Platelet-rich fibrin in dentistry DOI Creative Commons

Ping Song,

Dawei He, Song Ren

et al.

Journal of Applied Biomaterials & Functional Materials, Journal Year: 2024, Volume and Issue: 22

Published: Jan. 1, 2024

Objectives: To review the progress of Platelet Rich Fibrin (PRF) as a biomaterial in dentistry and to highlight its promising application safe biocompatible autologous platelet concentrate. Publications were searched GeenMedical, X-mol, GoogleScholar, PubMed from October 2024 with no language restrictions. The literature was for relevant databases journals on use PRFs up 2024, inclusion criteria included randomized controlled trials, clinical case series, systematic reviews. Conclusion: PRF is second-generation concentrate that sourced oneself, has fewer adverse effects, simple prepare. These materials include growth factors fibrin scaffolds, which are extensively utilized regenerative medicine. By outlining PRF, we found good results can be achieved when used treat these conditions. Clinical significance: widespread, particularly periodontal soft hard tissue regeneration, oral lichen planus, pulpal regeneration. This article reviews background, classification, preparation methods PRFs, along their dental applications. We anticipate further research various derivatives future, will significantly improve utilization applications offer fresh insights diagnosing treating diseases.

Language: Английский

Platelet-rich fibrin obtained from different protocols affects the formation of the in vitro multispecies subgingival biofilm associated with periodontitis DOI Creative Commons

Fábio Hideaki Uyeda,

G Vargas, Larissa Matias Malavazi

et al.

Journal of Oral Microbiology, Journal Year: 2025, Volume and Issue: 17(1)

Published: Jan. 1, 2025

The aim of this article is to evaluate the effect different portions Platelet Rich Fibrin (PRF) membranes and liquid-PRF, prepared by two distinct protocols/centrifuges each, on multispecies subgingival biofilm. PRF liquid-PRF were using protocols: centrifuge 1 uses fixed acceleration while 2, progressive acceleration. samples introduced into device concurrently with 33-species bacterial inoculum. After seven days, biofilm metabolic activity (MA) microbial profile evaluated through colorimetric reaction DNA-DNA hybridization, respectively. Among membranes, ones from led better reduction in MA, total biofilm, F. periodonticum, P. gingivalis T. forsythia counts when compared untreated/centrifuge 2 treated biofilms. However, reduced periodonticum treated-biofilms. membrane exhibited comparable antibiofilm activity. forms, obtained same centrifugation protocol, may present antimicrobial properties.

Language: Английский

Citations

0
Does platelet‐rich fibrin enhance the outcomes of peri-implant soft tissues? A systematic review DOI Creative Commons
Enrica Giammarinaro, Nicola Baldini, Ugo Covani

et al.

BMC Oral Health, Journal Year: 2025, Volume and Issue: 25(1)

Published: April 22, 2025

Language: Английский

Citations

0
PRF and PRP in Dentistry: An Umbrella Review DOI Open Access
Alfonso Acerra,

Mario Caggiano,

Andrea Chiacchio

et al.

Journal of Clinical Medicine, Journal Year: 2025, Volume and Issue: 14(9), P. 3224 - 3224

Published: May 6, 2025

Introduction: Platelet-rich fibrin (PRF) and platelet-rich plasma (PRP) utilize autologous blood share the objective of leveraging blood-derived growth factors to enhance body’s natural healing process. A large extensive use has been made in various branches dentistry. Methods: total 4175 records were identified from electronic search, specifically 291 BioMed Central, 3406 MEDLINE/PubMed, 304 Cochrane library databases, 174 PROSPERO register. This review was performed relation PRISMA flow chart annotated Results: In total, 3416 title abstracts screened, a 40 systematic reviews finally included present umbrella review. Conclusions: Research supports PRF PRP different fields is huge potential for patient but also doctor as these products are have zero cost. However, further studies needed, especially RCTs, clearer evidence on role PRP.

Language: Английский

Citations

0
Radiographic Evaluation in Alveolar Preservation Using Platelet-Rich Fibrin: A Randomized Controlled Trial DOI Creative Commons
Magdalena Molina-Barahona,

J Castillo,

Esteban Freire-Meza

et al.

Dentistry Journal, Journal Year: 2025, Volume and Issue: 13(6), P. 231 - 231

Published: May 23, 2025

Background: Tooth extractions commonly result in dimensional changes of the alveolar ridge. Platelet-rich fibrin (PRF) has emerged as a promising autologous biomaterial for preservation. This randomized controlled trial aimed to evaluate, through cone beam computed tomography (CBCT), effect PRF maintaining dimensions post-extraction. Methods: A single-blind, clinical was conducted 10 systemically healthy patients requiring premolar orthodontic reasons. total 36 alveoli were analyzed: 19 with (experimental group) and 17 without (control group). CBCT scans performed at baseline, 30 days, 120 days post-extraction measure height, vestibulo-palatal/lingual depth 1, 3, 5 mm, bone tissue density using Hounsfield Units (HU). Results: Baseline cephalocaudal height similar both groups (~10.5 p = 0.399). At preservation significantly greater group (10.61 mm vs. 8.82 < 0.001). maintained (10.30 9.31 mm), although this difference not statistically significant (p 0.059). No differences observed or > 0.05). The showed trend toward better higher mean values (190–282 HU), no formal statistical comparison HU performed. Repeated measures ANOVA revealed interaction time on 0.010, η2 0.046) 1 0.035, 0.020). Conclusions: improved short-term Trends group, these findings significant. appears be safe potential support ridge maintenance

