Elsevier eBooks, Journal Year: 2024, Volume and Issue: unknown
Published: Jan. 1, 2024
Language: Английский
Plasmonics, Journal Year: 2025, Volume and Issue: unknown
Published: Jan. 21, 2025
Language: Английский
Citations
2
Biofabrication, Journal Year: 2024, Volume and Issue: 17(1), P. 012005 - 012005
Published: Nov. 8, 2024
Abstract Artificial bone graft stands out for avoiding limited source of autograft as well susceptibility to infection allograft, which makes it a current research hotspot in the field defect repair. However, traditional design and manufacturing method cannot fabricate scaffold that mimics complicated bone-like shape with interconnected porous structure multiple properties akin human natural bone. Additive manufacturing, can achieve implant’s tailored external contour controllable fabrication internal microporous structure, is able form almost any designed via layer-by-layer process. As additive promising building artificial scaffold, only combining excellent structural appropriate process produce ideal biological mechanical properties. In this article, we sum up analyze state art methods realize shape/properties collaborative intelligent manufacturing. Scaffold be mainly classified into based on unit cells whole while basic 3D bioprinting are recommended suitable fabrication. The challenges future perspectives manufactured also discussed.
Language: Английский
Citations
9
Transplant International, Journal Year: 2024, Volume and Issue: 37
Published: Oct. 14, 2024
The field of organ transplantation is experiencing a transformative shift with the rise Advanced Therapy Medicinal Products (ATMPs), which include gene therapies, somatic cell and tissue-engineered products. These therapies offer new, potentially curative treatments for longstanding medical challenges, impacting numerous patients. However, their adoption hindered by complex regulatory frameworks, high production costs, inconsistent access across Europe. ESOT ATMP Task Force’s position paper analyzes these challenges from research to clinical application, advocating coordinated strategy Europe as leader in development. It proposes specific actions such streamlining pathways accelerate approvals, boosting funding research, creating specialized facilities development implementation. also highlights critical roles patient engagement real-world evidence optimizing practices.
Language: Английский
Citations
4
Biotechnology Journal, Journal Year: 2025, Volume and Issue: 20(1)
Published: Jan. 1, 2025
ABSTRACT Osteochondral damage, caused by trauma, tumors, or degenerative diseases, presents a major challenge due to the limited self‐repair capacity of tissue. Traditional treatments often result in significant trauma and unpredictable outcomes. Recent advances bone/cartilage tissue engineering, particularly scaffold materials fabrication technologies, offer promising solutions for osteochondral regeneration. This review highlights selection design scaffolds using natural synthetic such as collagen, chitosan (Cs), polylactic acid (PLA), alongside inorganic components like bioactive glass nano‐hydroxyapatite (nHAp). Key techniques—freeze‐drying, electrospinning, 3D printing—have improved porosity mechanical properties. Special focus is placed on multiphasic that mimic structures, promoting cell adhesion differentiation supporting regeneration cartilage subchondral bone. In addition, current obstacles future directions regenerating damaged tissues will be discussed.
Language: Английский
Citations
0
Materials & Design, Journal Year: 2025, Volume and Issue: unknown, P. 113792 - 113792
Published: March 1, 2025
Language: Английский
Citations
0
Regenerative Biomaterials, Journal Year: 2025, Volume and Issue: 12
Published: Jan. 1, 2025
The mandible is the largest craniofacial bone and plays a crucial role in speech, mastication, swallowing, facial aesthetics. form or function of can be altered by defects as result tumors, trauma, infection, congenital conditions. This paper covers evolution biomaterials-based approaches to reconstruction critical size mandibular defects. Historically gold standard for defect repair has been autologous fibula grafts. emergence field tissue engineering led current research on biomaterial scaffolds, cells, biological factors design highly tunable, bio-inspired, regenerative implants. Scaffold materials synthetic natural fabricated using variety additive manufacturing techniques. Mesenchymal stem morphogenetic proteins, transforming growth factor-β are frequently added scaffolds. While great progress made, there still barriers translating this patients, ranging from insufficient regeneration animal studies feasibility establishing good practice. To address these challenges, future will look toward improving implant vascularization innervation, personalizing shape biology, enhancing spatiotemporal control drug release. With goals mind, researchers ultimately develop biomaterials that regenerate structurally biologically identical native tissue, both quality life patients.
