Euro-Mediterranean Journal for Environmental Integration, Journal Year: 2024, Volume and Issue: unknown
Published: Nov. 16, 2024
Language: Английский
Journal of Hazardous Materials Advances, Journal Year: 2025, Volume and Issue: unknown, P. 100588 - 100588
Published: Jan. 1, 2025
Language: Английский
Citations
6
Journal of Oral Biology and Craniofacial Research, Journal Year: 2025, Volume and Issue: 15(3), P. 563 - 569
Published: March 26, 2025
Language: Английский
Citations
1
Antioxidants, Journal Year: 2025, Volume and Issue: 14(4), P. 489 - 489
Published: April 18, 2025
Nanoparticles (NPs) have revolutionized biomedical and pharmaceutical applications due to their unique physicochemical properties. However, widespread use has raised concerns regarding potential toxicity, particularly mediated by oxidative stress mechanisms. This redox imbalance, primarily driven the overproduction of reactive oxygen species (ROS), plays a central role in NP-induced leading cellular dysfunction, inflammation, apoptosis, genotoxicity. Zebrafish (Danio rerio) emerged as powerful vivo model for nanotoxicology, offering advantages such genetic similarity humans, rapid development, optical transparency, allowing real-time monitoring damage. review synthesizes current findings on zebrafish, highlighting key toxicity mechanisms case studies involving metallic (gold, silver, copper), metal oxide (zinc oxide, titanium dioxide, iron oxide), polymeric, lipid-based NPs. The influence NP properties, size, surface charge, functionalization, responses is explored. Additionally, experimental approaches used assess ROS generation, antioxidant enzyme activity, damage biomarkers zebrafish models are examined. In addition concerns, antioxidant-modified NPs evaluated, drug delivery, neuroprotection, disease therapeutics. Notably, show that curcumin- quercetin-loaded nanoparticles enhance defense reduce neurotoxicity models, demonstrating promise neuroprotective therapies. Furthermore, cerium nanoparticles, which mimic catalase SOD enzymatic shown significant efficacy reducing protecting against Challenges zebrafish-based need standardized methodologies, future directions optimizing design minimize stress-related risks also discussed. By integrating insights from mechanisms, studies, strategies, this supports development safer more effective nanoparticle-based therapies while addressing challenges toxicity.
Language: Английский
Citations
0
BULLETIN OF STOMATOLOGY AND MAXILLOFACIAL SURGERY, Journal Year: 2025, Volume and Issue: unknown, P. 206 - 215
Published: March 20, 2025
Background: Wound healing is a complex biological process involving, proliferation, and tissue remodelling, requiring advanced biomaterials to facilitate effective regeneration. This study evaluated the wound potential of composite scaffolds incorporating Cissus quadrangularis extract, carrageenan, tendon extracellular matrix (ECM) with bioceramics such as silver hydroxyapatite tricalcium phosphate using zebrafish model. Materials Methods: The were extensively characterized Scanning Electron Microscopy (SEM), Fourier Transform Infrared Spectroscopy (FTIR), X- ray diffraction (XRD) determine their physiochemical properties correlation efficacy. wild- type wounded treated following negative control (Group 1), (TEM) 2), Group 3 (contained + 2 components), 4 (Silver components) respectively for 21 days. closure ratio was assessed on 0, 7 14 days histological observations. Results: As results, SEM analysis revealed highly porous architecture interconnected pores, enhancing cellular adhesion, migration at site. surface roughness provided an optimal microenvironment fibroblast infiltration re-epithelization, accelerating process. FTIR confirmed presence hydroxyl, carboxyl, amide, groups indicating strong biomaterial interactions, hydration, bioactivity. observed peaks validated incorporation essential calcium ion release osteogenic differentiation. XRD patterns exhibited well- defined crystalline corresponding bioactive glass, ensuring stability, controlled degradation, prolonged bioactivity Zebrafish assays demonstrated significant improvements in closure, reduced inflammation, enhanced remodelling scaffold groups. histology observations that treatment induced rapid epidermal formation, immune cell activity, vascularization. Faster contraction new scale formation post injury, highlighting scaffold’s effectiveness compared slower recovery untreated controls. combined effects synergistic approach Conclusion: application phosphate, C. quadrangularis, TEM effectively promoted healing. Future research should focus optimizing composition validating efficacy mammalian models translational applications
Language: Английский
Citations
0
Euro-Mediterranean Journal for Environmental Integration, Journal Year: 2024, Volume and Issue: unknown
Published: Nov. 16, 2024
Language: Английский
Citations
2