Language: Английский

Citations

0
Evaluation of the usefulness of platelet-rich fibrin (PRF) in mandibular third molar surgery with 3D facial swelling analysis: a split-mouth randomized clinical trial DOI Creative Commons
Selene Barone, Francesco Bennardo, Marianna Salviati

et al.

Head & Face Medicine, Journal Year: 2025, Volume and Issue: 21(1)

Published: Feb. 22, 2025

Third molar surgery is associated with various postoperative complications (PC). Different strategies, including the application of platelet-rich fibrin (PRF), have been implemented to reduce PC. Digital technologies proven useful in objectively assessing facial swelling. This study aimed evaluate effect PRF on reducing swelling after lower third using a 3D face scanner. A randomized split-mouth clinical trial was set up and 32 patients (18 years), requiring extraction both mandibular molars, were recruited at Oral Surgery Clinic Magna Graecia University Catanzaro. The primary predictive variable or not plugs membranes post-extraction socket. Primary outcome recorded scanner preoperatively (T0), three (T1) seven (T2) days. Qualitative quantitative data analysis conducted following an automated standardized imaging workflow Slicer software. Secondary variables trismus, by measuring maximum buccal opening caliper, pain, visual analogue scale (VAS), duration surgery. Descriptive bivariate performed setting significance level $$\:\alpha\:$$ = 0.05. All exhibited significant increase T1, followed subsequent reduction from day 3 7, slight persistence edema observed seventh day. No emerged statistical conducted. Linear differences group reported improved values only T1-T2 T0-T2 phases analysis. Volumetric favored compared control all phases. VAS T2, group. Application sockets showed effectiveness Its advantages, accessibility, cost-effectiveness, absence adverse reactions, make it optimal treatment choice post-surgical sequelae.

Language: Английский

Citations

0
Platelet-Rich Fibrin Increases CXCL8 Expression in Gingival Fibroblasts DOI Creative Commons

Atefe Imani,

Layla Panahipour, Natália dos Santos Sanches

et al.

Biomedicines, Journal Year: 2024, Volume and Issue: 12(6), P. 1326 - 1326

Published: June 14, 2024

Platelet-rich fibrin (PRF), the coagulated plasma of fractionated blood, is widely used to support tissue regeneration in dentistry, and underlying cellular molecular mechanisms are increasingly being understood. Periodontal connective tissues steadily express CXCL8, a chemokine that attracts granulocytes lymphocytes, supporting homeostatic immunity. Even though PRF considered dampen inflammation, it should not be ruled out increases expression CXCL8 gingival fibroblasts. To test this hypothesis, we conducted bioassay where fibroblasts were exposed lysates respective serum. We show here and, lesser extent, serum increased by fibroblasts, as confirmed immunoassay. SB203580, inhibitor p38 mitogen-activated protein kinase, reduced expression. Consistently, weaker range, also caused phosphorylation Assuming rich source growth factors, TGF-β receptor type I kinase SB431542 decreased PRF-induced translation CXCL8. The findings suggest drive activating signaling

Language: Английский

Citations

2
Platelet-rich fibrin in dentistry DOI Creative Commons

Ping Song,

Dawei He, Song Ren

et al.

Journal of Applied Biomaterials & Functional Materials, Journal Year: 2024, Volume and Issue: 22

Published: Jan. 1, 2024

Objectives: To review the progress of Platelet Rich Fibrin (PRF) as a biomaterial in dentistry and to highlight its promising application safe biocompatible autologous platelet concentrate. Publications were searched GeenMedical, X-mol, GoogleScholar, PubMed from October 2024 with no language restrictions. The literature was for relevant databases journals on use PRFs up 2024, inclusion criteria included randomized controlled trials, clinical case series, systematic reviews. Conclusion: PRF is second-generation concentrate that sourced oneself, has fewer adverse effects, simple prepare. These materials include growth factors fibrin scaffolds, which are extensively utilized regenerative medicine. By outlining PRF, we found good results can be achieved when used treat these conditions. Clinical significance: widespread, particularly periodontal soft hard tissue regeneration, oral lichen planus, pulpal regeneration. This article reviews background, classification, preparation methods PRFs, along their dental applications. We anticipate further research various derivatives future, will significantly improve utilization applications offer fresh insights diagnosing treating diseases.

Language: Английский

Citations

0