Detection of Advanced Glycation End Product Precursors in Chocolates Enriched with Lyophilised Cornus mas L. DOI
Zehra Margot Çelik, Aybike Cebeci, Güleren Sabuncular

et al.

Frontiers in Life Sciences and Related Technologies, Journal Year: 2024, Volume and Issue: unknown

Published: Dec. 5, 2024

Advanced glycation end product (AGEs) precursors, glyoxal (GO) and methylglyoxal (MGO), are toxic compounds formed during food processing through the Maillard reaction and, protein lipid oxidation. Chocolate, a widely consumed product, has been extensively studied for its health effects contains AGEs their which associated with many chronic inflammatory diseases. Cornelian cherry (Cornus mas L.), naturally grown in Türkiye, is rich antioxidants, vitamin C, anthocyanins, flavonoids, phenolic compounds. Fruits natural antioxidant content known to reduce AGE formation. This study aimed investigate changes GO MGO levels by adding various amounts (10 g, 15 20 g) of lyophilized Cornus L. powder different types chocolate (dark, milk, white). precursors analysis was performed using High-Performance Liquid Chromatography (HPLC). Additionally, sensory conducted determine consumption potential chocolates. Fourteen panellists aged 18-65 evaluated samples single-blind method tasting completing questionnaire. Data were reported SPSS 26.0 software package. contents ranged from 14 268.6 µg/100g, while 122.3 284 µg/100g. It observed that only milk did decrease increased In analysis, among groups, most preferred after control groups white 10 g (3.86 ± 0.86). Significant differences found terms taste, bitterness, melting mouth, texture, hardness, sourness, overall acceptance (p

Language: Английский

Emerging technologies in reducing dietary advanced glycation end products in ultra‐processed foods: Formation, health risks, and innovative mitigation strategies DOI Open Access

Shenwan Wang,

Xiaoyan Zheng, Yang Yang

et al.

Comprehensive Reviews in Food Science and Food Safety, Journal Year: 2025, Volume and Issue: 24(2)

Published: Feb. 19, 2025

Abstract The widespread consumption of ultra‐processed foods (UPFs) results from industrialization and globalization, with their elevated content sugar, fat, salt, additives, alongside the formation dietary advanced glycation end products (AGEs), generating considerable health risks. These risks include an increased incidence diabetes, cardiovascular diseases, neurodegenerative disorders. This review explores mechanisms AGE in UPFs evaluates emerging technologies additives aimed at mitigating these Both thermal methods (air frying, low‐temperature vacuum heating, microwave infrared heating) non‐thermal techniques (high‐pressure processing, pulsed electric fields, ultrasound, cold plasma) are discussed for potential reduction. Additionally, efficacy exogenous including amino acids, polysaccharides, phenolic compounds, nanomaterials, inhibiting formation, though may vary depending on specific additive food matrix. findings demonstrate promise reducing AGEs, potentially contributing to healthier processing practices promotion improved public outcomes.

Language: Английский

Citations

2
Superoxide Dismutase Glycation: A Contributor to Disease and Target for Prevention DOI Open Access
Masood Alam Khan, Hina Younus

