Phytomedicine, Journal Year: 2024, Volume and Issue: 136, P. 156328 - 156328
Published: Dec. 15, 2024
Language: Английский
Signal Transduction and Targeted Therapy, Journal Year: 2024, Volume and Issue: 9(1)
Published: Jan. 8, 2024
Abstract Ischemia-reperfusion (I/R) injury paradoxically occurs during reperfusion following ischemia, exacerbating the initial tissue damage. The limited understanding of intricate mechanisms underlying I/R hinders development effective therapeutic interventions. Wnt signaling pathway exhibits extensive crosstalk with various other pathways, forming a network system pathways involved in injury. This review article elucidates signaling, as well complex interplay between and including Notch, phosphatidylinositol 3-kinase/protein kinase B, transforming growth factor-β, nuclear factor kappa, bone morphogenetic protein, N-methyl-D-aspartic acid receptor-Ca 2+ -Activin A, Hippo-Yes-associated toll-like receptor 4/toll-interleukine-1 domain-containing adapter-inducing interferon-β, hepatocyte factor/mesenchymal-epithelial transition factor. In particular, we delve into their respective contributions to key pathological processes, apoptosis, inflammatory response, oxidative stress, extracellular matrix remodeling, angiogenesis, cell hypertrophy, fibrosis, ferroptosis, neurogenesis, blood-brain barrier damage Our comprehensive analysis reveals that activation canonical promotes organ recovery, while non-canonical exacerbates Moreover, explore novel approaches based on these mechanistic findings, incorporating evidence from animal experiments, current standards, clinical trials. objective this is provide deeper insights roles its I/R-mediated processes dysfunction, facilitate innovative agents for
Language: Английский
Citations
165
Drug Design Development and Therapy, Journal Year: 2025, Volume and Issue: Volume 19, P. 185 - 200
Published: Jan. 1, 2025
Abstract: Cerebral ischemia-reperfusion injury (CIRI) is clinically characterized by high rates of morbidity, disability, mortality, and recurrence as well economic burden. The clinical manifestations CIRI are often accompanied gastrointestinal symptoms such intestinal bacterial dysbiosis bleeding. Gut microbiota plays an important role in the pathogenesis CIRI, its potential biological effects have received extensive attention. gut not only affects barrier function but also regulates immunity host homeostasis. Traditional Chinese medicine (TCM), a multi-component multi-targeted drug, has shown remarkable few adverse reactions prevention treatment CIRI. Notably, effect TCM on regulating maintaining homeostasis gradually become hot topic. This review summarizes functional development progression therapeutic improving dysbiosis, affecting metabolism, immunity. active ingredients used for relevant studies were saponins, triterpenoids, phenolics, alkaloids. In addition, to treat briefly discussed. established significance prospects TCM-based treatments provided necessary theoretical support further resources Keywords: cerebral injury, ischemic stroke, gut-brain axis, microbiota, traditional
Language: Английский
Citations
1
Journal of Advanced Research, Journal Year: 2025, Volume and Issue: unknown
Published: Jan. 1, 2025
Language: Английский
Citations
1
Clinical Nutrition, Journal Year: 2024, Volume and Issue: 43(7), P. 1816 - 1831
Published: June 6, 2024
Language: Английский
Citations
6
Nanomedicine, Journal Year: 2024, Volume and Issue: 19(9), P. 811 - 835
Published: March 6, 2024
Ischemic stroke, prevalent among the elderly, necessitates attention to reperfusion injury post treatment. Limited drug access brain, owing blood–brain barrier, restricts clinical applications. Identifying efficient carriers capable of penetrating this barrier is crucial. Blood–brain transporters play a vital role in nutrient transport brain. Recently, nanoparticles emerged as carriers, enhancing permeability via surface-modified ligands. This article introduces structure, elucidates pathogenesis, compiles ischemic stroke treatment drugs, explores nanomaterials for encapsulation and emphasizes their advantages over conventional drugs. Utilizing drug-delivery systems offers targeting efficiency benefits absent traditional The prospects nanomedicine are promising.
