The Potential Application of Resveratrol and Its Derivatives in Central Nervous System Tumors DOI Open Access
Agnieszka Nowacka, Martyna Śniegocka, Wojciech Smuczyński

et al.

International Journal of Molecular Sciences, Journal Year: 2024, Volume and Issue: 25(24), P. 13338 - 13338

Published: Dec. 12, 2024

Resveratrol, a naturally occurring polyphenolic compound found in various plants, has been extensively studied for its broad spectrum of beneficial biological effects. These encompass potent antioxidant properties, anti-inflammatory activities, anti-aging capabilities, cardioprotective functions, and neuroprotective potential. The diverse actions resveratrol extend beyond these well-established properties. It also exerts significant impact on metabolic processes bioavailability, critically, it demonstrates the ability to effectively traverse blood–brain barrier. This capacity penetrate central nervous system renders promising therapeutic agent management malignancies, as shown inhibit tumor cell proliferation, induce apoptosis, modulate key signaling cascades, such PI3K/Akt, JAK/STAT, NF-kB. multifaceted nature resveratrol’s effects, including influence physiological processes, underscores potential valuable option treatment tumors.

Language: Английский

The state of the art in anti-aging: plant-based phytochemicals for skin care DOI Creative Commons
Merve Tomaş, Deniz Günal‐Köroğlu, Senem Kamiloğlu

et al.

Immunity & Ageing, Journal Year: 2025, Volume and Issue: 22(1)

Published: Jan. 31, 2025

Phytochemicals help mitigate skin aging by scavenging free radicals, modulating key enzymatic pathways, and promoting the skin's structural integrity. Carotenoids, vitamins, essential fatty acids, phenolic compounds work acting as antioxidants, inhibiting enzymes like hyaluronidase, collagenase, elastase, which degrade structure, reducing levels of inflammatory markers (IL-6, IL-8, etc.) matrix metalloproteinases (MMP-1, MMP-2) linked to aging. Recent research highlights that plant-based phytochemicals can improve elasticity, reduce hyperpigmentation, prevent breakdown important proteins, support wound healing, making them valuable components for care treatments. This review explores multifaceted roles in maintaining improving health, highlighting their mechanisms action potential anti-aging innovations.

Language: Английский

Citations

1
AMPK: The Energy Sensor at the Crossroads of Aging and Cancer DOI
Vasudevarao Penugurti, Rajesh Manne, Ling Bai

et al.

Seminars in Cancer Biology, Journal Year: 2024, Volume and Issue: 106-107, P. 15 - 27

Published: Aug. 26, 2024

Language: Английский

Citations

8
Lycium barbarum glycopeptide ameliorates aging phenotypes and enhances cardiac metabolism by activating the PINK1/Parkin-mediated mitophagy pathway in D-galactose-induced mice DOI Creative Commons

Tianchan Peng,

Jian Xiang, Yun Tian

et al.

Experimental Gerontology, Journal Year: 2025, Volume and Issue: 200, P. 112686 - 112686

Published: Jan. 18, 2025

Aging is a complex biological process that disrupts tissue structure and impairs physiological function, which contributes to the development of age-related diseases such as cardiovascular disorders. However, effective treatment strategies are lacking. To investigate geroprotective effects Lycium barbarum glycopeptide (LbGp) its potential mechanisms in D-galactose-induced accelerated aging mouse model. Mice were subcutaneously injected with D-galactose (500 mg/kg/day) for 12 weeks induce aging, while LbGp was orally administered (100 throughout study. The assessed by behavioral tests, cardiac echocardiography, pathohistological transcriptomic analyses. Transmission electron microscopy used observe ultrastructure mitochondria. Mitochondrial stress assays JC-1 fluorescent probe conducted evaluate mitochondrial function. Flow cytometer western blot performed assess mitophagy flux. improved phenotypes mice, pronounced enhancement function compared neurocognitive skeletal muscle functions. Transcriptome analysis indicated ameliorated energy metabolism heart. revealed preserved structural integrity inner membrane. attenuated fission restored impaired PINK1/Parkin-mediated pathway caused cardiomyocytes. can ameliorate enhance activating mice. These findings underscore therapeutic agent aging-related diseases.

Language: Английский

Citations

0
Safety and Efficacy Evaluation of Composite Collagen in Human Infraorbital Anti-aging and Nude Mouse Skin Photoaging DOI
Tao Wang,

Aawrish Khan,

Lunli Gong

et al.

Aesthetic Plastic Surgery, Journal Year: 2025, Volume and Issue: unknown

Published: March 10, 2025

Language: Английский

Citations

0
Photoaging: Current Concepts on Molecular Mechanisms, Prevention, and Treatment DOI
Maria Kaltchenko,

Anna L. Chien

American Journal of Clinical Dermatology, Journal Year: 2025, Volume and Issue: unknown

Published: March 12, 2025

Language: Английский

Citations

0
The Chronobiological and Neuroprotective Mechanisms of Resveratrol in Improving Sleep DOI Creative Commons
Wenwen Zhu, Aihua Gong, Bin Zhang

et al.

Mediators of Inflammation, Journal Year: 2025, Volume and Issue: 2025(1)

Published: Jan. 1, 2025

According to statistics, more than one‐third of the global population currently experiences sleep problems, and about 10% adults have been diagnosed with insomnia, a proportion that is increasing annually. Most used insomnia medications are not specifically developed but discovered by chance, often resulting in unavoidable side effects like addiction. Thus, there an urgent need find safer effective therapeutic options. Resveratrol, natural polyphenolic compound, shows significant potential improving insomnia. Research its may be achieved through multiple biological processes, including antiapoptosis, antioxidant activity, anti‐inflammation, circadian rhythm regulation, modulation neurotransmitters (gamma‐aminobutyric acid (GABA), DA, 5‐HT, cortisol), increased levels neurotrophic factor BDNF. Additionally, resveratrol’s treatment closely linked SIRT1, AMPK, NF‐ κ B, mTOR, PI3K/Akt, MAPK pathways. This review summarizes mechanisms resveratrol treating provide researchers deeper understanding action, which can aid development novel targeted drugs offer innovative ideas methods for clinical treatment.