Catalysts, Journal Year: 2025, Volume and Issue: 15(3), P. 247 - 247

Published: March 5, 2025

Superoxide dismutase (SOD), a key antioxidant enzyme, plays crucial role in neutralizing reactive oxygen species (ROS) and maintaining redox balance. However, SOD is highly susceptible to glycation, non-enzymatic modification induced by reducing sugars carbonyl such as methylglyoxal. This review aims provide comprehensive analysis of examining its biochemical mechanisms, impact on enzymatic function, the progression oxidative stress-related diseases. Additionally, it explores potential therapeutic strategies prevent glycation restore activity, highlighting translational applications for disease management. The examines research pathological consequences diabetes complications, neurodegenerative disorders, cardiovascular Key interventions, including advanced end-product (AGE) inhibitors (aminoguanidine, pyridoxamine), antioxidants (N-acetylcysteine, alpha-lipoic acid), mimetics (MnTBAP, Tempol), enzyme stabilizers (thymoquinone, alliin), receptor end-products (RAGE) blockade, are analyzed their efficacy mitigating stress. reduces leading elevated ROS levels inflammation. Glycated interacts with RAGE, increasing stress biomarkers. AGE reduce stress, whereas lower levels. up 85% protect from structural degradation. monoclonal antibodies targeting RAGE have been shown inflammatory cytokines improve mitochondrial function. major contributor Preventing restoring function through multifaceted approach progression. By elucidating pathogenesis, this contributes advancement targeted therapies conditions, diabetes, neurodegeneration,

Language: Английский

Citations

1
Fluorescence in probing the biochemical and conformational changes in non-enzymatically glycated proteins DOI Creative Commons

K Ameera,

Darshan Chikkanayakanahalli Mukunda,

Shaik Basha

et al.

Applied Spectroscopy Reviews, Journal Year: 2025, Volume and Issue: unknown, P. 1 - 33

Published: March 23, 2025

Language: Английский

Citations

1
Phytochemical Composition and Functional Properties of Brassicaceae Microgreens: Impact of In Vitro Digestion DOI Open Access
Ivana Šola, Valerija Vujčić, Maja Popović

et al.

International Journal of Molecular Sciences, Journal Year: 2024, Volume and Issue: 25(21), P. 11831 - 11831

Published: Nov. 4, 2024

The aim of this study was to compare the concentration phenolic compounds, glucosinolates, proteins, sugars and vitamin C between kohlrabi (Brassica oleracea var. acephala gongylodes), Savoy cabbage (B. sabauda), Brussels sprouts gemmifera), cauliflower botrytis), radish (Raphanus sativus) garden cress (Lepidium sativum) microgreens for their antioxidant hypoglycemic potential. In addition, we applied an in vitro-simulated system human digestion order track bioaccessibility selected representatives, stability microgreens’ potential terms α-amylase α-glucosidase inhibition after each phase. Using spectrophotometric RP-HPLC methods with statistical analyses, found that had lowest soluble sugar content, while highest glucosinolate levels (76.21 ± 4.17 mg SinE/g dm 77.73 3.33 dm, respectively). were most effective at inhibiting protein glycation (37.98 2.30% inhibition). A very high positive correlation (r = 0.830) antiglycation conjugated sinapic acid recorded. For first time, antidiabetic vitro studied. Kohlrabi best inhibited both initial intestinal (60.51 3.65% 62.96 3.39% inhibition, respectively), also showed strongest post-digestion (19.22 0.08% sprouts, cauliflower, less stable than inhibitors during digestion. Kohlrabi, cabbage, retained enzymes capacity remained unchanged greatest variability seen original samples, phase resulted convergence, indicating reduced differences samples. conclusion, highlights various as sources bioactive compounds properties. Notably, demonstrated significant enzyme digestion, suggesting promise managing carbohydrate metabolism supporting metabolic health.

Language: Английский

Citations

3
Nuclear Factor-Kappa-B Mediates the Advanced Glycation End Product-Induced Repression of Slc2a4 Gene Expression in 3T3-L1 Adipocytes DOI Open Access
Maria Luiza Estimo Michalani, Marisa Passarelli, Ubiratan Fabres Machado

et al.

International Journal of Molecular Sciences, Journal Year: 2024, Volume and Issue: 25(15), P. 8242 - 8242

Published: July 28, 2024

Advanced glycated end products (AGEs) are cytotoxic compounds that mainly increased in diabetes mellitus (DM), kidney failure, inflammation, and response to the ingestion of AGE-rich diets. AGEs can also impair glycemic homeostasis by decreasing expression

Language: Английский

Citations

1
Cardamonin Attenuates Myocardial Ischemia/Reperfusion-Induced Ferroptosis Through Promoting STAT3 Signaling DOI Creative Commons
Tao Yang,

Pengcui Wu,

Luping Jiang

et al.

