The Involvement and Manifestations of SARS-CoV-2 Virus in Cardiovascular Pathology DOI Creative Commons

Sofia Teodora Hărșan,

Anca Sin

Medicina, Journal Year: 2025, Volume and Issue: 61(5), P. 773 - 773

Published: April 22, 2025

Although the acute phase of COVID-19 pandemic has subsided, emergence post-COVID-19 condition presents a new and complex public health challenge, characterized by persistent, multisystem symptoms that can endure for weeks or months after initial infection with SARS-CoV-2 virus, significantly affecting survivors’ quality life. Among most concerning sequelae are cardiovascular complications, which encompass broad spectrum conditions, including arrhythmias, myocardial damage, postural orthostatic tachycardia syndrome. This narrative review explores burden on reviewing latest relevant findings in literature highlighting different aspects COVID-19’s involvement. investigates pathophysiological mechanisms underlying involvement condition, focus direct viral invasion via ACE2 receptors, immune-mediated injury, cytokine storm, systemic inflammation, endothelial dysfunction, mitochondrial injury. The interplay between pre-existing diseases, such as hypertension, atherosclerosis, diabetes, atrial fibrillation, is also explored, revealing individuals conditions at heightened risk both severe illness long-term complications. Long-term immune activation persistence antigens increasingly recognized contributors to ongoing even mild asymptomatic infections. As healthcare system continues adapt consequences pandemic, deeper understanding these manifestations essential. knowledge will inform development targeted strategies prevention, clinical management, rehabilitation affected patients. Furthermore, insights gained from intersection be instrumental shaping responses future epidemics, necessity multidisciplinary approaches patient care preparedness.

Language: Английский

Heart rate variability modulation through slow paced breathing in Healthcare workers with Long-COVID: a case-control study DOI Creative Commons
Marcella Mauro,

Cegolon Luca,

Bestiaco Nicoletta

et al.

The American Journal of Medicine, Journal Year: 2024, Volume and Issue: unknown

Published: May 1, 2024

Language: Английский

Citations

5
Skeletal muscle adaptations and post-exertional malaise in long COVID DOI Creative Commons
Braeden T. Charlton, Richie P. Goulding, Richard T. Jaspers

et al.

Trends in Endocrinology and Metabolism, Journal Year: 2024, Volume and Issue: unknown

Published: Dec. 1, 2024

When acute SARS-CoV-2 infections cause symptoms that persist longer than 3 months, this condition is termed long COVID. Symptoms experienced by patients often include myalgia, fatigue, brain fog, cognitive impairments, and post-exertional malaise (PEM), which the worsening of following mental or physical exertion. There little consensus on pathophysiology exercise-induced PEM skeletal-muscle-related symptoms. In opinion article we highlight intrinsic mitochondrial dysfunction, endothelial abnormalities, a muscle fiber type shift towards more glycolytic phenotype as main contributors to reduced exercise capacity in The mechanistic trigger for induce unknown, but rapid skeletal tissue damage intramuscular infiltration immune cells contribute PEM-related

Language: Английский

Citations

5
Long COVID: Clinical Findings, Pathology, and Endothelial Molecular Mechanisms DOI
H. Bradford Hawley

The American Journal of Medicine, Journal Year: 2023, Volume and Issue: unknown

Published: Sept. 1, 2023

Language: Английский

Citations

11
Potential Beneficial Effects of Naringin and Naringenin on Long COVID—A Review of the Literature DOI Creative Commons
Siqi Liu,

Mengli Zhong,

Hao Wu

et al.

