Cited by The role of bioactive compounds in the management of metabolic and alcohol-related liver disease

Dietary Influences on Gut Microbiota and Their Role in Metabolic Dysfunction-Associated Steatotic Liver Disease (MASLD) DOI

Sevag Hamamah,

Oana C. Iatcu,

Mihai Covașă

et al.

Nutrients, Journal Year: 2024, Volume and Issue: 17(1), P. 143 - 143

Published: Dec. 31, 2024

Metabolic dysfunction-associated steatotic liver disease (MASLD) is a major contributor to liver-related morbidity, cardiovascular disease, and metabolic complications. Lifestyle interventions, including diet exercise, are first line in treating MASLD. Dietary approaches such as the low-glycemic-index Mediterranean diet, ketogenic intermittent fasting, high fiber diets have demonstrated potential addressing dysfunction underlying this condition. The development progression of MASLD closely associated with taxonomic shifts gut microbial communities, relationship well-documented literature. Given importance primary treatment for MASLD, it important understand how microbiota their byproducts mediate favorable outcomes induced by healthy dietary patterns. Conversely, changes conferred unhealthy patterns Western may induce dysbiosis influence through promoting hepatic inflammation, up-regulating lipogenesis, dysregulating bile acid metabolism, increasing insulin resistance, causing oxidative damage hepatocytes. Although emerging evidence has identified links between microbiota, significant gaps remain understanding specific roles, metabolite pathways, host interactions, causal relationships. Therefore, review aims provide mechanistic insights into role microbiota-mediated processes analysis both contribution pathophysiology. By better elucidating interplay nutrients, processes, onset work identify new opportunities targeted interventions treat efficiently.

Language: Английский

Citations

Sodium alginate improves lipid disruption and alters the composition of the gut microbiota in farnesoid X receptor-null mice DOI

Masaaki Miyata,

K. Maeno,

Rei Takagi

et al.

International Journal of Food Sciences and Nutrition, Journal Year: 2025, Volume and Issue: unknown, P. 1 - 11

Published: March 2, 2025

Seaweed-derived dietary fibre sodium alginate (SA) has been shown to present with health benefits in food-derived disease models. To determine whether SA improves the rather than merely suppressing its progression, we assessed effects using farnesoid X receptor (FXR)-deficient mice provide a model of advanced hyperlipidaemia. Fxr-null were fed 5% SA-supplemented diet for nine weeks and showed significant decreases levels liver triglycerides (p < 0.05), total cholesterol serum low-density lipoprotein-cholesterol 0.001). The expression fatty acid-synthesizing genes (Fas Scd1) cholesterol-metabolizing (Hmgcr, Hmgcs, Abca1), significantly reduced. Furthermore, supplementation altered gut microbiota increased abundance genus Oscillospira 0.001) Parabacteroides 0.01). These results suggest that lipid disruption influences composition mice.

Language: Английский

Citations

Exploring the potential of Fucoidan from Laminaria japonica: A comprehensive review of its biological activities and benefits for human DOI