Effect of Mg incorporation on the properties of PCL/Mg composites for potential tissue engineering applications DOI Creative Commons
Sumama Nuthana Kalva, Fawad Ali,

Kripa S Keyan

et al.

Frontiers in Materials, Journal Year: 2024, Volume and Issue: 11

Published: April 8, 2024

Polycaprolactone (PCL) is a biocompatible polymer readily moldable into various shapes and designs. However, its low mechanical strength slow biodegradation restrict use in tissue engineering. Magnesium (Mg), metal with excellent osteoconductivity biodegradability, promising choice for engineering applications. This study investigates the influence of Mg incorporation on properties PCL/Mg composites, aiming to evaluate their suitability 3D-printable (3DP) We synthesized series composites varying concentrations characterized mechanical, thermal, degradation properties. According microscopic analysis composite films, particles are dispersed consistently throughout all compositions. The findings demonstrated that adding influenced PCL’s thermal test results showed tensile 15% filaments improved by around 10% compared neat PCL filaments. elastic modulus decreased 50% same composition. revealed significant reduction temperature from above 400°C pure 300°C having Mg. Additionally, weight loss during vitro presence had significantly increased rate samples. Also, influences cell adhesion, better attachment observed 3DP Overall, offer solution overcome limitation thermo-mechanical typically associated PCL.

Language: Английский

Recent Advances in the Additive Manufacturing of Stimuli‐Responsive Soft Polymers DOI Creative Commons
Ali Tariq, Zia Ullah Arif, Muhammad Yasir Khalid

et al.

Advanced Engineering Materials, Journal Year: 2023, Volume and Issue: 25(21)

Published: Aug. 29, 2023

Stimuli‐responsive polymers (SRPs) are special types of soft materials, which have been extensively used for developing flexible actuators, robots, wearable devices, sensors, self‐expanding structures, and biomedical thanks to their ability change shapes functional properties in response external stimuli including light, humidity, heat, pH, electric field, solvent, magnetic field or combinations two more these stimuli. In recent years, additive manufacturing (AM) aka 3D printing technology SRPs, also known as 4D printing, has gained phenomenal attention different engineering fields, its unique develop complex, personalized, innovative undergo twisting, elongating, swelling, rolling, shrinking, bending, spiraling, other complex morphological transformations. Herein, an effort made provide insightful information about the AM techniques, type applications including, but not limited tissue engineering, bionics, construction, smart textiles. This article incorporates current challenges prospects, hoping basis utilization this fields. It is expected that amalgamation with SRPs would unparalleled advantages arenas.

Language: Английский

Citations

84

3D printing of magneto-active smart materials for advanced actuators and soft robotics applications DOI Creative Commons
Muhammad Yasir Khalid, Zia Ullah Arif, Ali Tariq

et al.

European Polymer Journal, Journal Year: 2024, Volume and Issue: 205, P. 112718 - 112718

Published: Jan. 2, 2024

In the contemporary era, novel manufacturing technologies like additive (AM) have revolutionized different engineering sectors including biomedical, aerospace, electronics, etc. Four-dimensional (4D) printing aka AM of smart materials is gaining popularity among scientific community, which has excellent ability to make soft structures such as robots, actuators, and grippers. These are developed by applying various stimuli pH, temperature, magnetic field, many combinations onto materials. Stimuli in 3D permit shape-morphing behaviors bending, twisting, folding, swelling, rolling, shrinking, origami, or locomotion. A wide variety can be fabricated through incorporation hard particles into resulting magneto-active (MASMs). With this integration, magneto-thermal coupling actuation allows diverse magneto-deformations, facilitating development personalized devices that capable enhanced deformation. review, guidelines provided on for MASMs polymers (MAPs), composites, hydrogels (MAHs) booming flexible wearable biomimetic devices. Moreover, 3D-printed robotics an outstanding capacity adapt complicated situations advanced actuating applications. Finally, some current challenges emerging areas exciting technology been proposed. Lastly, it anticipated technological advancements developing intelligent will a significant impact design real-world

Language: Английский

Citations

71

Biofabrication methods for reconstructing extracellular matrix mimetics DOI Creative Commons
Abdellah Aazmi, Duo Zhang,

Corrado Mazzaglia

et al.