Journal of Inflammation Research, Journal Year: 2024, Volume and Issue: Volume 17, P. 8861 - 8879

Published: Nov. 1, 2024

Ferroptosis is intricately associated with the pathophysiology processes of myocardial ischemia. Cardamonin (CAR) has been shown to provide significant protection against tissue damage due multiple ischemia/reperfusion. This study aimed examine cardioprotective properties CAR in ischemia/reperfusion injury (MIRI) and insights into possible mechanisms involved.

Language: Английский

Citations

1
Trends in research on advanced glycation end products (AGEs) DOI Creative Commons
Hermann M. Bolt, Jan G. Hengstler

Archives of Toxicology, Journal Year: 2024, Volume and Issue: 98(11), P. 3515 - 3517

Published: Oct. 10, 2024

Language: Английский

Citations

0
Cancerous Conditions Accelerate the Aging of Skeletal Muscle via Mitochondrial DNA Damage DOI Open Access
Yi Luo,

Rina Fujiwara‐Tani,

Isao Kawahara

et al.

International Journal of Molecular Sciences, Journal Year: 2024, Volume and Issue: 25(13), P. 7060 - 7060

Published: June 27, 2024

Skeletal muscle aging and sarcopenia result in similar changes the levels of markers. However, few studies have examined cancer from perspective aging. Therefore, this study investigated explored its causes vitro vivo. In mouse aging, cachexia, cachexia models, skeletal muscles showed markers including oxidative stress, fibrosis, reduced differentiation potential, telomere shortening. Furthermore, examination mitochondrial DNA revealed a 5 kb deletion major arc; truncation complexes I, IV, V electron transport chain; phosphorylation (OXPHOS). The model demonstrated high high-mobility group box-1 (HMGB1) tumor necrosis factor-α (TNFα) ascites. Continuous administration neutralizing antibodies against HMGB1 TNFα stress abrogated deletion. These results suggest that sarcopenia, caused by inflammatory cytokines leads to damage, which turn decreased OXPHOS promotion

Language: Английский

Citations

0
Detection of Advanced Glycation End Product Precursors in Chocolates Enriched with Lyophilised Cornus mas L. DOI
Zehra Margot Çelik, Aybike Cebeci, Güleren Sabuncular

et al.

Frontiers in Life Sciences and Related Technologies, Journal Year: 2024, Volume and Issue: unknown

Published: Dec. 5, 2024

Advanced glycation end product (AGEs) precursors, glyoxal (GO) and methylglyoxal (MGO), are toxic compounds formed during food processing through the Maillard reaction and, protein lipid oxidation. Chocolate, a widely consumed product, has been extensively studied for its health effects contains AGEs their which associated with many chronic inflammatory diseases. Cornelian cherry (Cornus mas L.), naturally grown in Türkiye, is rich antioxidants, vitamin C, anthocyanins, flavonoids, phenolic compounds. Fruits natural antioxidant content known to reduce AGE formation. This study aimed investigate changes GO MGO levels by adding various amounts (10 g, 15 20 g) of lyophilized Cornus L. powder different types chocolate (dark, milk, white). precursors analysis was performed using High-Performance Liquid Chromatography (HPLC). Additionally, sensory conducted determine consumption potential chocolates. Fourteen panellists aged 18-65 evaluated samples single-blind method tasting completing questionnaire. Data were reported SPSS 26.0 software package. contents ranged from 14 268.6 µg/100g, while 122.3 284 µg/100g. It observed that only milk did decrease increased In analysis, among groups, most preferred after control groups white 10 g (3.86 ± 0.86). Significant differences found terms taste, bitterness, melting mouth, texture, hardness, sourness, overall acceptance (p

Language: Английский

Citations

0