Molecular Mimicry Impact of the COVID-19 Pandemic: Sequence Homology Between SARS-CoV-2 and Autoimmune Diseases Epitopes
ImmunoInformatics,
Journal Year:
2025,
Volume and Issue:
unknown, P. 100050 - 100050
Published: March 1, 2025
Molecular
mimicry
is
one
mechanism
by
which
an
infectious
agent
may
trigger
autoimmune
disease
in
a
human
subject
and
occurs
when
foreign-
self-peptides
contain
similar
epitopes
that
activate
response
susceptible
individual.
Here,
we
employ
scalable
in-silico
approach,
to
identify
861
pairs
of
known
SARS-CoV-2
epitopes,
out
more
than
billion
possible
pairs.
These
show
1)
sequence
homology
disorder
2)
empirical
binding
data
predict
they
bind
the
same
major
histocompatibility
complex
(MHC)
molecule
3)
exhibit
high
immunogenicity.
Analysis
these
epitope
reveals
association
between
disorders,
such
as
type
1
diabetes,
uveitis,
ankylosing
spondylitis,
infection.
associations
are
consistent
with
those
reported
literature
from
analysis
clinical
records.
Language: Английский
Research Hotspots and Frontiers of Alzheimer’s Disease and Gut Microbiota: A Knowledge Mapping and Text Mining Analysis
Youao Zhang,
No information about this author
Zixuan Jia,
No information about this author
Jieyan Wang
No information about this author
et al.
Molecular Neurobiology,
Journal Year:
2024,
Volume and Issue:
61(11), P. 9369 - 9382
Published: April 18, 2024
Language: Английский
Current status and future directions of nanovaccine for cancer: a bibliometric analysis during 2004-2023
Yuhui Hou,
No information about this author
Yue Li,
No information about this author
Youao Zhang
No information about this author
et al.
Frontiers in Immunology,
Journal Year:
2024,
Volume and Issue:
15
Published: July 29, 2024
Nanovaccine
treatment
is
an
exciting
area
of
research
in
immunology
and
personalized
medicine,
holding
great
promise
for
enhancing
immune
responses
targeting
specific
diseases.
Their
small
size
allows
efficient
uptake
by
cells,
leading
to
robust
activation.
They
can
incorporate
immune-stimulating
molecules
boost
vaccine
efficacy.
Therefore,
nanovaccine
be
target
tumor-specific
antigens,
activating
the
system
against
cancer
cells.
Currently,
there
have
been
ample
evidence
showing
effectiveness
potential
as
a
cancer.
However,
was
rare
bibliometric
analysis
Here
we
performed
visual
published
studies
related
cancer,
providing
trend
future
development
nanovaccine.
Language: Английский
Deciphering the IgG Idiotype Network Through Proteomic Analysis of Potential Targets in SARS‐CoV‐2‐Induced Immune Responses
Immunology,
Journal Year:
2025,
Volume and Issue:
unknown
Published: March 12, 2025
ABSTRACT
The
association
between
COVID‐19
and
autoimmune
diseases
has
gained
increasing
recognition,
yet
the
specific
targets
of
SARS‐CoV‐2‐induced
IgG
are
currently
in
focus
for
several
studies.
This
study
aims
to
explore
proteomic
these
antibodies
their
potential
role
autoimmunity.
We
utilised
a
human
proteome
microarray
encompassing
23
736
unique
proteins,
including
isoform
variants
fragments,
as
catalogued
by
Human
Protein
Atlas.
Serum
samples
were
analysed
from
four
groups:
healthy
controls
(N‐exp
HC),
individuals
vaccinated
with
protein‐based
vaccines
(N‐Cov
Vac)
patients
moderate
or
severe
(COVID‐Mod
COVID‐Sev).
evaluation
revealed
recognise
multiple
proteins.
Key
included
interferon
alpha
(IFN‐α),
tumour
growth
factor
beta
(TGF‐β),
interleukin
1
(IL‐1),
CXCL16,
TGF‐β
receptors,
CD34,
CD47
BCL2.
also
targeted
proteins
genes
overexpressed
various
immune
cells,
such
CD4+
CD8+
T
γδ
B
dendritic
cells
NK
cells.
Reactivity
was
observed
specifically
expressed
organs,
brain,
liver,
lungs
heart.
Targeting
patterns
differed
controls,
some
showing
differential
recognition
versus
cases.
Furthermore,
we
evaluated
protein–protein
interaction
network
(PPIN)
all
minimal
structural
homology
co‐expression
among
almost
no
relation
SARS‐CoV‐2
system
reactome.
results
suggest
that
profile
autoantibodies
is
associated
disease
severity.
In
contrast,
protein‐vaccinated
exhibited
similar
non‐exposed
suggesting
autoreactive
linked
active
infection.