Language: Английский
Citations
5
Journal of Ethnopharmacology, Journal Year: 2024, Volume and Issue: 329, P. 118157 - 118157
Published: April 6, 2024
Language: Английский
Citations
5
Mini-Reviews in Medicinal Chemistry, Journal Year: 2024, Volume and Issue: 24(18), P. 1701 - 1709
Published: March 14, 2024
Abstract:: Stroke is a well-known neurological disorder that carries significant morbidity and mortality rates worldwide. Cerebral Ischemic (CIS), the most common subtype of stroke, occurs when thrombosis or emboli form elsewhere in body travel to brain, leading reduced blood perfusion. Ischemia/Reperfusion Injury (CIRI) complication CIS arises flow rapidly restored brain tissue after period ischemia. The therapeutic approaches currently recognized for CIS, such as thrombolysis thrombectomy, have notable side effects limit their clinical application. Recently, there has been growing interest among researchers exploring potential herbal agents treating various disorders malignancies. One agent with medicinal applications tanshinone IIA, an active diterpene quinone extracted from Salvia miltiorrhiza Bunge. Tanshinone IIA shown several pharmacological benefits, including anti-inflammatory, antioxidant, anti-apoptotic, neuroprotective properties. Multiple studies indicated protective role CIRI. This literature review aims summarize current findings regarding molecular mechanisms through which this compound improves
Language: Английский
Citations
4
Natural Products and Bioprospecting, Journal Year: 2025, Volume and Issue: 15(1)
Published: Jan. 8, 2025
Abstract Anchusa italica Retz. (AIR), a traditional herbal remedy, is commonly applied in managing heart and brain disorders. However, its specific function mechanism acute cerebral ischemia–reperfusion injury (CIRI) are not fully understood. This research focused on the interventional effects potential mechanisms of AIR extract (AIRE) rat model CIRI. The was established using filament occlusion method, which involved blocking middle artery for 1.5 h then removing to restore blood flow. Transcriptomic metabolomic analyses were conducted explore molecular pathways metabolites affected by AIRE. ATP level measured an assay kit. Additionally, RT-qPCR western blot tests evaluate influence AIRE Wnt signaling pathway mitochondrial function. indicated that regulated CIRI modulated associated with energy metabolism, such as citrate succinate. result demonstrated enhanced production Further, revealed activated Wnt/β-catenin corrected dysfunction. These results proposed mitigated metabolism deficits via pathway. By restoring balance might offer potentially therapeutic strategy addressing Graphical
Language: Английский
Citations
0
Chemico-Biological Interactions, Journal Year: 2025, Volume and Issue: unknown, P. 111405 - 111405
Published: Jan. 1, 2025
Language: Английский
Citations
0
CNS Neuroscience & Therapeutics, Journal Year: 2025, Volume and Issue: 31(3)
Published: March 1, 2025
Post-cardiopulmonary resuscitation brain injury (PBI) is essentially the cerebral ischemia reperfusion (CIR) injury, which main cause of death and long-term disability in patients with cardiac arrest. So far, there no treatment for PBI; thus, it urgent to develop new drugs or therapies prevention after cardiopulmonary resuscitation. Although multiple constituent herbs active ingredients Xinbao Pill (XBP) have shown neuroprotective effects, whether XBP could play a therapeutic role on PBI still unknown. This study aimed illustrate effect probe underlying mechanisms. We first performed cell animal experiments validate protective neurological function. next identified potential differential metabolites via metabolomics analysis. further conducted comprehensive network pharmacology analysis including overlap gene analysis, protein-protein interaction network, gene-biological process-module function preliminarily investigate specific mechanism action (MOA) against PBI. Finally, PCR, MTT, ELISA assay, as well Western blotting were made our proposed molecular The vitro experiment showed that increase viability ameliorate morphological damage PC12 cells exposed oxygen-glucose deprivation reoxygenation (OGD/RO) conditions. vivo demonstrated improved Neurologic Deficit Score (NDS), lowered Neuron-Specific Enolase (NSE) level reversed typical neuropathological changes rats, indicating its Further 94 treatment, highly related CIR. Moreover, results revealed may be relevant mitochondrial quality control (MQC). Mechanistically, not only promote expressions marker proteins PGC1α, NRF1, TFAM, OPA1, MFN1 MFN2 biogenesis fusion but also inhibit those containing DRP1, MFF, FIS1, p62, PINK1, Parkin LC3 fission mitophagy. AMP-activated protein kinase (AMPK) inhibitor was crucial regulating MQC. Our determined might an anti-PBI formula, deciphered MOAs by approach combined experimental validation.
Language: Английский
Citations
0