Advances in understanding the role of lncRNA in ferroptosis DOI Creative Commons
Yating Wen,

Wenbo Lei,

Jie Zhang

et al.

PeerJ, Journal Year: 2024, Volume and Issue: 12, P. e17933 - e17933

Published: Aug. 26, 2024

LncRNA is a type of transcript with length exceeding 200 nucleotides, which was once considered junk no biological function during the transcription process. In recent years, lncRNA has been shown to act as an important regulatory factor at multiple levels gene expression, affecting various programmed cell death modes including ferroptosis. Ferroptosis, new form death, characterized by deficiency cysteine or inactivation glutathione peroxidase, leading depletion glutathione, aggregation iron ions, and lipid peroxidation. These processes are influenced many physiological processes, such Nrf2 pathway, autophagy, p53 pathway so on. An increasing number studies have that can block expression specific molecules through decoy effect, guide proteins function, promote interactions between scaffolds. action regulate key factors in metabolism, antioxidant metabolism epigenetic genetic regulation, thereby regulating process this review, we snapshotted mechanism ferroptosis example, emphasizing regulation on these pathways, helping fully understand evolution fate.

Language: Английский

Epigenetic and Post-Translational Modifications in Ferroptosis Regulation and Hepatocellular Carcinoma: New Frontiers in Therapeutic Targeting DOI

Soheil Bolandi,

Samaneh Dodge,

Zahra Zahed

et al.

Pathology - Research and Practice, Journal Year: 2025, Volume and Issue: unknown, P. 155991 - 155991

Published: April 1, 2025

Language: Английский

Citations

0
Advances in understanding the role of lncRNA in ferroptosis DOI Creative Commons
Yating Wen,

Wenbo Lei,

Jie Zhang

et al.

PeerJ, Journal Year: 2024, Volume and Issue: 12, P. e17933 - e17933

Published: Aug. 26, 2024

LncRNA is a type of transcript with length exceeding 200 nucleotides, which was once considered junk no biological function during the transcription process. In recent years, lncRNA has been shown to act as an important regulatory factor at multiple levels gene expression, affecting various programmed cell death modes including ferroptosis. Ferroptosis, new form death, characterized by deficiency cysteine or inactivation glutathione peroxidase, leading depletion glutathione, aggregation iron ions, and lipid peroxidation. These processes are influenced many physiological processes, such Nrf2 pathway, autophagy, p53 pathway so on. An increasing number studies have that can block expression specific molecules through decoy effect, guide proteins function, promote interactions between scaffolds. action regulate key factors in metabolism, antioxidant metabolism epigenetic genetic regulation, thereby regulating process this review, we snapshotted mechanism ferroptosis example, emphasizing regulation on these pathways, helping fully understand evolution fate.

Language: Английский

Citations

1