Contemporary Clinical Trials Communications,
Journal Year:
2023,
Volume and Issue:
36, P. 101219 - 101219
Published: Oct. 2, 2023
Deimplementing
overused
health
interventions
is
essential
to
maximizing
quality
and
value
while
minimizing
harm,
waste,
inefficiencies.
Three
national
guidelines
discourage
continuous
pulse
oximetry
(SpO2)
monitoring
in
children
who
are
not
receiving
supplemental
oxygen,
but
the
guideline-discordant
practice
remains
prevalent,
making
it
a
prime
target
for
deimplementation.
This
paper
details
statistical
analysis
plan
Eliminating
Monitor
Overuse
(EMO)
SpO2
trial,
which
compares
effect
of
two
competing
deimplementation
strategies
(unlearning
only
vs.
unlearning
plus
substitution)
on
sustainment
with
bronchiolitis
room
air.The
EMO
Trial
hybrid
type
3
effectiveness-deimplementation
trial
longitudinal
cluster-randomized
design,
conducted
Pediatric
Research
Inpatient
Settings
Network
hospitals.
The
primary
outcome
sustainment,
analyzed
as
difference-in-differences
comparison
between
study
arms.
will
use
generalized
hierarchical
mixed-effects
models
clustering
outcomes.
Secondary
outcomes
include
length
hospital
stay
oxygen
supplementation
duration,
modeled
using
linear
regressions.
Using
well-established
counterfactual
approach,
we
also
perform
mediation
hospital-level
mechanistic
measures
association
strategy
outcome.We
anticipate
that
advance
science
by
providing
new
insights
into
processes,
mechanisms,
likelihood
sustained
change
rigorously
designed
strategies.
pre-specified
mitigate
reporting
bias
support
data-driven
approaches.ClinicalTrials.gov
NCT05132322.
Registered
24
November
2021.
Implementation Science,
Journal Year:
2024,
Volume and Issue:
19(1)
Published: March 28, 2024
Abstract
Background
Theory
and
correlational
research
indicate
organizational
leadership
climate
are
important
for
successful
implementation
of
evidence-based
practices
(EBPs)
in
healthcare
settings;
however,
experimental
evidence
is
lacking.
We
addressed
this
gap
using
data
from
the
WISDOM
(Working
to
Implement
Sustain
Digital
Outcome
Measures)
hybrid
type
III
effectiveness-implementation
trial.
Primary
outcomes
indicated
Leadership
Organizational
Change
Implementation
(LOCI)
strategy
improved
fidelity
measurement-based
care
(MBC)
youth
mental
health
services.
In
study,
we
tested
LOCI’s
hypothesized
mechanisms
change,
namely:
(1)
LOCI
will
improve
transformational
leadership,
which
turn
(2)
mediate
effect
on
climate,
(3)
MBC
fidelity.
Methods
Twenty-one
outpatient
clinics
serving
were
randomly
assigned
plus
training
technical
assistance
or
only.
Clinicians
rated
their
leaders’
clinic
at
five
time
points
(baseline,
4-,
8-,
12-,
18-months
post-baseline).
was
assessed
electronic
metadata
outpatients
who
initiated
treatment
12
months
following
training.
Hypotheses
longitudinal
mixed-effects
models
multilevel
mediation
analyses.
Results
significantly
baseline
follow-up
18-month
post-baseline
(all
p
s
<
.01),
producing
large
effects
(range
ds
=
0.76
1.34).
small
4
(
d
0.31,
.019)
nonsignificant
thereafter
>
.05).
improvement
mediated
by
(proportion
[
m
]
0.82,
.004).
Transformational
did
not
0.136).
Improvement
during
same
period
0.71,
.045).
Conclusions
services
improving
itself
increased
leadership.
Fidelity
EBPs
settings
can
be
developing
leaders
strong
climates.
Trial
registration
ClinicalTrials.gov
identifier:
NCT04096274.
Registered
September
18,
2019.
