Exploration of the potential mechanism of Yiyi Tongfeng Formula in the treatment of acute gouty arthritis based on network pharmacology and molecular docking: A review DOI Creative Commons
Bo-yang Tan, Tao Tao,

Dongyang Lin

et al.

Medicine, Journal Year: 2024, Volume and Issue: 103(37), P. e39609 - e39609

Published: Sept. 13, 2024

The global prevalence of gout is on the rise. Yiyi Tongfeng Formula (YTF), a traditional herbal compound, has gained recognition for its efficacy in managing acute gouty arthritis (AGA). Despite widespread use, underlying mechanisms YTF AGA treatment remain largely undefined. This study employed network pharmacology and molecular docking to elucidate these mechanisms. We utilized Traditional Chinese Medicine Systems Pharmacology Database Analysis Platform, SymMap database, various literature sources identify active components corresponding targets YTF. Relevant AGA-associated were identified through Genecards, Drugbank, Therapeutic Target Database, Online Mendelian Inheritance Man databases. A protein–protein interaction was constructed delineate interactions between AGA. Key ingredients central further analyzed using Cytoscape. Functional enrichment analyses, including Gene Ontology Kyoto Encyclopedia Genes Genomes, conducted via Metascape. Additionally, studies performed PyMOL AutoDock4. It found that quercetin, kaempferol, luteolin may be main treatment. analysis shows biological processes involved are cellular responses lipids, inflammatory responses. Genomes suggests involvement IL-17 signaling pathway, AGE–RAGE pathway diabetic complications, TNF so on. findings suggest multi-faceted therapeutic approach treating AGA, involving multiple components, targets, processes, pathways. comprehensive mechanism offers foundation experimental validation.

Language: Английский

Genetically Predicted Plasma Metabolome Mediates the Causal Link Between Immune Cells and Risk of Gout DOI Open Access
Yi Wei, Jiangyi Yu

International Journal of Rheumatic Diseases, Journal Year: 2025, Volume and Issue: 28(2)

Published: Feb. 1, 2025

ABSTRACT Background Gout is a prevalent metabolic disorder characterized by multifaceted process of development. Recent research has emphasized robust correlation between the immune response and gout. Nevertheless, it still uncertain if this connection causative. Hence, objective study was to investigate causal relationship cells gout, while also analyzing role plasma metabolome as mediators in biological process. Methods This explored link different subtypes gout using two‐sample Mendelian randomization (MR). To confirm reliability findings, reverse MR analysis, steiger test sensitivity tests were conducted. A two‐step mediation analysis used gain insight into metabolites intermediate mediators. Results two‐sample, bidirectional, found nominal 33 well 47 known Reverse demonstrated results. In addition, we that Tetradecadienedioate (C14:2‐DC) played partially mediating CD4 on activated regulatory T cell pathways, with proportion 13.16%, (95% CI = 0.65%–25.67%, p 0.034). Conclusion The our possible causative Our findings indicate certain may play association. offers novel insights sources information contribute early detection proactive measures avoid future.

Language: Английский

Citations

0
Potential Molecular Mechanisms of Paederia Foetida L. In Gout Treatment Through Network Pharmacology And Molecular Docking DOI Creative Commons

Hoàng Quoc Tuan,

Hoang Ngoc Phuong Vy,

Nguyễn Thị Thu

et al.

The EuroBiotech Journal, Journal Year: 2025, Volume and Issue: 9(2), P. 138 - 153

