Neurologic manifestations of Long COVID in Colombia: a comparative analysis of post-hospitalization vs. non-hospitalized patients

Frontiers in Human Neuroscience, Journal Year: 2024, Volume and Issue: 18

Published: Aug. 13, 2024

Objective To analyze patient-reported outcomes, cognitive function, and persistent symptoms in patients with neurologic post-acute sequelae of SARS-CoV-2 infection (Neuro-PASC) Colombia. Methods We recruited laboratory-confirmed COVID-19 PASC lasting more than 6 weeks at the CES University Clinic (Medellín, Colombia). included 50 post-hospitalization Neuro-PASC (PNP) non-hospitalized (NNP) patients. Long-COVID symptoms, (NIH Toolbox v2.1-Spanish for 18+), (PROMIS) relevant medical history were evaluated. Statistical analyses performed via generalized linear models. Results Overall, brain fog (60%), myalgia (42%), numbness or tingling (41%) most common neurological while fatigue (74%), sleep problems (46%), anxiety (44%) non-neurological symptoms. Compared to NNP, PNP showed a higher frequency abnormal exam findings (64% vs. 42%, p = 0.028). Both groups had impaired quality life (QoL) domains cognition, fatigue, depression disturbance, worse on processing speed attention normative population. In addition, NNP executive function (T-score 42.6 48.5, 0.012). associated QoL outcomes. Brain remained across all durations Long COVID. Conclusion Our highlight high incidence heterogeneity impacts COVID even 2 years from disease onset. Early detection, emotional support targeted management are warranted.

Language: Английский

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Vocational rehabilitation for Long Covid: a roadmap for recovery

Occupational Medicine, Journal Year: 2024, Volume and Issue: 74(4), P. 262 - 265

Published: May 1, 2024

Long Covid continues to impact many people’s workability; some have lived with it for years, experiencing return-to-work attempts followed by redeployment, contractual changes—even capability proceedings. For those in low-paid work or self-employment, financial insecurity, retention options are likely be reduced even further. New cases of continue, and the need support workers earlier their trajectory return as a key outcome remains crucial. Support people has been lacking date; here we introduce practical tool that can utilized rehabilitation occupational health professionals alike.

Language: Английский

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Public Health and Economic Impact of Periodic COVID-19 Vaccination with BNT162b2 for Old Adults and High-Risk Patients in an Illustrative Prefecture of Japan: A Budget Impact Analysis

Infectious Diseases and Therapy, Journal Year: 2024, Volume and Issue: 13(10), P. 2155 - 2177

Published: Sept. 10, 2024

Japan will be transitioning from the free-of-charge COVID-19 vaccination program to annual periodic under a national immunization for old adults and high-risk patients 2024 fall/winter season. The policy transition including out-of-pocket payment requirement may discourage vaccination, leading lower rate. This study aimed estimate impact of varying rates with BNT162b2 mRNA vaccine on economics public health in an illustrative prefecture which administers promotes program, using budget analysis.

Language: Английский

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Trajectories of functional limitations, health-related quality of life and societal costs in individuals with long COVID: a population-based longitudinal cohort study

BMJ Open, Journal Year: 2024, Volume and Issue: 14(11), P. e088538 - e088538

Published: Nov. 1, 2024

Objectives To examine trajectories of functional limitations, fatigue, health-related quality life (HRQL) and societal costs patients referred to long COVID clinics. Design A population-based longitudinal cohort study using real-time user data. Setting 35 specialised clinics in the UK. Participants 4087 adults diagnosed with primary or secondary care deemed suitable for rehabilitation registered Living With Covid Recovery (LWCR) programme between 4 August 2020 5 2022. Main outcome measures Generalised linear mixed models were fitted estimate Work Social Adjustment Scale (WSAS); scores ≥20 indicate moderately severe limitations. Other outcomes included fatigue Functional Assessment Chronic Illness Therapy–Fatigue (FACIT-F) reversed score (scores ≥22 impairment), HRQL EQ-5D-5L, COVID-related costs, encompassing healthcare productivity losses. Results The mean WSAS at 6 months after registration LWCR was 19.1 (95% CI 18.6, 19.6), 46% participants 40.3%, 52.4%) reporting a above 20 (moderately worse impairment). change over 6-month period −0.86 −1.32, –0.41). FACIT-F 29.1 22.7, 35.5) compared 32.0 31.7, 32.3) baseline. EQ-5D-5L remained relatively constant baseline (0.63, 95% 0.62, 0.64) (0.64, 0.59, 0.69). monthly cost per patient related £931, mostly driven by associated working days lost. Conclusions Individuals UK reported small improvements ability work within registering programme.