Language: Английский
Citations
0
Journal of Functional Biomaterials, Journal Year: 2025, Volume and Issue: 16(5), P. 176 - 176
Published: May 13, 2025
In this study, a scaffold was designed using 3-Matic software 12.0 (Materialise, Leuven, Belgium) and fabricated via Digital Light Processing (DLP) 3D printing technology, followed by mechanical property evaluation. The bilaterally implanted into mandibular bone defect models in four Beagle dogs to facilitate guided alveolar regeneration. After 12 weeks, samples were harvested from two for radiographic histopathological evaluations. the remaining dogs, dental implants placed sites. an additional further assessments. (1) Compression testing of demonstrated compressive strength 24.77 ± 2.36 MPa. (2) Three implantation sites exhibited poor wound healing exposure grafts early post-surgery (4 weeks), with rate 37.5%. (3) Micro-CT imaging revealed uniform distribution newly formed within scaffold, average height 4.05 0.55 mm volume fraction 43.93 4.68%. Histopathological analysis presence vascularized tissue, non-calcified bone, calcified scaffold. Additionally, tissue observed at interface between implant These findings suggest that DLP 3D-printed A-W bioactive glass scaffolds represent promising approach regeneration applications.
Language: Английский
Citations
0
Deleted Journal, Journal Year: 2024, Volume and Issue: 3(4), P. 200157 - 200157
Published: July 7, 2024
Three-dimensional (3D) bioprinting, which has been applied in tissue engineering and regenerative medicine, uses biomaterials, cells, other essential components to manufacture organs tissues with specific biological functions complex structures. Over the past 30 years, researchers have developed new 3D bioprinting technologies improved manufacturing capabilities expanded applications. Chinese research teams contributed significantly this process. In paper, we first reviewed development history major milestones categorizing them into two main strategies: "biomaterial-based indirect assembly" "living cell-based direct assembly". This review further delved technical principles, recent advancements, advantages, disadvantages, applications of each type technology. Finally, challenges future directions were summarized guide China foster advancements dynamic field.
Language: Английский
Citations
3
Journal of Manufacturing Processes, Journal Year: 2024, Volume and Issue: 130, P. 1 - 34
Published: Sept. 5, 2024
Language: Английский
Citations
3
Materials, Journal Year: 2024, Volume and Issue: 17(21), P. 5305 - 5305
Published: Oct. 31, 2024
The emerging paradigm of personalised bone repair embodies a transformative triad comprising bio-inspired design, digital fabrication, and the exploration innovative materials. increasing average age population, alongside rising incidence fractures associated with age-related conditions such as osteoporosis, necessitates development customised, efficient, minimally invasive treatment modalities alternatives to conventional methods (e.g., autografts, allografts, Ilizarov distraction, fixators) typically employed promote regeneration. A promising technique involves use cellularised scaffolds incorporating mesenchymal stem cells (MSCs). selection materials—ranging from metals ceramics synthetic or natural bio-derived polymers—combined design inspired by sources (including bone, corals, algae, shells, silk, plants) facilitates replication geometries, architectures, porosities, biodegradation capabilities, mechanical properties conducive physiological To mimic internal structures geometries for construct customisation, can be designed using Computer-aided Design (CAD) fabricated via 3D-printing techniques. This approach not only enables precise control over external shapes architectures but also accommodates diverse materials that improve biological performance provide economic advantages. Finally, advanced numerical models are simulate, analyse, optimise complex processes involved in regeneration, computational predictions validated against experimental data vivo studies ascertain model’s ability predict recovery shape function.
Language: Английский
Citations
2