Modulation of blood-tumor barrier transcriptional programs improves intratumoral drug delivery and potentiates chemotherapy in GBM

Science Advances, Journal Year: 2025, Volume and Issue: 11(9)

Published: Feb. 26, 2025

Efficient drug delivery to glioblastoma (GBM) is a major obstacle as the blood-brain barrier (BBB) and blood-tumor (BTB) prevent passage of majority chemotherapies into brain. Here, we identified transcriptional 12-gene signature associated with BTB in GBM. We CDH5 core molecule this set confirmed its expression GBM vasculature using transcriptomics immunostaining patient specimens. The indirubin-derivative, 6-bromoindirubin acetoxime (BIA), down-regulates other genes, causing endothelial disruption vitro murine xenograft models. Treatment BIA increased intratumoral cisplatin accumulation potentiated DNA damage by targeting repair pathways. Last, an injectable nanoparticle formulation, PPRX-1701, significantly improved efficacy Our work reveals potential targets bifunctional properties modulator potentiator chemotherapy, supporting further development.

Language: Английский

Cellular role of CD93 and its potential as a future therapeutic target

Expert Opinion on Therapeutic Targets, Journal Year: 2025, Volume and Issue: unknown

Published: April 29, 2025

Language: Английский

CLEC14A facilitates angiogenesis and alleviates inflammation in diabetic wound healing

Life Sciences, Journal Year: 2024, Volume and Issue: 358, P. 123176 - 123176

Published: Oct. 24, 2024

Language: Английский