A computational model for complete separation of circulating tumor cells inside grooved microchannel under the effect of dielectrophoretic forces DOI
Anupam Neogi, Niraj Kr Prasad, Siddhartha Sankar Ghosh

et al.

Physics of Fluids, Journal Year: 2025, Volume and Issue: 37(5)

Published: May 1, 2025

Understanding the separation of particles inside a microchannel offers greater insights into several crucial issues, such as circulating tumor cells (CTCs) for early cancer detection and red blood (RBCs) white (WBCs) from samples. Various microfluidic devices have been developed to successfully separate samples under effect various forces. These forces include hydrodynamic forces, electric magnetic acoustic However, complete efficiency has not yet achieved with these devices. Thus, attempts were made conduct simulation study completely CTCs RBCs, WBCs, platelets in grooved microchannel. Particle tracing laminar flow module was employed model platelets, Newtonian medium. A 100% dielectrophoretic channel. Studies also conducted discern that significantly reduces non-grooved In addition, maximum transmissivity 98% reported CTCs. It is eight flat-shaped electrodes operating voltage range 6–7 V. The results will be extended fabricate can Furthermore, revealed significance separating different sizes.

Language: Английский

A computational model for complete separation of circulating tumor cells inside grooved microchannel under the effect of dielectrophoretic forces DOI
Anupam Neogi, Niraj Kr Prasad, Siddhartha Sankar Ghosh

et al.

Physics of Fluids, Journal Year: 2025, Volume and Issue: 37(5)

Published: May 1, 2025

Understanding the separation of particles inside a microchannel offers greater insights into several crucial issues, such as circulating tumor cells (CTCs) for early cancer detection and red blood (RBCs) white (WBCs) from samples. Various microfluidic devices have been developed to successfully separate samples under effect various forces. These forces include hydrodynamic forces, electric magnetic acoustic However, complete efficiency has not yet achieved with these devices. Thus, attempts were made conduct simulation study completely CTCs RBCs, WBCs, platelets in grooved microchannel. Particle tracing laminar flow module was employed model platelets, Newtonian medium. A 100% dielectrophoretic channel. Studies also conducted discern that significantly reduces non-grooved In addition, maximum transmissivity 98% reported CTCs. It is eight flat-shaped electrodes operating voltage range 6–7 V. The results will be extended fabricate can Furthermore, revealed significance separating different sizes.

Language: Английский

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