Stress landscape of folding brain serves as a map for axonal pathfinding

Nature Communications, Journal Year: 2025, Volume and Issue: 16(1)

Published: Jan. 30, 2025

Abstract Understanding the mechanics linking cortical folding and brain connectivity is crucial for both healthy abnormal development. Despite importance of this relationship, existing models fail to explain how growing axon bundles navigate stress field within a or bidirectional dynamic interaction shapes resulting surface morphologies patterns. Here, we propose concept “axon reorientation” formulate mechanical model uncover multiscale linkages between Simulations incorporating bundle reorientation stress-induced growth reveal potential mechanisms that lead higher density in gyri (ridges) compared sulci (valleys). In particular, patterning from exhibits strong dependence on rate properties navigating bundles. Model predictions are supported by vivo diffusion tensor imaging human brain.

Language: Английский

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The multiscale mechanics of axon durotaxis

Journal of the Mechanics and Physics of Solids, Journal Year: 2025, Volume and Issue: unknown, P. 106134 - 106134

Published: April 1, 2025

Language: Английский

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Biochemical Pathways of Cellular Mechanosensing/Mechanotransduction and Their Role in Neurodegenerative Diseases Pathogenesis

Cells, Journal Year: 2022, Volume and Issue: 11(19), P. 3093 - 3093

Published: Oct. 1, 2022

In this review, we shed light on recent advances regarding the characterization of biochemical pathways cellular mechanosensing and mechanotransduction with particular attention to their role in neurodegenerative disease pathogenesis. While mechanistic components these are mostly uncovered today, crosstalk between mechanical forces soluble intracellular signaling is still not fully elucidated. Here, recapitulate general concepts mechanobiology mechanisms that govern processes, examine stimuli response, highlighting effect organelles' homeostasis dysfunction. particular, discuss current knowledge about translation mechanosignaling into signaling, focusing those diseases encompass metabolic accumulation mutant proteins have as primary characteristics formation pathological aggregates, such Alzheimer's Disease, Huntington's Amyotrophic Lateral Sclerosis Parkinson's Disease. Overall, findings elucidate how may be crucial understand pathogenic underlying emphasize importance for identifying potential therapeutic targets.

Language: Английский

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Nonlinear dynamics of a three-dimensional discrete-time delay neural network

International Journal of Biomathematics, Journal Year: 2023, Volume and Issue: 17(06)

Published: July 20, 2023

This paper examines a three-dimensional delayed discrete neural network model analytically and numerically to determine the existence of different types bifurcations involved fixed points. The exhibits such as pitchforks, flips, Neimark–Sackers, flip-Neimark–Sackers. critical coefficients are used structure each bifurcation. curves calculated plotted for bifurcation when parameters changed. Further, these theoretically analyzed verified. From obtained results, we observed that by drawing associated with bifurcation, numerical simulations consistent analytical results.

Language: Английский

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Bisphenol S impairs mitochondrial function by targeting Myo19/oxidative phosphorylation pathway contributing to axonal and dendritic injury

Environment International, Journal Year: 2024, Volume and Issue: 186, P. 108643 - 108643

Published: April 1, 2024

Exposure to bisphenol S (BPS) is known adversely affect neuronal development. As pivotal components of polarization, axons and dendrites are indispensable structures within neurons, crucial for the maintenance nervous system function. Here, we investigated impact BPS exposure on axonal dendritic development both in vivo vitro. Our results revealed that during pregnancy lactation led a reduction complexity, density, length prefrontal cortex (PFC) offspring. Employing RNA sequencing technology elucidate underlying mechanisms damage induced by BPS, Kyoto Encyclopedia Genes Genomes (KEGG) analysis highlighted significant alteration oxidative phosphorylation (OXPHOS) pathway, essential mitochondrial Subsequent experiments demonstrate BPS-induced impairment function, including damaged morphology, decreased adenosine triphosphate (ATP) superoxide dismutase (SOD) levels, increased reactive oxygen species malondialdehyde (MDA). These alterations coincided with downregulated expression OXPHOS pathway-related genes (ATP6V1B1, ATP5K, NDUFC1, NDUFC2, NDUFA3, COX6B1) Myosin 19 (Myo19). Notably, Myo19 overexpression restored dysfunction alleviating inhibition pathway. Consequently, this amelioration was associated injury observed cultured neurons PFC.

Language: Английский

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Axonal tension contributes to consistent fold placement

Soft Matter, Journal Year: 2024, Volume and Issue: 20(14), P. 3053 - 3065

Published: Jan. 1, 2024

We propose a novel bilayer finite element model incorporating axonal tension in the subcortex. Our results reveal that serves as perturbation triggers folding and determines placement of folds.

Language: Английский

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Chemical and mechanical control of axon fasciculation and defasciculation

Seminars in Cell and Developmental Biology, Journal Year: 2022, Volume and Issue: 140, P. 72 - 81

Published: July 7, 2022

Language: Английский

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Mimic the electric activity in a heat-sensitive membrane in circuit

AEU - International Journal of Electronics and Communications, Journal Year: 2023, Volume and Issue: 174, P. 155069 - 155069

Published: Dec. 16, 2023

Language: Английский

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The role of mechanics in axonal stability and development

Seminars in Cell and Developmental Biology, Journal Year: 2022, Volume and Issue: 140, P. 22 - 34

Published: July 1, 2022

Language: Английский

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Nonlinear Growth Dynamics of Neuronal Cells Cultured on Directional Surfaces

Biomimetics, Journal Year: 2024, Volume and Issue: 9(4), P. 203 - 203

Published: March 28, 2024

During the development of nervous system, neuronal cells extend axons and dendrites that form complex networks, which are essential for transmitting processing information. Understanding physical processes underlie formation networks is gaining a deeper insight into higher-order brain functions such as sensory processing, learning, memory. In process creating travel towards other recipient neurons, directed by combination internal external cues include genetic instructions, biochemical signals, well mechanical geometrical stimuli. Although there have been significant recent advances, basic principles governing axonal growth, collective dynamics, remain poorly understood. this paper, we present detailed analysis nonlinear dynamics growth on surfaces with periodic patterns. We show these described Langevin equations speed-dependent deterministic terms gaussian stochastic noise. This theoretical model yields comprehensive description at both intermediate long time scales (tens hours after cell plating), predicts key dynamical parameters, speed angular correlation functions, mean squared lengths, diffusion (cell motility) coefficients. use to perform simulations trajectories surfaces, in turn demonstrating very good agreement between simulated experimental results. These results provide important insights current understanding behavior self-wiring designing innovative biomimetic neural network models.

Language: Английский

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