These
findings
reveal
complex
idiotypes
capable
targeting
not
merely
through
simple
cross‐recognition
homologous
highlights
need
further
investigations
determine
whether
they
may
influence
pathophysiology
its
clinical
outcomes.
Language: Английский
The status and hotspot analysis of research on extracellular vesicles and osteoarthritis: a bibliometric analysis
W. Zhang,
No information about this author
Wen Xiang,
No information about this author
Lin Yi
No information about this author
et al.
Frontiers in Pharmacology,
Journal Year:
2025,
Volume and Issue:
16
Published: March 31, 2025
Degenerative
joint
disease,
known
as
osteoarthritis
(OA),
is
characterized
by
pain,
swelling,
and
decreased
mobility.
The
illness
has
a
major
negative
influence
on
patients'
quality
of
life
common
around
the
world,
especially
among
older
people.
Nevertheless,
there
are
insufficient
possibilities
for
early
diagnosis
therapy.
Extracellular
vesicles,
or
EVs,
control
immune
response,
tissue
healing,
cellular
communication.
This
work
offers
bibliometric
representation
areas
focus
correlations
between
extracellular
vesicles
osteoarthritis.
We
searched
in
publications
Web
Science
Core
Collection
(WoSCC)
database.
Bibliometrics,
an
R
package,
CiteSpace
6.1.
R2,
VOSviewer
1.6.17
were
used
to
perform
analyses
concentration
fields,
trends,
relevant
factors.
944
papers
from
59
nations
published;
countries
that
contributed
most
field
China,
USA,
Italy.
Professors
Laura
Enrico
top
contributors.
Sichuan
University,
Istituto
Ortopedico
Galeazzi,
Shanghai
Jiao
Tong
University
three
universities.
International
Journal
Molecular
Sciences
excellent
publication.
Exosome,
expression,
knee
osteoarthritis,
vesicle,
mesenchymal
stem
cell,
inflammation
often
occurring
keywords.
These
results
suggest
interest
future
research
EVs
OA.
trend
suggests
volume
literature
OA
will
continue
rise,
with
more
being
published
future.
study
helps
scholars
understand
current
hotspots
may
inspire
research.
Language: Английский
Research trends in essential thrombocythemia from 2001 to 2024: a bibliometric analysis
Yiming Pan,
No information about this author
Lingyan Chen,
No information about this author
Qun Jiang
No information about this author
et al.
Discover Oncology,
Journal Year:
2025,
Volume and Issue:
16(1)
Published: April 15, 2025
Language: Английский
Relationship between gut microbiota and multiple sclerosis: A comprehensive bibliometric and visual analysis of global research trends and therapeutics
Aishwarya Bhattacharya,
No information about this author
Kushagra Agarwal,
No information about this author
Nirmal Kumar Ganguly
No information about this author
et al.
Next research.,
Journal Year:
2025,
Volume and Issue:
unknown, P. 100441 - 100441
Published: May 1, 2025
Language: Английский
Inhibition of Pyroptosis by Hydroxychloroquine as a Neuroprotective Strategy in Ischemic Stroke
Wenshuo Peng,
No information about this author
Kaiming Guo,
No information about this author
Jian Hu
No information about this author
et al.
eNeuro,
Journal Year:
2024,
Volume and Issue:
12(1), P. ENEURO.0254 - 24.2024
Published: Dec. 18, 2024
Hydroxychloroquine
(HCQ),
a
well-known
antimalarial
and
anti-inflammatory
drug,
has
demonstrated
potential
neuroprotective
effects
in
ischemic
stroke
by
inhibiting
pyroptosis,
programmed
cell
death
associated
with
inflammation.
This
study
investigates
the
impact
of
HCQ
on
pathology
using
both
vivo
vitro
models.
In
vivo,
C57BL/6
mice
subjected
to
middle
cerebral
artery
occlusion
(MCAO)
were
treated
HCQ.
Neurological
deficits,
infarct
volume,
expression
pyroptosis
markers
evaluated.
The
results
that
significantly
improved
motor
function
reduced
volume
MCAO
mouse
model.
vitro,
BV2
microglial
cells
exposed
lipopolysaccharide
(LPS)
oxygen–glucose
deprivation
(OGD)
Western
blot
immunofluorescence
analyses
revealed
effectively
suppressed
GSDMD
NLRP3
These
findings
suggest
mitigates
damage
highlighting
its
as
therapeutic
agent
for
stroke.
provides
novel
insights
into
molecular
mechanisms
which
exerts
effects,
offering
promising
new
avenue
developing
safe,
cost-effective,
widely
applicable
treatments.
modulate
neuroinflammatory
pathways
presents
significant
advancement
therapy,
emphasizing
importance
targeting
management
broader
implications
treating
conditions.
Language: Английский