The recent development, application, and future prospects of muscle atrophy animal models DOI Creative Commons
Gongchang Zhang,

Fengjuan Hu,

Tingting Huang

et al.

MedComm – Future Medicine, Journal Year: 2024, Volume and Issue: 3(4)

Published: Dec. 1, 2024

Abstract Muscle atrophy, characterized by the loss of muscle mass and function, is a hallmark sarcopenia cachexia, frequently associated with aging, malignant tumors, chronic heart failure, malnutrition. Moreover, it poses significant challenges to human health, leading increased frailty, reduced quality life, heightened mortality risks. Despite extensive research on consensus in their assessment remains elusive, inconsistent conclusions regarding molecular mechanisms. atrophy models are crucial tools for advancing this field. Currently, animal used clinical basic scientific studies induced through various methods, including genetic editing, nutritional modification, exercise, wasting diseases, drug administration. also include vitro small organism models. value, each these has certain limitations. This review focuses limitations diverse applications understand encourage rational use future research, therefore deepening understanding underlying pathophysiological mechanisms, ultimately exploration therapeutic strategies cachexia.

Language: Английский

Structural characterizations and antiaging activities of hydrolyzed low-molecular-weight polysaccharides from Polygoni Multiflori Radix Praeparata DOI
Xu We, Xuejian Li,

Yu-Sen Zhong

et al.

Carbohydrate Polymers, Journal Year: 2025, Volume and Issue: 356, P. 123381 - 123381

Published: Feb. 14, 2025

Language: Английский

Citations

2
AMPK: The Energy Sensor at the Crossroads of Aging and Cancer DOI
Vasudevarao Penugurti, Rajesh Manne, Ling Bai

et al.

Seminars in Cancer Biology, Journal Year: 2024, Volume and Issue: 106-107, P. 15 - 27

Published: Aug. 26, 2024

Language: Английский

Citations

8
Key genes and processes affected by atorvastatin treatment in mouse diaphragm muscle DOI

Guzel F. Zakyrjanova,

Valeriya A Matigorova,

Eva A. Kuznetsova

et al.

Archives of Toxicology, Journal Year: 2025, Volume and Issue: unknown

Published: April 16, 2025

Language: Английский

Citations

0
Hidden pathway: the role of extracellular matrix in type 2 diabetes mellitus–related sarcopenia DOI Creative Commons
Yiping Sun, Zepeng Zhang, Yufeng Wang

et al.

Frontiers in Endocrinology, Journal Year: 2025, Volume and Issue: 16

Published: April 16, 2025

Type 2 diabetes mellitus-related sarcopenia (T2DMRS) is a common complication in elderly and advanced patients that affects long-term prognosis quality of life. Skeletal muscle the main unit glucose metabolism, it surrounded by extracellular matrix (ECM), which microenvironment acts as an efficient highway system. The ECM essential for cellular communication nutrient transport supports cell growth repair. When this "ECM highway" fails to function effectively because damage or blockage, development T2DMRS can be triggered exacerbated. In recent years, has been widely demonstrated play critical role insulin resistance skeletal regeneration. However, how remodeling components specifically mechanism action not scientifically described detail. review, we comprehensively summarize T2DMRS-related mechanisms remodeling, suggesting collagen integrins may potential therapeutic targets.

Language: Английский

Citations

0
SGLT2 inhibitors as a novel senotherapeutic approach DOI Creative Commons
Zeynep Elif Yeşilyurt, Ce Qi,

Yi-Chian Wang

et al.

npj Aging, Journal Year: 2025, Volume and Issue: 11(1)

Published: May 10, 2025

Abstract Cellular senescence is the permanent cessation of cell proliferation and growth. Senescent cells accumulating in tissues organs with aging contribute to many chronic diseases, mainly through secretion a pro-inflammatory senescence-associated secretory phenotype (SASP). Senotherapeutic (senolytic or senomorphic) strategies targeting senescent or/and their SASP are being developed prolong healthy lifespan treat age-related pathologies. Sodium-glucose co-transporter 2 (SGLT2) inhibitors new class anti-diabetic drugs that promote renal excretion glucose, resulting lower blood glucose levels. Beyond glucose-lowering effects, SGLT2 have demonstrated protective effects against cardiovascular events. Moreover, recently been associated inhibition senescence, making them promising therapeutic approach for aging. This review examines latest research on senotherapeutic potential inhibitors.

Language: Английский

Citations

0
The recent development, application, and future prospects of muscle atrophy animal models DOI Creative Commons
Gongchang Zhang,

Fengjuan Hu,

Tingting Huang

et al.

MedComm – Future Medicine, Journal Year: 2024, Volume and Issue: 3(4)

Published: Dec. 1, 2024

Abstract Muscle atrophy, characterized by the loss of muscle mass and function, is a hallmark sarcopenia cachexia, frequently associated with aging, malignant tumors, chronic heart failure, malnutrition. Moreover, it poses significant challenges to human health, leading increased frailty, reduced quality life, heightened mortality risks. Despite extensive research on consensus in their assessment remains elusive, inconsistent conclusions regarding molecular mechanisms. atrophy models are crucial tools for advancing this field. Currently, animal used clinical basic scientific studies induced through various methods, including genetic editing, nutritional modification, exercise, wasting diseases, drug administration. also include vitro small organism models. value, each these has certain limitations. This review focuses limitations diverse applications understand encourage rational use future research, therefore deepening understanding underlying pathophysiological mechanisms, ultimately exploration therapeutic strategies cachexia.

Language: Английский

Citations

0