Bioactive Materials, Journal Year: 2023, Volume and Issue: 31, P. 475 - 496

Published: Sept. 9, 2023

In the human body, almost all cells interact with extracellular matrices (ECMs), which have tissue and organ-specific compositions architectures. These ECMs not only function as cellular scaffolds, providing structural support, but also play a crucial role in dynamically regulating various functions. This comprehensive review delves into examination of biofabrication strategies used to develop bioactive materials that accurately mimic one or more biophysical biochemical properties ECMs. We discuss potential integration these ECM-mimics range physiological pathological vitro models, enhancing our understanding behavior organization. Lastly, we propose future research directions for context engineering organ-on-a-chip applications, offering advancements therapeutic approaches improved patient outcomes.

Language: Английский

Citations

54

4D printing roadmap DOI Creative Commons
Mahdi Bodaghi, Linlin Wang, Fenghua Zhang

et al.

Smart Materials and Structures, Journal Year: 2024, Volume and Issue: 33(11), P. 113501 - 113501

Published: June 26, 2024

Abstract Four-dimensional (4D) printing is an advanced manufacturing technology that has rapidly emerged as a transformative tool with the capacity to reshape various research domains and industries. Distinguished by its integration of time dimension, 4D allows objects dynamically respond external stimuli, setting it apart from conventional 3D printing. This roadmap been devised, contributions 44 active researchers in this field 32 affiliations world-wide, navigate swiftly evolving landscape printing, consolidating recent advancements making them accessible experts across diverse fields, ranging biomedicine aerospace, textiles electronics. The roadmap’s goal empower both enthusiasts, facilitating exploitation printing’s potential create intelligent, adaptive are not only feasible but readily attainable. By addressing current future challenges proposing science technology, sets stage for revolutionary progress numerous industries, positioning future.

Language: Английский

Citations

26

Polymer Composites in 3D/4D Printing: Materials, Advances, and Prospects DOI Creative Commons
Ayyaz Mahmood,

Fouzia Perveen,

Shenggui Chen

et al.

Molecules, Journal Year: 2024, Volume and Issue: 29(2), P. 319 - 319

Published: Jan. 9, 2024

Additive manufacturing (AM), commonly referred to as 3D printing, has revolutionized the landscape by enabling intricate layer-by-layer construction of three-dimensional objects. In contrast traditional methods relying on molds and tools, AM provides flexibility fabricate diverse components directly from digital models without need for physical alterations machinery. Four-dimensional printing is a revolutionary extension that introduces dimension time, dynamic transformations in printed structures over predetermined periods. This comprehensive review focuses polymeric materials exploring their versatile processing capabilities, environmental adaptability, applications across thermoplastics, thermosetting materials, elastomers, polymer composites, shape memory polymers (SMPs), including liquid crystal elastomer (LCE), self-healing 4D printing. also examines recent advancements microvascular encapsulation mechanisms, explores potential supramolecular polymers, highlights latest progress hybrid using polymer-metal polymer-ceramic composites. Finally, this paper offers insights into challenges faced additive composites suggests avenues future research rapidly evolving field.

Language: Английский

Citations

17

The Role of Polysaccharide-based Biodegradable Soft Polymers in the Healthcare Sector DOI Creative Commons
Zia Ullah Arif

Advanced Industrial and Engineering Polymer Research, Journal Year: 2024, Volume and Issue: unknown

Published: May 1, 2024

Bio-based polymers have garnered significant interest across the manufacturing industry, global economy, and various engineering disciplines such as packaging, tissue engineering, controlled drug delivery, wound dressing, textiles. In current era, bio-based polymers, notably polysaccharides, offer a promising platform for constructing intricate versatile structures in biomedical sector. These encompass applications regenerative medicine (TERM), delivery devices, coatings wearable sensors, thanks to their distinctive features inherent biocompatibility, flexibility, stretchability, mechanical strength, renewability, physiological activity, favorable biological environment. this review, we concise overview of diverse types polysaccharide-based composites, properties, interactions with specific cells tissues. The review encompasses recent progress scaffolds designed cartilage, skin, neural, vascular, cardiac, bone regeneration, employing both conventional modern techniques. Additionally, it delves into development other biodegradable including systems (DDSs), antibacterial on medical electronic devices healthcare Furthermore, also elucidates research directions future perspectives while emphasizing importance regulatory approvals commitment environmental sustainability. This well-organized critical is expected assist practitioners researchers gaining deeper understanding trends, challenges, potential solutions, thereby harnessing immense biomaterials system. utilization polysaccharides sector aligns principles nature, contributing reduction carbon dioxide emissions supporting Sustainable Development Goals United Nations.