Journal of the American Academy of Child & Adolescent Psychiatry,
Journal Year:
2023,
Volume and Issue:
63(10), P. 991 - 1004
Published: Dec. 7, 2023
Objective
Measurement-based
care
(MBC),
which
collects
session-by-session
symptom
data
from
patients
and
provides
clinicians
with
feedback
on
treatment
response,
is
a
highly
generalizable
evidence-based
practice
significant
potential
to
improve
the
outcomes
of
mental
health
in
youth
when
implemented
fidelity;
however,
it
rarely
used
community
settings.
This
study
tested
whether
an
implementation
strategy
targeting
organizational
leadership
climate
could
MBC
fidelity
clinical
for
outpatient
clinics.
Method
In
cluster
randomized
trial,
21
clinics
were
assigned
Leadership
Organizational
Change
Implementation
plus
training
technical
assistance
(k
=
11,
n
117)
or
only
10,
117).
Primary
(assessed
via
electronic
metadata)
improvement
caregiver-reported
change
Shortform
Assessment
Children
Total
Problem
Score)
collected
consecutively
enrolled
youths
(ages
4-18
years)
who
initiated
12
months
following
training.
Outcomes
each
assessed
6
baseline.
Results
A
total
234
included
intent-to-treat
analyses.
At
baseline,
there
no
differences
by
condition
clinic,
clinician,
characteristics.
Youths
using
experienced
significantly
higher
compared
control
(23.1%
vs
3.4%,
p
.014),
exhibited
greater
reductions
symptoms
baseline
(d
0.31,
95%
CI:
0.04-0.58,
.023).
Conclusion
strategies
focused
can
practices
services.
Clinical
trial
registration
information
Working
Implement
Sustain
Digital
Outcome
Measures
(WISDOM);
https://clinicaltrials.gov/;
NCT04096274.
Clinical Trials,
Journal Year:
2025,
Volume and Issue:
unknown
Published: Jan. 10, 2025
Background:
Implementation
and
hybrid
effectiveness–implementation
trials
aspire
to
speed
the
translation
of
science
into
practice
by
generating
crucial
evidence
for
improving
uptake
effective
health
interventions.
By
design,
they
pose
unique
recruitment
retention
challenges
due
their
aims,
units
analysis,
sampling
plans,
which
typically
require
many
clinical
sites
(i.e.
often
20
or
more)
participation
individuals
who
are
related
across
multiple
levels
(e.g.
linked
organizational
leaders,
clinicians,
patients).
In
this
article,
we
present
a
new
multilevel,
theory-informed,
relationship-centered
framework
conceptualizing
in
implementation
integrates
builds
on
prior
work
strategies
patient-focused
trials.
We
describe
framework’s
application
Working
Implement
Sustain
Digital
Outcome
Measures
type
III
trial,
occurred
part
during
COVID-19
pandemic.
Methods:
Recruitment
trial
from
October
2019
February
2022.
Development
was
guided
newly
developed
multilevel
framework,
targeted
capability,
opportunity,
motivation
patient-facing
administrative
staff,
patients
engage
research.
A
structured
assessment
guide
applied
refine
approaches
throughout
trial.
its
amid
onset
pandemic
required
rapid
adjustments
address
numerous
barriers.
Results:
The
enrolled
21
outpatient
clinics
three
US
states,
incorporating
252
clinicians
686
caregivers
youth
(95%
patient
target)
two
distinct
phases.
Data
completion
rates
leaders
averaged
90%
over
five
waves
spanning
18
months,
despite
COVID
Caregiver
monthly
follow-up
assessments
ranged
80%–88%
6
months.
This
article
presents
guide,
used
achieve
targets
at
each
level.
Conclusion:
conducted
multi-state
that
maintained
high
all
relevant
global
presented
here,
behavioral
theory,
relationship-focused
lens,
evidence-based
participant
levels,
can
be
adapted
other
researchers
implementation,
hybrid,
pragmatic
as
well
studies.
Psychiatric Services,
Journal Year:
2025,
Volume and Issue:
unknown
Published: Jan. 30, 2025
Little
is
known
about
how
to
sustain
evidence-based
interventions
with
fidelity
in
community
mental
health
settings.
