Artificial Sweeteners: A Double-Edged Sword for Gut Microbiome DOI Creative Commons
Shereen Fawzy,

Nizar Sirag,

Hassabelrasoul Elfadil

et al.

Diseases, Journal Year: 2025, Volume and Issue: 13(4), P. 115 - 115

Published: April 15, 2025

Background and Aim: The human gut microbiome plays a crucial role in maintaining health. Artificial sweeteners, also known as non-nutritive sweeteners (NNS), have garnered attention for their potential to disrupt the balance of microbiome. This review explores complex relationship between NNS microbiome, highlighting benefits risks. By synthesizing current evidence, we aim provide balanced perspective on AS dietary practices health outcomes, emphasizing need targeted research guide safe effective use. Methods: A comprehensive literature was conducted through searches PubMed Google Scholar, focusing effects artificial microbiota. search utilized key terms including “Gut Microbiome”, “gut microbiota”, “Eubiosis”, “Dysbiosis”, “Artificial Sweeteners”, “Nonnutritive Sweeteners”. Results: may alter but findings remain inconsistent. Animal studies often report decrease beneficial bacteria like Bifidobacterium Lactobacillus, an increase harmful strains such Clostridium difficile E. coli, potentially leading inflammation imbalance. Disruptions short-chain fatty acid (SCFA) production hormone signaling been observed. However, generally show milder or no significant changes, limitations translating animal model directly humans. Differences study design, dosage, exposure time, sweetener type likely contribute these varied outcomes. Conclusions: While offer certain benefits, reduced caloric intake improved blood sugar regulation, impact raises important concerns. observed reduction rise pathogenic underscore caution consumption. Furthermore, disruption SCFA metabolic pathways illustrates intricate diet

Language: Английский

Artificial Sweeteners: A Double-Edged Sword for Gut Microbiome DOI Creative Commons
Shereen Fawzy,

Nizar Sirag,

Hassabelrasoul Elfadil

et al.

Diseases, Journal Year: 2025, Volume and Issue: 13(4), P. 115 - 115

Published: April 15, 2025

Background and Aim: The human gut microbiome plays a crucial role in maintaining health. Artificial sweeteners, also known as non-nutritive sweeteners (NNS), have garnered attention for their potential to disrupt the balance of microbiome. This review explores complex relationship between NNS microbiome, highlighting benefits risks. By synthesizing current evidence, we aim provide balanced perspective on AS dietary practices health outcomes, emphasizing need targeted research guide safe effective use. Methods: A comprehensive literature was conducted through searches PubMed Google Scholar, focusing effects artificial microbiota. search utilized key terms including “Gut Microbiome”, “gut microbiota”, “Eubiosis”, “Dysbiosis”, “Artificial Sweeteners”, “Nonnutritive Sweeteners”. Results: may alter but findings remain inconsistent. Animal studies often report decrease beneficial bacteria like Bifidobacterium Lactobacillus, an increase harmful strains such Clostridium difficile E. coli, potentially leading inflammation imbalance. Disruptions short-chain fatty acid (SCFA) production hormone signaling been observed. However, generally show milder or no significant changes, limitations translating animal model directly humans. Differences study design, dosage, exposure time, sweetener type likely contribute these varied outcomes. Conclusions: While offer certain benefits, reduced caloric intake improved blood sugar regulation, impact raises important concerns. observed reduction rise pathogenic underscore caution consumption. Furthermore, disruption SCFA metabolic pathways illustrates intricate diet

Language: Английский

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