Microorganisms, Journal Year: 2024, Volume and Issue: 12(2), P. 332 - 332

Published: Feb. 4, 2024

Coronavirus disease 2019 (COVID-19) caused a severe epidemic due to acute respiratory syndrome coronavirus-2 (SARS-CoV-2). Recent studies have found that patients do not completely recover from infections, but instead, suffer variety of post-acute sequelae SARS-CoV-2 infection, known as long COVID. The effects COVID can be far-reaching, with duration up six months and range symptoms such cognitive dysfunction, immune dysregulation, microbiota dysbiosis, myalgic encephalomyelitis/chronic fatigue syndrome, myocarditis, pulmonary fibrosis, cough, diabetes, pain, reproductive thrombus formation. However, recent shown naringenin naringin palliative on various COVID-19 sequelae. Flavonoids naringenin, commonly in fruits vegetables, positive effects, including reducing inflammation, preventing viral providing antioxidants. This article discusses the molecular mechanisms clinical treating above diseases. It proposes them potential drugs for treatment COVID, it inferred exhibit extended medications, future likely serving nutraceuticals or supplements comprehensive alleviation manifestations complications.

Language: Английский

Citations

4
Advances in researches on long coronavirus disease in children: a narrative review DOI Open Access

Jiaqian Zhang,

Taiji Kuang,

Xinglou Liu

et al.

Translational Pediatrics, Journal Year: 2024, Volume and Issue: 13(2), P. 318 - 328

Published: Feb. 1, 2024

In the context of global pandemic coronavirus disease 2019 (COVID-19), more than 700 million infections and millions deaths have occurred in countries around world. Currently, two main sequelae this are considered to occur children, namely, multi-system inflammatory syndrome children long COVID. Among these two, incidence COVID is higher its impact on population extensive, which focus us. However, due lack relevant studies limitations most studies, COVID-19 infection lag behind those adults, but they begun attract attention some clinicians researchers. We aim summarize current knowledge helping pediatricians researchers better understand providing guidance research clinical treatment it.

Language: Английский

Citations

4
Long COVID across SARS‐CoV‐2 variants: Clinical features, pathogenesis, and future directions DOI Creative Commons
Laurence S. C. Lok,

Shuvam Sarkar,

Chi‐Ming Lam

et al.

MedComm – Future Medicine, Journal Year: 2024, Volume and Issue: 3(4)

Published: Dec. 1, 2024

Abstract Long coronavirus disease (COVID) is characterized by persistent symptoms following severe acute respiratory syndrome 2 (SARS‐CoV‐2) infection and has emerged as a significant health concern. As SARS‐CoV‐2 evolved from the wild‐type strain to Alpha, Beta, Delta, Omicron variants, there may be variant‐specific influence on long COVID akin disease. This review aims summarize our current knowledge of influences in incidence, symptom profile well mechanisms pathogenesis. We highlight that incidence lower with variants. The also show some dependence different reduction cardiopulmonary more recent heterogeneity related differences affecting immune system, viral persistence, autoimmunity. However, emerging data suggest vaccinations play big role shaping presentation COVID. ongoing work profiles populations infected only will beneficial toward useful definitions development effective diagnostic therapeutic strategies.

Language: Английский

Citations

4
Treatment with Sulodexide Downregulates Biomarkers for Endothelial Dysfunction in Convalescent COVID-19 Patients DOI Creative Commons
Alejandro J. Gonzalez-Ochoa, Győző Szolnoky,

Ana G Hernandez-Ibarra

et al.

Clinical and Applied Thrombosis/Hemostasis, Journal Year: 2025, Volume and Issue: 31

Published: Jan. 1, 2025

Introduction Persistent elevation of biomarkers associated with endothelial dysfunction in convalescent COVID-19 patients has been linked to an increased risk long-term cardiovascular complications, including long COVID syndrome. Sulodexide, known for its vascular affinity, demonstrated pleiotropic protective properties. This study aims evaluate the impact sulodexide on serum levels during phase COVID-19. Methods We conducted a double-blind, single-center, randomized, placebo-controlled trial Mexico, comparing (250 LRU orally, twice daily) placebo over 8 weeks adult early convalescence. Differences between groups were analyzed using repeated measures and post hoc tests, Thrombomodulin (TM) as primary endpoint. Results Among 206 (103 each group), at week 8, group exhibited significantly lower mean (25.2 ± 7.9 ng/mL vs 29.9 14.7 ng/mL, P = .03), von Willebrand Factor (vWF) (232 131 U/dL 266 122 U/dL, .02) Interleukin-6 (IL-6) (12.5 13.2 pg/mL 16.2 16.5 pg/mL, .03) compared group. D-dimer C reactive protein (CRP) also lowered. No significant differences observed P-selectin, fibrinogen, VCAM-1, or ICAM-1 levels. Conclusions Patients who received eight showed reduction TM, vWF, D-dimer, CRP, IL-6 placebo. These findings suggest potential effect against thromboinflammation damage.