Language: Английский

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Exploring social determinants of health and their impacts on self-reported quality of life in long COVID-19 patients

Scientific Reports, Journal Year: 2024, Volume and Issue: 14(1)

Published: Dec. 6, 2024

This study explores the health-related quality of life (HRQoL) experienced by patients with Long COVD-19 using data from British Columbia's post-COVID-19 Recovery Clinics. A retrospective cohort 3463 was analyzed to assess HRQoL through EQ-5D-5L questionnaire which includes five dimensions (mobility, self-care, usual activities, physical health, and mental health) administered patients; responses were Visual Analogue Score (VAS). Notably, 95% participants reported scores below 90, 50% scoring under 60, indicating significant impacts on their well-being. The analysis revealed that is significantly influenced various social determinants health (SDoH), including age, sex, employment status, ethnicity, each showing distinct correlations overall VAS scores. Specifically, older age associated decreased mobility increased pain/discomfort but less anxiety depression, highlighting varying across spectrum. highlights multifaceted COVID lives underscores necessity targeted strategies improve among diverse groups, considering specific SDoH. Such a comprehensive approach could lead more equitable outcomes support development tailored public policies aimed at recovery rehabilitation sufferers.

Language: Английский

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The relationship between long COVID, labor productivity, and socioeconomic losses in Japan: A cohort study

IJID Regions, Journal Year: 2024, Volume and Issue: 14, P. 100495 - 100495

Published: Nov. 20, 2024

We examined shifts in labor productivity and their economic ramifications among adult patients with long COVID Japan.

Language: Английский

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Health-related quality of life in Long COVID: Mapping the condition-specific C19-YRSm measure onto the EQ-5D-5L

medRxiv (Cold Spring Harbor Laboratory), Journal Year: 2024, Volume and Issue: unknown

Published: Aug. 11, 2024

Abstract Background Long Covid (LC) is a clinical syndrome of persistent, fluctuating symptoms subsequent to COVID-19 infection with prevalence global estimate many millions cases. LC has significant detrimental effects on health-related quality life (HRQoL), activities daily living (ADL), and work productivity. Condition-specific patient-reported outcome measures (PROMs), such as the modified Covid-19 Yorkshire Rehabilitation Scale (C19-YRSm), have been developed capture impact LC. However, these do not provide health utility data required for cost-utility analyses interventions. The aim this study was therefore derive mapping algorithm C19-YRSm enable utilities be generated from PROM. Methods Data were collected large evaluating services in UK. A total 1434 people had completed both EQ-5D-5L same day. responses then converted EQ-5D-3L scores. Correlation linear regression applied determine items covariates inclusion algorithm. Model fit, mean differences across range scores (−0.59 1), Bland-Altman plots used evaluate Responsiveness (standardised response mean; SRM) mapped also investigated subset participants repeat assessments (N=85). Results There strong level association between 8 2 domains EQ-5D single-item dimensions. These related joint pain, muscle anxiety, depression, walking/moving around, personal care, ADL, social role, well Overall Health Other Symptoms. fit good (R = 0.7). difference actual < 0.10 0 1 indicating degree targeting positive values EQ-5D-3L. SRM (based C19-YRSm) 0.37 compared 0.17 observed scores, suggesting more responsive change. Conclusions We simple, responsive, robust 10 C19-YRSm. This will facilitate economic evaluations interventions, treatment, management LC, further helping describe characterise patients irrespective any treatment

