Long COVID in healthcare workers: longitudinal mixed-methods study DOI Creative Commons
Aileen Grant,

N N Adams,

Emma MacIver

et al.

Occupational Medicine, Journal Year: 2024, Volume and Issue: unknown

Published: Nov. 29, 2024

Abstract Background Healthcare workers (HCWs) report higher rates of long coronavirus disease (COVID) (LC) than other occupational groups. It is still unclear whether LC a lifelong condition. Workforce shortfalls are apparent due to sick leave, reduced hours and lower productivity. Aims To investigate the lived experience on range HCWs, including impact health-related quality-of-life (HRQL), use health services, working personal lives household finances. Methods Longitudinal mixed methods with online surveys qualitative interviews 6-months apart. HCWs healthcare professionals, ancillary administration staff who self-report were recruited through social media National Health Service channels. Interviewees purposively sampled from survey responses. Results The first was completed by 471 (S1) 302 (64%) follow-up (S2). A total 50 interviewed initially 44 at second interview. All participants experienced various relapsing, remitting, changing prolonged symptoms (mean 7.1 [SD 4.8] S2) third reported day-to-day activities ‘limited lot’. Most in capacity: hours, different role or location. limited, often unsatisfactory. Participants feared reinfection, their future, ability work financial security (59% (n = 174) S2). They stigma, distress, grief for former self some felt unsupported, however, as awareness grew improved understanding support. Conclusions continued working, managing complex dynamic effecting everyday life work. did not significant improvements over time future security.

Language: Английский

Long COVID science, research and policy DOI Creative Commons
Ziyad Al‐Aly, Hannah Davis, Lisa McCorkell

et al.

Nature Medicine, Journal Year: 2024, Volume and Issue: 30(8), P. 2148 - 2164

Published: Aug. 1, 2024

Long COVID represents the constellation of post-acute and long-term health effects caused by SARS-CoV-2 infection; it is a complex, multisystem disorder that can affect nearly every organ system be severely disabling. The cumulative global incidence long around 400 million individuals, which estimated to have an annual economic impact approximately $1 trillion-equivalent about 1% economy. Several mechanistic pathways are implicated in COVID, including viral persistence, immune dysregulation, mitochondrial dysfunction, complement endothelial inflammation microbiome dysbiosis. devastating impacts on individual lives and, due its complexity prevalence, also has major ramifications for systems economies, even threatening progress toward achieving Sustainable Development Goals. Addressing challenge requires ambitious coordinated-but so far absent-global research policy response strategy. In this interdisciplinary review, we provide synthesis state scientific evidence assess human health, systems, economy metrics, forward-looking roadmap.

Language: Английский

Citations

101
COVID-19 Transmission During the Winter 2023-24 Surge: A Comparative Analysis of Surveillance Estimates in the U.S., Canada, and the U.K. DOI Creative Commons
Michael Hoerger, James Gerhart,

Tristen Peyser

et al.

Research Square (Research Square), Journal Year: 2025, Volume and Issue: unknown

Published: Jan. 9, 2025

Abstract Background: Better estimates of COVID-19 transmission are needed since testing has declined. The present investigation examined the correspondence among during winter 2023-24 surge using wastewater-derived for U.S. and Canada testing-derived estimate in U.K. to evaluate validity provide vital public health data on levels. Methods: study used from (Pandemic Mitigation Collaborative dashboard) (COVID-19 Resources testing-based surveillance (Health Security Agency). Data sets were linked by date relative peak within each set. Analyses focused UKHSA period November 2023 March 2024. 1) described day, 2) agreement patterns via correlations, 3) absolute proportion population actively infectious across two months transmission, 4) populations infected months. Results: On day infections, an estimated 1.95 million people U.S., 148 thousand Canada, 431 U.K., meaning 2.5%-4.5% these infectious. Estimates showed high throughout wave, especially between (r=.974, p<.001). During 93.5% 68.8% had excellent or better with data. An >100 months, 20.9%-26.0% population. Discussion: Findings support ongoing significance documenting levels surge. Transmission methodologies nations. More resources prevent diagnose treat long-term sequelae.

Language: Английский

Citations

1
Cost-effectiveness models assessing COVID-19 booster vaccines across eight countries: A review of methods and data inputs DOI

Darvin Scott Smith,

Maarten J. Postma, David N. Fisman

et al.

Vaccine, Journal Year: 2025, Volume and Issue: 51, P. 126879 - 126879

Published: Feb. 15, 2025

Language: Английский

Citations

1
Plasma exchange therapy for the post COVID-19 condition: a phase II, double-blind, placebo-controlled, randomized trial DOI Creative Commons
Sergio España-Cueto, Cora Loste,

Gemma Lladós

et al.

Nature Communications, Journal Year: 2025, Volume and Issue: 16(1)

Published: Feb. 24, 2025

Language: Английский

Citations

1
Health-Related Quality of Life in Long COVID: Mapping the Condition-Specific C19-YRSm Measure Onto the EQ-5D-5L DOI Creative Commons
Adam B. Smith, Darren C. Greenwood, Paul Williams

et al.