Language: Английский

Citations

0
Sirtuins as therapeutic targets in diabetes DOI
Kajetan Kiełbowski, Aleksandra Wiktoria Bratborska,

Estera Bakinowska

et al.

Expert Opinion on Therapeutic Targets, Journal Year: 2025, Volume and Issue: unknown

Published: March 21, 2025

Introduction Sirtuins (SIRTs) are NAD+-dependent deacetylases that mediate post-translational modifications of proteins. Seven members the SIRT family have been identified in mammals. Importantly, SIRTs interact with numerous metabolic and inflammatory pathways. Thus, researchers investigated their role disorders.

Language: Английский

Citations

0
Natural Compounds with Beneficial Effects on Skin Collagen Type I and Mechanisms of Their Action DOI Creative Commons

Wioleta Żynda,

Agnieszka Ruczaj, Anna Galicka

et al.

Antioxidants, Journal Year: 2025, Volume and Issue: 14(4), P. 389 - 389

Published: March 26, 2025

The skin, as the largest external organ, is exposed to many environmental factors, such sunlight and pollution, well some synthetic ingredients in cosmetic products used excess by most people of all ages throughout their lives. Under influence these factors with age, amount key building protein, collagen type I, decreases, which leads a deterioration appearance condition skin. Currently, when average life expectancy increases, esthetic aspect maintaining healthy skin are particularly important. In pharmaceutical industries, attempts have long been made prevent aging application containing natural compounds, mainly due high antioxidant activity. This review collects polyphenols, stimulating protective effects on I human fibroblasts, along description mechanisms action. Some them tested mice rats, clinical trials, cases, results very promising. Nevertheless, there still need for an intensification studies order determine appropriate dosage, safety, effectiveness.

Language: Английский

Citations

0
Nasturtium officinale Microshoot Culture Multiplied in PlantForm Bioreactor—Phytochemical Profiling and Biological Activity DOI Creative Commons
Marta Klimek-Szczykutowicz, Magdalena Anna Malinowska,

Aleksandra Gałka

et al.

Molecules, Journal Year: 2025, Volume and Issue: 30(4), P. 936 - 936

Published: Feb. 18, 2025

Nasturtium officinale R. Br. (watercress) is an endangered species with valuable pharmaceutical, cosmetic, and nutritional properties. The purpose of this work was to evaluate the phytochemical profile biological activity extracts from microshoot cultures grown in PlantForm bioreactors parent plant material. After 20 days cultivation, achieved best results both terms key active ingredient content activity. glucosinolates (GSL) by UHPLC-DAD-MS/MS method showed that dominant compounds were glucobrassicin (493.00 mg/100 g DW, 10 days) gluconasturtiin (268.04 days). highest total polyphenol (TPC) obtained after a 20-day growth period (2690 mg GAE/100 DW). Among polyphenols, vitro sinapinic acid (114.83 ferulic (87.78 antioxidant potential assessed ABTS DPPH assays observed for ethanol extracts. inhibiting hyperpigmentation (18.12%) anti-elastase (79.78%) aqueous extract N. cultures. inhibited bacteria, including Cutibacterium acnes (MIC = 0.625 mg/mL). Antioxidant tests chelating capacity iron ions Fe2+ face emulsion higher than control.

Language: Английский

Citations

0
Curcumin targets YAP1 to enhance mitochondrial function and autophagy, protecting against UVB-induced photodamage DOI Creative Commons
Quan Chen, Wenxin Lin, Yi Tang

et al.

Frontiers in Immunology, Journal Year: 2025, Volume and Issue: 16

Published: March 25, 2025

Background Ultraviolet B (UVB) radiation is a major environmental factor contributing to skin damage via DNA damage, oxidative stress, inflammation, and collagen degradation. It penetrates the epidermis, disrupts integrity, generates reactive oxygen species (ROS), activating pro-inflammatory pathways such as NF-κB AP-1, inducing matrix metalloproteinases (MMPs). These processes lead structural changes, pigmentation disorders like melasma. Cumulative from UVB also drives photocarcinogenesis, with nearly 90% of melanomas associated UV (UVR). Despite clinical interventions phototherapy antioxidants, effective treatments for UVB-induced remain limited due side effects efficacy issues. Methods This study investigates protective curcumin on using mouse irradiation model HaCaT cells exposed in vitro . Skin was assessed through histopathological immunohistochemical analyses. Cellular functional changes were evaluated assays cell viability, mitochondrial function, ROS levels, apoptosis. Transcriptomic analysis employed elucidate molecular mechanisms underlying curcumin’s post-UVB exposure. integrated approach provides comprehensive understanding molecular-level protection against damage. Results Curcumin significantly alleviated lesions inflammation vivo In , it mitigated enhancing viability while reducing apoptosis levels. revealed that upregulated YAP signaling autophagy suppressing IL-18 expression. Conclusion treatment markedly improved reduced epidermal thickness intervention including increased apoptosis, elevated enhanced inflammatory responses. demonstrated pathway inhibiting pathway. Further studies directly interacts YAP1, promoting autophagy, an effect blocked by YAP1 inhibitor Verteporfin. Additionally, enhances function maintaining integrity preventing release (mtDNA) (mtROS), thereby NLRP3/IL-18 activation.

Language: Английский

Citations

0