Language: Английский

Citations

17

Shape-memory and self-healing properties of sustainable cellulosic nanofibers-based hybrid materials for novel applications DOI Creative Commons
Muhammad Yasir Khalid, Zia Ullah Arif, Ans Al Rashid

et al.

Giant, Journal Year: 2024, Volume and Issue: 19, P. 100299 - 100299

Published: June 5, 2024

In the era of smart and sustainable technology driven by naturally occurring materials, various nanocellulose-based materials play a crucial role. Shape memory behaviour self-healing capabilities nanocelluloses are emerging as focal points in numerous research domains. Nanocellulose its derivatives such cellulose nanocrystals (CNC) nanofibers (CNF), currently limelight due to their excellent shape-memory properties, making them suitable for multifunctional devices. this regard, CNF, cutting-edge material, has spurred researchers explore potential developing contemporary personalized health Therefore, timely comprehensive review is essential gain deep insights into effectiveness CNF Herein, we first provide succinct introduction all nanocellulose materials. This also depicts recent advancements breakthroughs large effective synthesis CNF-based hybrid Next, focusing on performance, sheds new light advanced applications Finally, perspectives current challenges opportunities field summarized future an in-depth understanding "CNF-based materials."

Language: Английский

Citations

16

Progress in hydrogel toughening: addressing structural and crosslinking challenges for biomedical applications DOI Creative Commons
Md. Mahamudul Hasan Rumon, Md. Sohanur Rahman, Anwarul Azim Akib

et al.

Discover Materials, Journal Year: 2025, Volume and Issue: 5(1)

Published: Jan. 9, 2025

Achieving the ideal replacement for robust biological tissues requires biocompatible materials with a nuanced blend of characteristics, including organ specific toughness, durability, self-repairing capability, and well-defined structure. Hydrogels, structured high water containing 3D-crosslinked polymeric networks, present promising avenue in biomedical applications due to their close resemblance natural tissues. However, mechanical performance often falls short, limiting clinical applications. Recent research has been focused on developing hydrogel therapeutic advancements have spurred researchers develop hydrogels having acceptable toughness. While it is now possible tailor properties synthetic gels mimic those tissues, critical aspects such as biocompatibility crosslinking strategies are frequently neglected. This review scrutinizes structural techniques designed improve toughness hydrogels, focusing especially innovative efforts integrate these enhancements into natural-based hydrogels. By thoroughly examining methodologies, sheds light complexities strengthening will propose valuable insights development next-generation tissue substitutes.

Language: Английский

Citations

7

4D printing: innovative solutions and technological advances in orthopedic repair and reconstruction, personalized treatment and drug delivery DOI Creative Commons
Chenxi Shen, Ao Shen

BioMedical Engineering OnLine, Journal Year: 2025, Volume and Issue: 24(1)

Published: Jan. 21, 2025

With precise control of smart materials deformation in time dimension, doctors can customize orthopedic implants. This review focuses on the advances 4D printing technology orthopedics, including its applications bone repair and reconstruction, personalized treatment, drug delivery. enables creation bionic scaffolds fixation devices for repair, customized implants matching patients' conditions specific carriers accurate release delivery, which together contribute to accelerating healing, providing exclusive treatments, enhancing therapeutic effects reducing side effects, thus helping improve medicine. It offers comprehensive reference relevant medical personnel.

Language: Английский

Citations

3

Experimental and numerical evaluations of flexible filter paper substrates for sensitive and rapid identification of methyl parathion pesticide via Surface-enhanced Raman scattering (SERS) DOI

Saeideh Mehmandoust,

Hossein Sahbafar,

Atefe Mohsennezhad

et al.

Vibrational Spectroscopy, Journal Year: 2023, Volume and Issue: 129, P. 103586 - 103586

Published: Aug. 25, 2023

Language: Английский

Citations

23