Recent Methods for Modifying Mechanical Properties of Tissue-Engineered Scaffolds for Clinical Applications

Biomimetics, Journal Year: 2023, Volume and Issue: 8(2), P. 205 - 205

Published: May 16, 2023

The limited regenerative capacity of the human body, in conjunction with a shortage healthy autologous tissue, has created an urgent need for alternative grafting materials. A potential solution is tissue-engineered graft, construct which supports and integrates host tissue. One key challenges fabricating graft achieving mechanical compatibility site; disparity these properties can shape behaviour surrounding native contributing to likelihood failure. purpose this review examine means by researchers have altered constructs via hybrid material usage, multi-layer scaffold designs, surface modifications. subset studies investigated function their vivo also presented, followed examination various designs been clinically translated.

Language: Английский

An open-source, battery-powered, low-cost, and dual-channel pneumatic pulse generator for microfluidic cell-stretch assays

HardwareX, Journal Year: 2024, Volume and Issue: 20, P. e00595 - e00595

Published: Oct. 11, 2024

Language: Английский

Experimental Validation of an Organ-on-Chip for Mechanical Stimulation of Cell Cultures

bioRxiv (Cold Spring Harbor Laboratory), Journal Year: 2023, Volume and Issue: unknown

Published: Dec. 15, 2023

Abstract This paper focuses on the design, fabrication, and characterization of a platform aiming to dynamically culture cells under mechanical stimulation. The platform, made polymethylmethacrylate (PMMA), allows real-time stimuli, providing valuable insights for living tissue models. Through testing dynamic microfluidic tests, chip functionality was assessed. experimental results validation showcases potential device in mimicking physiological conditions, offering promising avenue pharmaceutical advancement.

Language: Английский