Diabetic Retinopathy (DR): Mechanisms, Current Therapies, and Emerging Strategies

Cells, Journal Year: 2025, Volume and Issue: 14(5), P. 376 - 376

Published: March 4, 2025

Diabetic retinopathy (DR) is one of the most prevalent complications diabetes, affecting nearly one-third patients with diabetes mellitus and remaining a leading cause blindness worldwide. Among various diabetes-induced complications, DR particular importance due to its direct impact on vision irreversible damage retina. characterized by multiple pathological processes, primarily hyperglycemia-induced inflammatory response oxidative stress. Current gold standard therapies, such as anti-VEGF injections photocoagulation, have shown efficacy in slowing disease progression. However, challenges drug resistance, partial therapeutic responses, reliance eye injections—which often result low patient compliance—remain unresolved. This review provides comprehensive overview underlying molecular mechanisms DR, current their unmet needs for treatment. Additionally, emerging strategies improving treatment outcomes are discussed.

Language: Английский

Integrating Resonance Energy Transfer with Redox Reaction for Highly Sensitive Electrochemiluminescence Sensing of Glucose

Published: Jan. 1, 2025

Language: Английский

Interpretable Machine Learning reveals the Role of PANoptosis in the Diagnosis and Subtyping of NAFLD

Immunobiology, Journal Year: 2025, Volume and Issue: unknown, P. 152909 - 152909

Published: April 1, 2025

Language: Английский