Tumor-associated senescent macrophages, their markers and their role in the tumor microenvironment (review) DOI
Tamara V. Pukhalskaia,

T. R. Yrakova,

Daria A. Bogdanova

et al.

Биохимия, Journal Year: 2024, Volume and Issue: 89(5), P. 818 - 832

Published: Nov. 14, 2024

Tumor-associated macrophages (TAMs) are an important component of the tumor microenvironment (TME) and most abundant population immune cells infiltrating a tumor. TAMs can largely determine direction anti-tumor response. promote it or, conversely, contribute to formation immunosuppressive TME that allows tumors evade control. Through interactions with or other in microenvironment, as result action anti-cancer therapy, enter senescence. In this review, we have attempted summarize information available literature on role senescent tumors. With recent development senolytic therapeutic strategies aimed at removing from organism. It seems discuss functions potential drugs reprogramming enhance response improve efficacy cancer treatment.

Language: Английский

Immunosenescence and macrophages: From basics to therapeutics DOI Open Access
Hongkang Zhu,

Fanglin Shen,

Tingting Liao

et al.

The International Journal of Biochemistry & Cell Biology, Journal Year: 2023, Volume and Issue: 165, P. 106479 - 106479

Published: Oct. 20, 2023

Language: Английский

Citations

13
Tumor-Associated Senescent Macrophages, Their Markers, and Their Role in Tumor Microenvironment DOI
Tamara V. Pukhalskaia,

Taisiya R. Yurakova,

Daria A. Bogdanova

et al.

Biochemistry (Moscow), Journal Year: 2024, Volume and Issue: 89(5), P. 839 - 852

Published: May 1, 2024

Language: Английский

Citations

4
Molecular Signatures of Cellular Senescence in Cancer: A Critical Review of Prognostic Implications and Therapeutic Opportunities DOI

Debora C Santos-Sousa,

Suzan Gonçalves Rosa, Eduardo Cremonese Filippi–Chiela

et al.

Mechanisms of Ageing and Development, Journal Year: 2025, Volume and Issue: unknown, P. 112052 - 112052

Published: March 1, 2025

Language: Английский

Citations

0
Tumor-associated senescent macrophages, their markers and their role in the tumor microenvironment (review) DOI
Tamara V. Pukhalskaia,

T. R. Yrakova,

Daria A. Bogdanova

et al.

Биохимия, Journal Year: 2024, Volume and Issue: 89(5), P. 818 - 832

Published: Nov. 14, 2024

Tumor-associated macrophages (TAMs) are an important component of the tumor microenvironment (TME) and most abundant population immune cells infiltrating a tumor. TAMs can largely determine direction anti-tumor response. promote it or, conversely, contribute to formation immunosuppressive TME that allows tumors evade control. Through interactions with or other in microenvironment, as result action anti-cancer therapy, enter senescence. In this review, we have attempted summarize information available literature on role senescent tumors. With recent development senolytic therapeutic strategies aimed at removing from organism. It seems discuss functions potential drugs reprogramming enhance response improve efficacy cancer treatment.

Language: Английский

Citations

0