Published: April 1, 2025

Abstract The global incidence of gout has been steadily increasing. Paederia foetida L., a traditional medicine, is used to treat in Vietnam, though its active compounds’ molecular mechanisms remain uncertain. This study network pharmacology and docking predict the potential targets pathways P. bioactive components treatment, providing insights for clinical applications. Compounds were identified using TCMSP database, while associated with obtained from GeneCards, TTD, OMIM databases. A Venn diagram was employed determine common targets, Cytoscape software construct compound-target-pathway interaction network. GO KEGG enrichment analyses performed identify key biological processes pathways. AutoDockTools verify between compounds core targets. Five 49 identified. analysis revealed that influenced multiple processes, cellular components, functions. elucidated primary mechanism treatment may be primarily related IL-17 signaling pathway several other anti-inflammatories Molecular confirmed strong binding (affinity < -5 kcal/mol) five protein including TP53, IL6, HSP90AA1, TNF, IL1B, BCL2, PTGS2, MAPK1, MAPK8. Among scores MAPK8 (7.2-10.1 best. Active such as quercetin, beta-sitosterol, kaempferol, pelargonidin, paederosidic acid methyl ester exhibited therapeutic effects on gout. Through silico screening, action treating can determined act through provides more ideas vitro vivo experiments develop herbal medicines treatment.

Language: Английский

Citations

0
Genetic insights into therapeutic targets for gout: evidence from a multi-omics mendelian randomization study DOI Creative Commons
Mingyuan Fan, Zhangjun Yun,

Jiushu Yuan

et al.

Hereditas, Journal Year: 2024, Volume and Issue: 161(1)

Published: Dec. 30, 2024

Abstract Background Considering that the treatment of gout is poor, we performed a Mendelian randomization (MR) study to identify candidate biomarkers and therapeutic targets for gout. Methods A drug-targeted MR was by integrating genome-wide association studies (GWAS) summary data cis expression quantitative trait loci 2,633 druggable genes from multiple cohorts. Summary data-based (SMR) analyses based on transcript protein levels were further implemented validate reliability identified potential Phenome-wide (Phe-MR) analysis conducted in 1403 diseases investigate incidental side effects Results Eight (ALDH3B1, FCGR2B, IL2RB, NRBP1, RCE1, SLC7A7, SUMF1, THBS3) discovery cohort using analysis. Replication meta-analysis replication validated robustness findings ( P < 0.05). Evidence SMR 0.05) strengthened 8 also revealed high ALDH3B1 reduced risk possibly modified methylation site cg25402137. at level added emphasis impact NRBP1 SUMF1 Phe-MR indicated significant causality between 7 causal 45 diseases. Conclusion This several associated with risk, providing new insights into etiology promising development agents.

Language: Английский

Citations

1
Exploration of the potential mechanism of Yiyi Tongfeng Formula in the treatment of acute gouty arthritis based on network pharmacology and molecular docking: A review DOI Creative Commons
Bo-yang Tan, Tao Tao,

Dongyang Lin

et al.

Medicine, Journal Year: 2024, Volume and Issue: 103(37), P. e39609 - e39609

Published: Sept. 13, 2024

The global prevalence of gout is on the rise. Yiyi Tongfeng Formula (YTF), a traditional herbal compound, has gained recognition for its efficacy in managing acute gouty arthritis (AGA). Despite widespread use, underlying mechanisms YTF AGA treatment remain largely undefined. This study employed network pharmacology and molecular docking to elucidate these mechanisms. We utilized Traditional Chinese Medicine Systems Pharmacology Database Analysis Platform, SymMap database, various literature sources identify active components corresponding targets YTF. Relevant AGA-associated were identified through Genecards, Drugbank, Therapeutic Target Database, Online Mendelian Inheritance Man databases. A protein–protein interaction was constructed delineate interactions between AGA. Key ingredients central further analyzed using Cytoscape. Functional enrichment analyses, including Gene Ontology Kyoto Encyclopedia Genes Genomes, conducted via Metascape. Additionally, studies performed PyMOL AutoDock4. It found that quercetin, kaempferol, luteolin may be main treatment. analysis shows biological processes involved are cellular responses lipids, inflammatory responses. Genomes suggests involvement IL-17 signaling pathway, AGE–RAGE pathway diabetic complications, TNF so on. findings suggest multi-faceted therapeutic approach treating AGA, involving multiple components, targets, processes, pathways. comprehensive mechanism offers foundation experimental validation.

Language: Английский

Citations

0