Özgür Yayınları eBooks,
Journal Year:
2023,
Volume and Issue:
unknown
Published: June 25, 2023
Genetic
engineering
and
biotechnology
intersect
in
many
ways.
Both
have
been
used,
albeit
unknowingly,
since
ancient
times.
For
example,
between
8000-1000
BCE,
animals
such
as
horses,
camels,
various
crops
like
maize
wheat
were
domesticated
by
the
people
of
that
era.
After
domestication,
they
started
crossbreeding
for
better
yields.
instance,
crossed
a
cow
with
high
milk
yield
strength
to
obtain
cows
produced
more
stronger.
Similarly,
crossing
high-yielding
drought-resistant
wheat,
obtained
productive
could
withstand
drought.
Not
only
Romans
or
Greeks
but
also
Indians
began
conducting
similar
experiments.
As
result
these
studies,
concept
genetics
emerged
1st
century
CE.
In
19th
century,
Mendel
made
significant
contributions,
firmly
establishing
concepts
genes
genetics.
From
present,
numerous
studies
conducted
develop
genetic
biotechnology,
shaping
them
into
what
are
today.
revolutionized
aspects
scientific
research,
agriculture,
medicine,
industry.
This
field
encompasses
manipulation
material
alter
characteristics
organisms
create
new
biological
entities.
this
paper,
we
provide
general
overview
principles
define
engineering,
focusing
on
its
core
concepts,
techniques,
applications.
BMC Genomics,
Journal Year:
2024,
Volume and Issue:
25(1)
Published: Jan. 2, 2024
Abstract
Background
GRAS
is
a
family
of
plant-specific
transcription
factors
(TFs)
that
play
vital
role
in
plant
growth
and
development
response
to
adversity
stress.
However,
systematic
studies
the
TF
kiwifruit
have
not
been
reported.
Results
In
this
study,
we
used
bioinformatics
approach
identify
eighty-six
AcGRAS
TFs
located
on
twenty-six
chromosomes
phylogenetic
analysis
classified
them
into
ten
subfamilies.
It
was
found
gene
structure
relatively
conserved
for
these
genes
fragmental
duplication
prime
force
evolution
genes.
promoter
region
mainly
contains
cis-acting
elements
related
hormones
environmental
stresses,
similar
results
GO
KEGG
enrichment
analysis,
suggesting
hormone
signaling
pathways
regulating
Protein
interaction
network
showed
AcGRAS51
protein
relational
linking
DELLA,
SCR,
SHR
subfamily
proteins.
The
demonstrated
81
were
expressed
under
salt
stress,
including
17
differentially
genes,
13
upregulated,
four
downregulated.
This
indicates
upregulated
AcGRAS55
,
AcGRAS69
AcGRAS86
other
can
reduce
damage
caused
by
plants
positively
thus
improving
tolerance
plants.
Conclusions
These
provide
theoretical
basis
future
exploration
characteristics
functions
more
study
provides
further
research
breeding
resistance
RT-qPCR
expression
3
elevated
indicating
exhibited
specific
pattern
stress
conditions.
ACS Omega,
Journal Year:
2023,
Volume and Issue:
8(36), P. 32244 - 32257
Published: Sept. 1, 2023
Mycobacterium
tuberculosis,
the
bacterium
responsible
for
is
a
global
health
concern,
affecting
millions
worldwide.
This
has
earned
reputation
as
formidable
adversary
due
to
its
multidrug-resistant
nature,
allowing
it
withstand
many
antibiotics.
The
development
of
this
drug
resistance
in
tuberculosis
attributed
innate
and
acquired
mechanisms.
In
past,
rifampin
was
considered
potent
medication
treating
infections.
However,
rapid
by
underscores
pressing
need
new
therapeutic
agents.
Fortunately,
several
other
medications
previously
overlooked
treatment
are
already
available
market.
Moreover,
innovative
drugs
under
clinical
investigation,
offering
hope
more
effective
treatments.
To
enhance
effectiveness
these
drugs,
recommended
that
researchers
concentrate
on
identifying
unique
target
sites
within
during
process.
strategy
could
potentially
circumvent
issues
presented
resistance.
review
primarily
focuses
characteristics
novel
mechanisms
tuberculosis.
It
also
discusses
potential
being
repositioned
or
sourced
from
origins.
ultimate
objective
discover
efficacious
treatments
can
successfully
tackle
hurdles
posed
Plants,
Journal Year:
2023,
Volume and Issue:
12(23), P. 3961 - 3961
Published: Nov. 24, 2023
Phytophagous
insects
pose
a
significant
threat
to
global
crop
yield
and
food
security.
The
need
for
increased
agricultural
output
while
reducing
dependence
on
harmful
synthetic
insecticides
necessitates
the
implementation
of
innovative
methods.
utilization
CRISPR-Cas
(Clustered
regularly
interspaced
short
palindromic
repeats)
technology
develop
insect
pest-resistant
plants
is
believed
be
highly
effective
approach
in
production
expenses
enhancing
profitability
farms.
Insect
genome
research
provides
vital
insights
into
gene
functions,
allowing
better
knowledge
biology,
adaptability,
development
targeted
pest
management
disease
prevention
measures.
editing
technique
has
capability
modify
DNA
insects,
either
trigger
drive
or
overcome
their
resistance
specific
insecticides.
advancements
CRISPR
its
various
applications
have
shown
potential
developing
insect-resistant
varieties
other
strategies
through
sustainable
approach.
This
could
consequences
ensuring
involves
using
create
modified
plants.
article
critically
analyzed
discussed
challenges
associated
with
exploring
utilizing
pressure