Phase
1
of
the
Working
Implement
and
Sustain
Digital
Outcome
Measures
(WISDOM)
trial
showed
that
an
organizational
strategy
improved
implementation
measurement-based
care
(MBC)
services
for
youths
1-12
months
after
clinician
MBC
training.
The
authors
report
results
from
phase
2
trial,
which
strategy's
effects
on
sustainment
13-26
training
were
examined.
Twenty-one
outpatient
clinics
randomly
assigned
technical
assistance
plus
Leadership
Organizational
Change
Implementation
(LOCI)
(11
clinics)
or
only
(10
clinics).
In
2,
primary
outcomes
completion
rate,
youth
symptom
improvement,
examined
452
who
entered
treatment
No
differences
found
rate
improvement
between
two
conditions;
however,
among
81
received
MBC,
was
significantly
higher
at
LOCI
sites
relative
control
(24%,
SE=11.1
vs.
1%,
SE=1.0,
respectively;
p=0.003).
During
(vs.
sites)
sustained
superior
when
used;
rates
clinical
not
sustained.
Sustainment
may
require
strategies
improve
its
fit
regulatory
reimbursement
environments
addition
develop
clinic
infrastructure.
Administration and Policy in Mental Health and Mental Health Services Research,
Journal Year:
2024,
Volume and Issue:
52(1), P. 159 - 170
Published: April 8, 2024
Abstract
Despite
its
demonstrated
value,
many
mental
health
institutions
struggle
to
implement
progress
feedback
effectively.
There
is
also
insufficient
information
about
how
therapists
utilize
feedback.
To
gain
more
insight,
two
qualitative
studies
were
conducted.
The
first
study
compared
the
attitudes
and
motives
of
who
used
those
did
not
use
second
examined
psychologists
incorporated
into
their
practice.
In
total,
23
interviewed,
data
analyzed
using
thematic
analysis.
found
that
almost
all
had
a
positive
attitude
Those
it
indicated
reasons
such
as
heavy
workload
patient-related
factors,
they
lacked
sufficient
potential
benefits
revealed
four
major
ways
in
which
utilized
feedback,
namely:
supporting
actions
discuss
discussing
with
patients,
modifications
ongoing
treatment,
peer
consultation.
However,
discussions
during
consultations
for
patients
benefitting
from
treatment
might
be
adjusted
accordingly
often
lacking.
conclusion,
crucial
training
education
provided
on
Having
regular
could
facilitate
integration
clinical
Implementation Science Communications,
Journal Year:
2023,
Volume and Issue:
4(1)
Published: July 11, 2023
Abstract
Background
Leaders
can
improve
implementation
outcomes
by
developing
an
organizational
climate
conducive
to
the
of
evidence-based
practices
(EBP).
This
study
tested
lagged
associations
between
individual-level
perceptions
leadership,
climate,
and
three
anticipated
outcomes,
that
is
EBP
acceptability,
appropriateness,
feasibility.
Methods
Screening
tools
treatment
methods
for
posttraumatic
stress
disorder
were
implemented
in
43
Norwegian
mental
health
services.
A
sample
494
child
adult
care
professionals
(
M
=
years,
78%
female)
completed
surveys
addressing
first-level
leaders’
n
47)
leadership
their
clinics’
climate.
Single-level
structural
equation
models
estimating
both
direct,
indirect,
total
effects
used
investigate
whether
perceived
mediated
association
feasibility
screening
methods.
Results
Regarding
methods,
was
associated
with
therapists’
Implementation
also
outcomes.
tools,
not
However,
acceptability
feasibility,
but
appropriateness.
Analyses
subscales
showed
stronger
than
tools.
Conclusions
may
promote
positive
directly
through
With
regard
effect
sizes
explained
variance,
results
indicated
more
strongly
one
group
therapists,
all
therapists.
imply
have
smaller
teams
within
a
larger
system
system-wide
implementations
or
when
clinical
interventions
being
are
complex
rather
simple
ones.
Trial
registration
ClinicalTrials
NCT03719651,
25
October
2018.