Language: Английский

Citations

0
SARS-CoV-2 S-protein expression drives syncytia formation in endothelial cells DOI Creative Commons
Katie V. Tieu,

Michael Graham Espey,

Aarthi Narayanan

et al.

Scientific Reports, Journal Year: 2025, Volume and Issue: 15(1)

Published: Jan. 28, 2025

SARS-CoV-2 is a viral infection, best studied in the context of epithelial cell infection. Epithelial cells, when infected with express S-protein, which causes host cells to fuse together into large multi-nucleated known as syncytia. Because infections also frequently present cardiovascular phenotypes, we sought understand if S-protein expression would result syncytia formation endothelial cells. was sufficient induce an average 10% all forming 6 nuclei per after 72 h expression. Formation associated gaps between suggesting potential for compromise barrier function. Inhibition myosin light chain kinase (MLCK), but not Rho-associated protein kinase, inhibited syncytia, role MLCK formation. Further supporting cellular contractility formation, observed reduction occurrence grown on substrates reduced stiffness. are exposed physiological forces due blood flow, examined effects cyclic biaxial stretch and fluid shear stress. While did affect stress were more resistant Finally, that suitable infection replication, Our studies indicate addition should be considered target driver COVID-19-associated pathology.

Language: Английский

Citations

0
Serotonergic psychedelics as potential therapeutics for post-COVID-19 syndrome (or Long COVID): A comprehensive review DOI
Zhen Xuen Brandon Low, Shin Jie Yong, Hayam A Alrasheed

et al.

Progress in Neuro-Psychopharmacology and Biological Psychiatry, Journal Year: 2025, Volume and Issue: unknown, P. 111279 - 111279

Published: Feb. 1, 2025

Language: Английский

Citations

0
Circulating Autoantibodies Against Vasoactive Biomarkers Related to Orthostatic Intolerance in Long COVID Patients Compared to No-Long-COVID Populations: A Case-Control Study DOI Creative Commons
Emilie Han, Katrin Zlabinger, Ena Hašimbegović

et al.

Biomolecules, Journal Year: 2025, Volume and Issue: 15(2), P. 300 - 300

Published: Feb. 18, 2025

Endothelial dysfunction mediated by elevated levels of autoantibodies against vasoactive peptides occurring after COVID-19 infection is proposed as a possible pathomechanism for orthostatic intolerance in long COVID patients. This case-control study comprised 100 patients from our prospective POSTCOV registry and three control groups, each consisting 20 individuals (Asymptomatic post-COVID group; Healthy group = pan-negative antispike protein SARS-CoV-2; Vaccinated healthy no history vaccinated). Autoantibodies towards muscarinic acetylcholine receptor M3, endothelin type A (ETAR), beta-2 adrenergic (Beta-2 AR), angiotensin II 1 1-7 (Ang1-7) concentrations were measured enzyme-linked immunosorbent assay controls. Orthostatic was defined inappropriate sinus tachycardia, postural hypotonia other dysautonomia symptoms, such dizziness or blurred vision (n 38 patients). Autoantibody compared with routine laboratory parameters quality life questionnaires (EQ-5D). The concentration ETAR significantly higher COVID, Asymptomatic groups to the group. trend plasma Beta-2 AR Ang1-7 patients, not related presence intolerance. autoantibody showed significant positive correlation EQ-5D item "Problems performing usual activities".

Language: Английский

Citations

0