[18F]PSMA-1007 PET/CT-based radiomics may help enhance the interpretation of bone focal uptakes in hormone-sensitive prostate cancer patients

European Journal of Nuclear Medicine and Molecular Imaging, Journal Year: 2025, Volume and Issue: unknown

Published: Jan. 28, 2025

Abstract Purpose We hypothesised that applying radiomics to [ 18 F]PSMA-1007 PET/CT images could help distinguish Unspecific Bone Uptakes (UBUs) from bone metastases in prostate cancer (PCa) patients. compared the performance of radiomic features human visual interpretation. Materials and methods retrospectively analysed 102 hormone-sensitive PCa patients who underwent exhibited at least one focal uptake with known clinical follow-up (reference standard). Using matRadiomics, we extracted PET CT each identified best predictor model for using a machine-learning approach generate score. Blinded readers low ( n = 2) high experience rated as either UBU or metastasis. The same performed second read three months later, access Results Of 178 uptakes, 74 (41.5%) were classified by reference standard. A combining achieved an accuracy 84.69%, though it did not surpass expert round. Less-experienced had significantly lower diagnostic baseline p < 0.05) but improved addition scores 0.05 first round). Conclusion Radiomics might differentiate UBUs. While exceed assessments, has potential enhance less-experienced evaluating uptakes.

Language: Английский

Preclinical Implementation of matRadiomics: A Case Study for Early Malformation Prediction in Zebrafish Model

Journal of Imaging, Journal Year: 2024, Volume and Issue: 10(11), P. 290 - 290

Published: Nov. 14, 2024

Radiomics provides a structured approach to support clinical decision-making through key steps; however, users often face difficulties when switching between various software platforms complete the workflow. To streamline this process, matRadiomics integrates entire radiomics workflow within single platform. This study extends

Language: Английский