A pan-cancer analysis indicates long noncoding RNA HAND2-AS1 as a potential prognostic, immunomodulatory and therapeutic biomarker in various cancers including colorectal adenocarcinoma DOI Creative Commons
Pouria Samadi, Mina Shahnazari,

Abolfazl Shekari

et al.

Research Square (Research Square), Journal Year: 2023, Volume and Issue: unknown

Published: Aug. 24, 2023

Abstract The HAND2-AS1 (HAND2 Antisense RNA 1) lncRNA has emerged as a participant in the initiation of various cancer types, underscoring its pivotal involvement both oncological processes and immune responses. To gain deeper insights into functional nuances identify novel avenues for immunotherapy, comprehensive evaluation this gene was undertaken. Long noncoding RNAs (lncRNAs) are rising essential regulators expression contributors to modulation. Here, based on co-expression network analysis construction interacting lncRNA-mRNA genes, we introduce lncRNA, emphasizing key roles tumorigenesis regulation. Our study spans across 33 distinct revealing HAND2-AS1's aberrant patterns, methylation variations, mutational signatures, engagement. Across majority tumors, exhibited propensity down-regulation, remarkably an association with poor survival outcomes. outcomes enrichment analyses strongly suggest engagement tumor progression pathways diverse classifications. Additionally, positive correlation between infiltration levels cells, encompassing not only immunosuppressive entities such tumor-associated macrophages, cancer-associated fibroblasts, Tregs, but also effector cells like NK CD8 + T spanning pan-cancer context. Furthermore, differential appears have downstream consequences pathways, thus implicating it potential regulator types. Finally, employed CRC normal samples carry out clinical validation HAND2-AS1. unveils suppressor, role surveillance. heightened emerges promising candidate prognostic evaluation, therapeutic stratagem, focal point immunotherapeutic interventions.

Language: Английский

Targeting senescence and GATA4 in age-related cardiovascular disease: a comprehensive approach DOI
Mohd Imran, Abdulmalik Saleh Alfawaz Altamimi, Muhammad Afzal

et al.

Biogerontology, Journal Year: 2025, Volume and Issue: 26(1)

Published: Jan. 20, 2025

Language: Английский

Citations

0
Prevention and treatment of peri-implant fibrosis by functionally inhibiting skeletal cells expressing the leptin receptor DOI
Vincentius J. Suhardi, Anastasia Oktarina, Mohammed Hammad

et al.

Nature Biomedical Engineering, Journal Year: 2024, Volume and Issue: 8(10), P. 1285 - 1307

Published: July 31, 2024

Language: Английский

Citations

3
Exosomal non-coding RNAs: Blueprint in colorectal cancer metastasis and therapeutic targets DOI Creative Commons
Bashdar Mahmud Hussen,

Sara Tharwat Abdullah,

Snur Rasool Abdullah

et al.

Non-coding RNA Research, Journal Year: 2023, Volume and Issue: 8(4), P. 615 - 632

Published: Sept. 11, 2023

Colorectal cancer (CRC) is ranked as the world's third-most prevalent cancer, and metastatic CRC considerably increases cancer-related fatalities globally. A number of complex mechanisms that are strictly controlled at molecular level involved in metastasis, which primary reason for death people with CRC. Recently, it has become clear exosomes, small extracellular vesicles released by non-tumorous tumorigenic cells, play a critical role communication mediators among tumor microenvironment (TME). To facilitate between TME non-coding RNAs (ncRNAs) crucial recognized potent regulators gene expression cellular processes, such metastasis drug resistance. NcRNAs now many hallmarks including metastasis. Exosomal ncRNAs, like miRNAs, circRNAs, lncRNAs, have been demonstrated to influence contribute However, link exosomal ncRNAs not well understood. This review highlights essential roles progression disease explores therapeutic choices open patients who metastases. ncRNA treatment strategy development still its early phases; consequently, additional investigation required improve delivery methods find novel targets confirm effectiveness safety these therapies preclinical clinical contexts.

Language: Английский

Citations

7
Role of long non-coding RNAs and TGF-β signaling in the regulation of breast cancer pathogenesis and therapeutic targets DOI Creative Commons
Bashdar Mahmud Hussen,

Hazha Jamal Hidayat,

Snur Rasool Abdullah

et al.

Cytokine, Journal Year: 2023, Volume and Issue: 170, P. 156351 - 156351

Published: Aug. 30, 2023

The cytokine known as transforming growth factor (TGF) is essential for cell development, differentiation, and apoptosis in BC. TGF-β dysregulation can either promote or inhibit tumor it a key signaling pathway BC spread. A recently identified family of ncRNAs lncRNAs has received great deal effort an important regulator many cellular processes, including transcription genes, chromatin remodeling, progression the cycle, posttranscriptional processing. Furthermore, both serve early-stage biomarkers diagnosis prognosis also play significant role drug resistance. According to recent studies, regulate by modulating its cofactors However, particular functions controlling are not well understood yet. This review explores lncRNAs' functional properties suppressors oncogenes regulation with focus on dysregulated signaling. Further, we emphasize roles discover new treatment strategies better comprehend fundamental pathways.

Language: Английский

Citations

6
A pan-cancer analysis indicates long noncoding RNA HAND2-AS1 as a potential prognostic, immunomodulatory and therapeutic biomarker in various cancers including colorectal adenocarcinoma DOI Creative Commons
Pouria Samadi, Mina Shahnazari,

Abolfazl Shekari

et al.

