Experimental Cell Research, Journal Year: 2024, Volume and Issue: 444(2), P. 114365 - 114365
Published: Dec. 1, 2024
Language: Английский
Functional & Integrative Genomics, Journal Year: 2025, Volume and Issue: 25(1)
Published: Jan. 17, 2025
Language: Английский
Citations
0
Naunyn-Schmiedeberg s Archives of Pharmacology, Journal Year: 2025, Volume and Issue: unknown
Published: Jan. 18, 2025
Abstract Globally, the incidence and death rates associated with cancer persist in rising, despite considerable advancements therapy. Although some malignancies are manageable by a mix of chemotherapy, surgery, radiation, targeted therapy, most malignant tumors either exhibit poor responsiveness to early identification or endure post-treatment survival. The prognosis for prostate (PCa) is unfavorable since it perilous lethal malignancy. capacity phytochemical nutraceutical chemicals repress oncogenic lncRNAs activate tumor suppressor has garnered significant attention as possible strategy diminish development, proliferation, metastasis, invasion cells. A potential technique treat enhance sensitivity cells existing conventional therapies use phytochemicals anticancer characteristics. Functional studies indicate that modulate drug resistance, stemness, invasion, angiogenesis, proliferation via interactions suppressors oncoproteins. Among them, numerous lncRNAs, such HOTAIR, PlncRNA1, GAS5, MEG3, LincRNA-21, POTEF-AS1, support development PCa through many molecular mechanisms, including modulation regulation various signal pathways like PI3K/Akt, Bax/Caspase 3, P53, MAPK cascade, TGF-β1. Other particular, MALAT-1, CCAT2, DANCR, LncRNA-ATB, ZEB1-AS1, SChLAP1, H19, key players regulating aforementioned processes. Natural substances have shown promising benefits against altering essential signaling pathways. overexpression advanced TNM stage, chemoresistance, reduced LncRNAs possess crucial clinical transitional implications PCa, diagnostic prognostic biomarkers, well medicinal targets. To impede progression beneficial target aberrant long non-coding RNAs using antisense oligonucleotides small interfering (siRNAs). This prevents them from transmitting harmful messages. In summary, several precision medicine approaches may be used rectify dysfunctional lncRNA regulatory circuits, so improving detection eventually facilitating conquest this disease. Due their presence biological fluids tissues, they serve novel biomarkers. Enhancing treatments mitigates resistance chemotherapy radiation.
Language: Английский
Citations
0
Functional & Integrative Genomics, Journal Year: 2025, Volume and Issue: 25(1)
Published: Feb. 15, 2025
Colon cancer (CC) is a common malignancy with rising incidence worldwide. Despite advances in treatment strategies, many patients still face poor prognosis due to the development of drug resistance. Long non-coding RNAs (lncRNAs) have emerged as important regulators various biological processes and been implicated progression. Among them, colorectal neoplasia differentially expressed (CRNDE) has drawn attention for its potential roles different cancers. However, specific functions CC remain unclear. In this study, we identified CRNDE highly CC, contributing tumor progression Mechanically, regulated by transcription factor TFAP2A. Additionally, inhibits pyroptosis, form programmed cell death, promoting ubiquitin-mediated degradation RIPK3, thereby reducing sensitivity cells 5-fluorouracil (5-FU). Our findings suggest that TFAP2A/CRNDE/RIPK3 axis plays critical colon chemoresistance, highlighting therapeutic targets improving outcomes.
Language: Английский
Citations
0
Journal of Biochemical and Molecular Toxicology, Journal Year: 2025, Volume and Issue: 39(3)
Published: Feb. 23, 2025
ABSTRACT Gastric cancer (GC) represents a major global health concern, with over 1 million new cases diagnosed annually worldwide. Emerging studies have highlighted the significant correlation between long noncoding RNAs (lncRNAs) and progression of GC. The objective current study is to investigate roles mechanism lncRNA homeobox A10 antisense RNA (HOXA10‐AS) in modulating malignant properties GC cells. RT‐qPCR was employed detect HOXA10‐AS expression cells or human normal gastric epithelium cellular localization mRNA HOXA10 were detected using fractionation assays. Colony forming assays Transwell performed assess proliferative, invasive, migratory capabilities Western blot analysis used determine protein levels epithelial mesenchymal transition (EMT) markers immunoprecipitation, pulldown luciferase conducted explore gene interaction. As shown by experimental results, showed high silencing led weakened abilities cells, as well inhibition EMT process. Moreover, positively regulated interacting miR‐29a/b/c‐3p. Additionally, overexpression counteracted repressive impacts on process caused knockdown HOXA10‐AS. Furthermore, activated p38 MAPK/STAT3 signaling pathway via upregulation HOXA10. In conclusion, upregulates through interaction resultant increase activates signaling, thereby promoting cell growth, migration, invasion,
Language: Английский
Citations
0
Functional & Integrative Genomics, Journal Year: 2025, Volume and Issue: 25(1)
Published: Feb. 24, 2025
Language: Английский
Citations
0
Naunyn-Schmiedeberg s Archives of Pharmacology, Journal Year: 2025, Volume and Issue: unknown
Published: April 9, 2025
Language: Английский
Citations
0
Medical Oncology, Journal Year: 2024, Volume and Issue: 41(12)
Published: Oct. 27, 2024
Language: Английский
Citations
3
International Immunopharmacology, Journal Year: 2024, Volume and Issue: 143, P. 113577 - 113577
Published: Nov. 15, 2024
Language: Английский
Citations
3
Experimental Cell Research, Journal Year: 2024, Volume and Issue: 444(2), P. 114365 - 114365
Published: Dec. 1, 2024
Language: Английский
Citations
1