Patient Related Outcome Measures, Journal Year: 2025, Volume and Issue: Volume 16, P. 55 - 66

Published: Jan. 1, 2025

Long COVID (LC) is a clinical syndrome with persistent, fluctuating symptoms subsequent to COVID-19 infection. LC has significant detrimental effects on health-related quality of life (HRQoL), activities daily living (ADL), and work productivity. Condition-specific patient-reported outcome measures (PROMs), such as the modified Yorkshire Rehabilitation Scale (C19-YRSm) do not provide health utility data required for cost-utility analyses interventions. The aim this study was derive mapping algorithm C19-YRSm enable utilities be generated from PROM. Data were collected large evaluating services in UK. A total 1434 people had completed both EQ-5D. Correlation linear regression applied determine items covariates inclusion algorithm. Model fit, mean differences across range EQ-5D-3L scores, Bland-Altman plots evaluated. Responsiveness (standardised response mean; SRM) mapped investigated subset participants repeat assessments. There strong level association between 8 one domain EQ-5D single-item dimensions. fit good (R2 = 0.7). difference observed scores <0.10 0 1 indicating targeting positive values EQ-5D-3L. SRM 0.37 compared 0.17 suggesting more responsive change. simple, responsive, robust developed generate C19-YRSm. This will facilitate economic evaluations interventions, treatment, management, well further helping describe characterise patients irrespective any treatment

Language: Английский

Citations

0
We must recognise the collective wisdom of those with lived experience of long covid DOI Open Access
Fiona Jones, Monica Busse,

C Rowe

et al.

BMJ, Journal Year: 2025, Volume and Issue: unknown, P. r243 - r243

Published: Feb. 4, 2025

Language: Английский

Citations

0
Analysis of risk factors for long COVID after mild COVID-19 during the Omicron wave in Japan DOI

Hotaka Namie,

Takahiro Takazono,

Rina Kawasaki

et al.

Respiratory Investigation, Journal Year: 2025, Volume and Issue: 63(3), P. 303 - 310

Published: March 5, 2025

Language: Английский

Citations

0
An international comparison of longitudinal health data collected on long COVID in nine high income countries: a qualitative data analysis DOI Creative Commons
Josephine Exley, Edmund Stubbs, Raphael Wittenberg

et al.

Health Research Policy and Systems, Journal Year: 2025, Volume and Issue: 23(1)

Published: March 24, 2025

Abstract Background Long coronavirus disease (COVID) presents a significant health challenge. Long-term monitoring is critical to support understanding of the condition, service planning and evaluation. We sought identify examine longitudinal data collected on long COVID inform potential decisions in England regarding rationale for collection, collected, sources from which were methods used collection. Methods included datasets high-income countries that experienced similar 2019 (COVID-19) waves pre-vaccine rollout. Relevant identified through literature searches, authors’ networks participants’ recommendations. undertook semi-structured interviews with individuals involved development running datasets. held focus group discussion representatives three patient organisations capture perspective those COVID. Emergent findings tested workshop country interviewees. Results analysed 17 nine (Belgium, Canada, Germany, Italy, Netherlands, New Zealand, Sweden, Switzerland United Kingdom). Datasets sampled different populations, collection tools measured outcomes, reflecting priorities. Most was research (rather than care system)-funded time-limited. For linked specialist services, there uncertainty surrounding how these would continue. Definitions varied. Patient representatives’ favoured self-identification, given challenges accessing receiving diagnosis; Zealand’s registry only example using this approach. Post-exertion malaise, by patients as outcome, absent all The lack patient-reported outcome measures (PROMs) highlighted limitation reliant routine data, although some had developed mechanisms extend surveys. Conclusions Addressing questions related management requires diverse populations over long-term. No examined has comprehensive long-term system COVID, and, many settings, ending leaving gap. There no obvious model or other follow, assuming remains sufficient policy interest establishing registry.

Language: Английский

Citations

0
Guidelines for a sustainable return to work with long COVID DOI
Clare Rayner, Kim Burton, Ewan B Macdonald

et al.

Occupational Medicine, Journal Year: 2025, Volume and Issue: 75(1), P. 9 - 13

Published: Jan. 1, 2025

Long coronavirus disease (COVID) is an umbrella term to describe prolonged health problems and symptoms that arise following COVID infection. It affecting a large proportion of the working population high rates long-term work absence, detrimental individuals, employers economies. Return (RTW) often difficult incomplete. The Society Occupational Medicine has produced detailed guidelines try achieve sustained RTW, aimed at managers, employers, occupational professionals workers.

Language: Английский

Citations

0
How vulnerable employment and public health quality shape labour productivity: A comparative study of European economies DOI Creative Commons
Serhiy Lyeonov, Наталія Шелєміна,

Zuzanna Szpakowska

et al.

JOURNAL OF INTERNATIONAL STUDIES, Journal Year: 2025, Volume and Issue: 18(1), P. 232 - 253

Published: March 1, 2025

The relationship between health indicators and labour productivity has been gaining increasing importance as European economies have come to navigate ageing populations, health-related absenteeism, evolving employment structures. This study investigates how vulnerable employment, Disability-Adjusted Life Years (DALYs) affect GDP per person employed across 21 countries from 2000 2021. Employing a robust methodological framework – including Two-Way Fixed Effects, Feasible Generalized Least Squares, Linear Mixed Models the analysis accounted for heteroscedasticity, unobserved heterogeneity, panel structure of data. Model was identified most reliable interpreting outcomes based on model comparison criteria. findings indicate that 1% increase in absenteeism is associated with 0.064% decrease employed. DALYs among older workers (aged 50–69) reduce by 0.657% increase, while younger 15–49) show marginally positive effect 0.132%. Vulnerable impact 0.089% increase. In contrast, rise share wage salaried contributes 2.383% productivity. These underscore strengthening systems workers, reducing vulnerability, promoting stable, formal job opportunities support long-term economic performance.

Language: Английский

Citations

0