Cancer Cell International, Journal Year: 2023, Volume and Issue: 23(1)

Published: Dec. 2, 2023

The HAND2-AS1 (HAND2 Antisense RNA 1) Long noncoding (lncRNA) has emerged as a participant in the initiation of various cancer types, underscoring its pivotal involvement both oncological processes and immune responses. To gain deeper insights into functional nuances identify novel avenues for immunotherapy, comprehensive evaluation this gene was undertaken. Here, based on co-expression network analysis construction interacting lncRNA-mRNA genes, we introduce lncRNA, emphasizing key roles tumorigenesis regulation. Our study spans across 33 distinct revealing HAND2-AS1's aberrant expression patterns, methylation variations, mutational signatures, engagement. Across majority tumors, exhibited propensity down-regulation, remarkably an association with poor survival outcomes. outcomes enrichment analyses strongly suggest engagement tumor progression pathways diverse classifications. Additionally, positive correlation between infiltration levels cells, encompassing not only immunosuppressive entities such tumor-associated macrophages, cancer-associated fibroblasts, Tregs, but also effector cells like NK CD8+ T spanning pan-cancer context. Furthermore, differential appears to have downstream consequences pathways, thus implicating it potential regulator types. Finally, employed CRC normal samples carry out clinical validation HAND2-AS1. unveils suppressor, essential role surveillance. increased emerges promising candidate prognostic evaluation, therapeutic strategy, focal point immunotherapeutic interventions.

Language: Английский

Citations

6
Non-coding RNA profile for natural killer cell activity DOI Creative Commons
Soudeh Ghafouri‐Fard, Arian Askari,

Alireza Zangooie

et al.

Molecular and Cellular Probes, Journal Year: 2023, Volume and Issue: 72, P. 101935 - 101935

Published: Oct. 9, 2023

Natural killer cells (NK cells) are a type of cytotoxic lymphocytes which involved in innate immunity, alongside with assisting adaptive immune response. Since they have effects, disruptions their functionality and development leads to variety conditions, whether malignant or non-malignant. The profile interaction these non-coding RNAs NK different conditions is extensively studied, it now approved that if dysregulated, detrimental effects on cell activity can contribute the pathogenesis diverse disorders. In this review, we aim at thorough inspection role cells, broad spectrum including blood-related disorders, viral infections, neurological diseases, gastrointestinal lung reproductive system other types maladies, providing insight future RNA-NK studies.

Language: Английский

Citations

3
Feature Selection in Cancer Classification: Utilizing Explainable Artificial Intelligence to Uncover Influential Genes in Machine Learning Models DOI Creative Commons
Matheus Dalmolin, Karolayne Azevedo, Luísa C. de Souza

et al.

AI, Journal Year: 2024, Volume and Issue: 6(1), P. 2 - 2

Published: Dec. 27, 2024

This study investigates the use of machine learning (ML) models combined with explainable artificial intelligence (XAI) techniques to identify most influential genes in classification five recurrent cancer types women: breast (BRCA), lung adenocarcinoma (LUAD), thyroid (THCA), ovarian (OV), and colon (COAD). Gene expression data from RNA-seq, extracted The Cancer Genome Atlas (TCGA), were used train ML models, including decision trees (DTs), random forest (RF), XGBoost (XGB), which achieved accuracies 98.69%, 99.82%, 99.37%, respectively. However, challenges this analysis included high dimensionality dataset lack transparency models. To mitigate these challenges, SHAP (Shapley Additive Explanations) method was applied generate a list features, aiming understand characteristics influenced models’ decision-making processes and, consequently, prediction results for tumor types. identified 119, 80, 10 RF, XGB, DT respectively, totaling 209 genes, resulting 172 unique genes. new list, representing 0.8% original input is coherent fully explainable, increasing confidence Additionally, suggest that can be effectively as feature selector gene data. approach not only enhances model but also maintains performance, highlighting its potential identifying biologically relevant features may serve biomarkers diagnostics treatment planning.

Language: Английский

Citations

0
A pan-cancer analysis indicates long noncoding RNA HAND2-AS1 as a potential prognostic, immunomodulatory and therapeutic biomarker in various cancers including colorectal adenocarcinoma DOI Creative Commons
Pouria Samadi, Mina Shahnazari,

Abolfazl Shekari

et al.

Research Square (Research Square), Journal Year: 2023, Volume and Issue: unknown

Published: Aug. 24, 2023

Abstract The HAND2-AS1 (HAND2 Antisense RNA 1) lncRNA has emerged as a participant in the initiation of various cancer types, underscoring its pivotal involvement both oncological processes and immune responses. To gain deeper insights into functional nuances identify novel avenues for immunotherapy, comprehensive evaluation this gene was undertaken. Long noncoding RNAs (lncRNAs) are rising essential regulators expression contributors to modulation. Here, based on co-expression network analysis construction interacting lncRNA-mRNA genes, we introduce lncRNA, emphasizing key roles tumorigenesis regulation. Our study spans across 33 distinct revealing HAND2-AS1's aberrant patterns, methylation variations, mutational signatures, engagement. Across majority tumors, exhibited propensity down-regulation, remarkably an association with poor survival outcomes. outcomes enrichment analyses strongly suggest engagement tumor progression pathways diverse classifications. Additionally, positive correlation between infiltration levels cells, encompassing not only immunosuppressive entities such tumor-associated macrophages, cancer-associated fibroblasts, Tregs, but also effector cells like NK CD8 + T spanning pan-cancer context. Furthermore, differential appears have downstream consequences pathways, thus implicating it potential regulator types. Finally, employed CRC normal samples carry out clinical validation HAND2-AS1. unveils suppressor, role surveillance. heightened emerges promising candidate prognostic evaluation, therapeutic stratagem, focal point immunotherapeutic interventions.

Language: Английский

Citations

0