Molecular and Cellular Probes,
Journal Year:
2024,
Volume and Issue:
75, P. 101961 - 101961
Published: April 8, 2024
As
one
of
the
earliest
discovered
lncRNA
molecules,
H19
is
usually
expressed
in
large
quantities
during
embryonic
development
and
involved
cell
differentiation
tissue
formation.
In
recent
years,
role
tumors
has
been
gradually
recognized.
Increasing
evidence
suggests
that
its
aberrant
expression
closely
related
to
cancer
development.
LncRNA
as
an
oncogene
not
only
promotes
growth,
proliferation,
invasion
metastasis
many
tumors,
but
also
develops
resistance
treatment,
affecting
patients'
prognosis
survival.
Therefore,
this
review,
we
summarise
extensive
research
on
involvement
tumor
progression
discuss
how
H19,
a
key
target
gene,
affects
sensitivity
radiotherapy,
chemotherapy
immunotherapy
by
participating
multiple
cellular
processes
regulating
signaling
pathways,
which
provides
promising
prospect
for
further
into
treatment
cancer.
Frontiers in Cardiovascular Medicine,
Journal Year:
2022,
Volume and Issue:
9
Published: Oct. 28, 2022
In
recent
years,
the
mechanism
of
cell
death
has
become
a
hotspot
in
research
on
pathogenesis
and
treatment
cardiovascular
disease
(CVD).
Different
modes,
including
autophagy,
apoptosis,
pyroptosis,
are
mosaic
with
each
other
collaboratively
regulate
process
CVD.
This
review
summarizes
interaction
crosstalk
key
pathways
or
proteins
which
play
critical
role
entire
CVD
explores
specific
mechanisms.
Furthermore,
this
paper
assesses
interrelationships
among
these
three
deaths
reviews
how
they
By
understanding
modes
go
together
we
can
learn
about
CVD,
will
enable
us
to
identify
new
targets
for
preventing,
controlling,
treating
It
not
only
reduce
mortality
but
also
improve
quality
life.
Frontiers in Oncology,
Journal Year:
2023,
Volume and Issue:
13
Published: July 10, 2023
Triple-negative
breast
cancer
(TNBC)
is
one
of
the
deadliest
subtypes
(BC)
for
its
high
aggressiveness,
heterogeneity,
and
hypoxic
nature.
Based
on
biological
clinical
observations
TNBC
related
mortality
very
worldwide.
Emerging
studies
have
clearly
demonstrated
that
hypoxia
regulates
critical
metabolic,
developmental,
survival
pathways
in
TNBC,
which
include
glycolysis
angiogenesis.
Alterations
to
these
accelerate
stem
cells
(CSCs)
enrichment
immune
escape,
further
lead
tumor
invasion,
migration,
metastasis.
Beside
this,
also
manipulates
epigenetic
plasticity
DNA
damage
response
(DDR)
syndicate
progression.
Hypoxia
fundamentally
creates
low
oxygen
condition
responsible
alteration
Hypoxia-Inducible
Factor-1alpha
(HIF-1α)
signaling
within
microenvironment,
allowing
tumors
survive
making
them
resistant
various
therapies.
Therefore,
there
an
urgent
need
society
establish
target-based
therapies
overcome
resistance
limitations
current
treatment
plan
TNBC.
In
this
review
article,
we
thoroughly
discussed
plausible
significance
HIF-1α
as
a
target
therapeutic
regimens
such
chemotherapy,
radiotherapy,
immunotherapy,
anti-angiogenic
therapy,
adjuvant
therapy
photodynamic
adoptive
cell
combination
therapies,
antibody
drug
conjugates
vaccines.
Further,
reviewed
here
intrinsic
mechanism
existing
issues
targeting
while
improvising
strategies.
This
highlights
discusses
future
perspectives
major
alternatives
by
hypoxia-induced
signaling.
Molecular and Cellular Probes,
Journal Year:
2024,
Volume and Issue:
75, P. 101961 - 101961
Published: April 8, 2024
As
one
of
the
earliest
discovered
lncRNA
molecules,
H19
is
usually
expressed
in
large
quantities
during
embryonic
development
and
involved
cell
differentiation
tissue
formation.
In
recent
years,
role
tumors
has
been
gradually
recognized.
Increasing
evidence
suggests
that
its
aberrant
expression
closely
related
to
cancer
development.
LncRNA
as
an
oncogene
not
only
promotes
growth,
proliferation,
invasion
metastasis
many
tumors,
but
also
develops
resistance
treatment,
affecting
patients'
prognosis
survival.
Therefore,
this
review,
we
summarise
extensive
research
on
involvement
tumor
progression
discuss
how
H19,
a
key
target
gene,
affects
sensitivity
radiotherapy,
chemotherapy
immunotherapy
by
participating
multiple
cellular
processes
regulating
signaling
pathways,
which
provides
promising
prospect
for
further
into
treatment
cancer.
