Deciphering of SOX9 Functions in Pancreatic Cancer Cells DOI Open Access
К. Н. Кашкин, L. G. Kondratyeva, E. P. Kopantzev

et al.

International Journal of Molecular Sciences, Journal Year: 2025, Volume and Issue: 26(6), P. 2652 - 2652

Published: March 15, 2025

SOX9 is widely regarded as a key master regulator of gene transcription, responsible for the development and differentiation programs within tissue organogenesis, particularly in pancreas. overexpression has been observed multiple tumor types, including pancreatic cancer, discussed prognostic marker. In order to gain more profound understanding role we have performed knockdown COLO357 PANC-1 cells using RNA interference, followed by full-transcriptome analysis siRNA-transfected cells. The molecular pathway enrichment between SOX9-specific control reveals activation processes associated with cellular signaling, cell differentiation, methylation, alongside suppression genes involved various stages cycle apoptosis, upon knockdown. Alterations expression transcription factors, epithelial–mesenchymal transition markers, oncogenes, suppressor genes, drug resistance-related comparison primary metastatic cancer are discovered. levels comprising signatures were also evaluated following Additional studies needed assess properties significance other biological models.

Language: Английский

Deciphering of SOX9 Functions in Pancreatic Cancer Cells DOI Open Access
К. Н. Кашкин, L. G. Kondratyeva, E. P. Kopantzev

et al.

International Journal of Molecular Sciences, Journal Year: 2025, Volume and Issue: 26(6), P. 2652 - 2652

Published: March 15, 2025

SOX9 is widely regarded as a key master regulator of gene transcription, responsible for the development and differentiation programs within tissue organogenesis, particularly in pancreas. overexpression has been observed multiple tumor types, including pancreatic cancer, discussed prognostic marker. In order to gain more profound understanding role we have performed knockdown COLO357 PANC-1 cells using RNA interference, followed by full-transcriptome analysis siRNA-transfected cells. The molecular pathway enrichment between SOX9-specific control reveals activation processes associated with cellular signaling, cell differentiation, methylation, alongside suppression genes involved various stages cycle apoptosis, upon knockdown. Alterations expression transcription factors, epithelial–mesenchymal transition markers, oncogenes, suppressor genes, drug resistance-related comparison primary metastatic cancer are discovered. levels comprising signatures were also evaluated following Additional studies needed assess properties significance other biological models.

Language: Английский

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