Language: Английский

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An ecological comparison to inspect the aftermath of post COVID-19 condition in Italy and the United States

Scientific Reports, Journal Year: 2024, Volume and Issue: 14(1)

Published: Aug. 21, 2024

Post COVID-19 Condition (PCC) is a clinical syndrome following disease. PCC symptoms in adults entail significant productivity loss and reduced quality of life. This study aimed at estimating the epidemiological economic burden among working-age population Italy US. ecological analysis was conducted on data from January 2020 to April 2023, regarding aged 18–64. incidence for US retrieved publicly reported estimates, while it estimated cases. Prevalence factors associated with parameters calculate temporary losses (TPL) were retrieved. An rate ratio (eIRR) calculated. TPL earnings total quality-adjusted life years (QALYs) lost also estimated. The eIRR Italy/US 0.842 [95%CI 0.672–1.015], suggesting that, holding cases constant, 15.8% fewer have occurred compared Overall found be 12.0 9.9–14.1] million US, 1.9 1.6–2.3] QALYs lost, 2.4 1.8–3.0] Italy, 0.4 0.3–0.5] lost. Up Int$7.5 5.8–10.1] billion $41.5 34.3–48.7] has had impact population. findings this may use health planning policy adults.

Language: Английский

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Prevalence of COVID‐19 and Long COVID by industry and occupation: Behavioral Risk Factor Surveillance System 2022

American Journal of Industrial Medicine, Journal Year: 2024, Volume and Issue: unknown

Published: Oct. 11, 2024

Abstract Background Workers in healthcare and other essential occupations had elevated risks for COVID‐19 infection early the pandemic. No survey of U.S. workers to date has comprehensively assessed prevalence both Long COVID across industries (I&O) at a detailed level. Methods Behavioral Risk Factor Surveillance System data 2022 from 39 states, Guam, Virgin Islands were used estimate self‐reported history COVID, as well among those reporting prior COVID‐19, by broad I&O. Adjusted ratios compare outcome each I&O all combined. Results By I&O, healthcare, protective services, education prevalences COVID‐19. The was service but not workers. Detailed with significantly included Dairy Product Manufacturing industry subsets mining Both bartenders/drinking places personal care appearance farmworkers who reported having Conclusions Industries levels or this study may warrant increased measures prevent transmission airborne respiratory viruses. Accommodations are key component supporting workplaces. This new information about distribution suggests where employer understanding implementation tailored workplace supports accommodations most needed support continued employment affected

Language: Английский

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Functional disabilities and adverse well‐being by COVID‐19 and Long COVID history and employment status: 2022 Behavioral Risk Factor Surveillance System

American Journal of Industrial Medicine, Journal Year: 2024, Volume and Issue: unknown

Published: Oct. 25, 2024

Abstract Background Long COVID can lead to functional disabilities and decreased well‐being limit the ability work. No study has yet assessed associations of SARS‐CoV‐2‐infection with specific measures among workers by employment status. Methods Using data from U.S. Behavioral Risk Factor Surveillance System, we prevalence adults prime working age (25–54 years) status self‐reported COVID‐19 history. Within each status, generated adjusted ratios (aPRs) comparing respondents 2022 COVID‐19/Long category in that before pandemic (2019). Results In 2022, prevalences disability except vision all adverse were highest 9.2% reporting a history COVID. For outcome, lowest for those unable cognitive (16.4% employees, 21.4% self‐employed) depression (31.2% 36.4%, respectively) more than double 2019 levels. Increases lower but statistically significant not Conclusions The high have implications employers. Also concerning are smaller increases COVID, given large number affected workers. Mitigating effects on will involve efforts multiple domains: reducing incidence, increasing healthcare practitioner awareness, improving diagnosis treatments, employer awareness best practices accommodating

Language: Английский

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