Transcriptomics and proteomics provide insights into the adaptative strategies of Tibetan naked carps (Gymnocypris przewalskii) to saline-alkaline variations

BMC Genomics, Journal Year: 2025, Volume and Issue: 26(1)

Published: Feb. 19, 2025

Language: Английский

Lower Sphingomyelin SM 42:1 Plasma Level in Coronary Artery Disease—Preliminary Study

International Journal of Molecular Sciences, Journal Year: 2025, Volume and Issue: 26(4), P. 1715 - 1715

Published: Feb. 17, 2025

Coronary artery atherosclerosis is a common condition characterized by different symptomatology and incidences of risk factors. The disease manifestation may differ; therefore, proper diagnosis essential. preventive, diagnostic, therapeutic arms are still developing to improve patient outcomes. Among diagnostic steps, the non-invasive tools for evaluating non-classical factors related metabolomic profiles gaining attention. aim this study was investigate possible metabolic profiling differences between patients with chronic coronary (CAD) control group based on plasma sphingomyelin levels. consisted 23 (72% male, median age 69 (63-72) years) presenting syndrome confirmed epicardial in angiography 15 (33% 70 (64-72) normal angiographic results. Clinical data were recorded, blood samples collected standard biochemical laboratory assessment profiling. levels evaluated degrees involvement. In addition, severity estimated Gensini Score. subgroups did not differ terms (p = 0.765) co-morbidities, though male sex more CAD 0.007). analysis revealed significant regarding neutrophil count 0.014), neutrophil-to-lymphocyte ratio (NLR) 0.016), high-density lipoprotein (HDL) 0.003). species, there difference SM42:1 level (16.2 (14.2-19.1) vs. 20.8 (18.9-21.7) 0.044) groups, respectively. SM 42:1 independent number involved arteries 0.109). However, Spearman correlations tests performed diagnosed (rho -0.356, p 0.014) measured Score -0.403, 0.006). There no correlation NLR (Spearman's rho -0.135, 0.420), suggesting lack inflammatory associations. Further, sphingomyelins showed relationship such as dyslipidemia diabetes. Lower compared group, indicating significance progression.

Language: Английский

Granulosa cell RNA-Seq insights into senescence and sphingolipid metabolism disorder in PCOS: aspirin as a potential therapeutic drug

Reproductive Biology and Endocrinology, Journal Year: 2025, Volume and Issue: 23(1)

Published: April 26, 2025

Language: Английский