 21 patients (13 males, 8 females) an average age 9.1 (range 5−15), who received six months transcranial photobiomodulation (tPBM) at home using two protocols (alpha gamma), which, respectively, modulates alpha gamma bands. They were evaluated baseline, after three treatment Childhood Rating Scale (CARS), Home Situation Questionnaire-ASD (HSQ-ASD), Parenting Stress Index (APSI), Montefiore Einstein Rigidity Scale−Revised (MERS−R), Pittsburgh Sleep Quality (PSQI) SDAG, evaluate attention. Findings show that tPBM was associated reduction severity, shown by decrease CARS scores during intervention (p < 0.001). A relevant noncompliant behavior parental stress found. Moreover, behavioral cognitive rigidity well improvement attentional functions sleep quality. Limitations discussed future directions research.

Language: Английский

---

Pulsed transcranial photobiomodulation generates distinct beneficial neurocognitive effects compared with continuous wave transcranial light

Lasers in Medical Science, Journal Year: 2023, Volume and Issue: 38(1)

Published: Sept. 5, 2023

Language: Английский

---

Recent advances in light energy biotherapeutic strategies with photobiomodulation on central nervous system disorders

Brain Research, Journal Year: 2023, Volume and Issue: 1822, P. 148615 - 148615

Published: Oct. 14, 2023

Language: Английский

---