Berberine Extends Lifespan in C. elegans Through Multi-Target Synergistic Antioxidant Effects DOI Creative Commons

Yingshuo Bei,

Ting Wang, Shuwen Guan

et al.

Antioxidants, Journal Year: 2025, Volume and Issue: 14(4), P. 450 - 450

Published: April 9, 2025

Aging is a process of gradual functional decline in complex physiological systems and closely related to the occurrence various diseases. Berberine, bioactive alkaloid derived from Coptis chinensis (Huanglian), has emerged as promising candidate for anti-aging interventions. This study comprehensively investigated lifespan-extending effects molecular mechanisms berberine C. elegans through integrated approaches including lifespan assays, locomotor activity analysis, oxidative stress challenges, transcriptomic profiling. Furthermore, genetic models mutant transgenic worms were employed delineate their interactions with insulin/IGF-1 signaling (IIS) pathway. Our results demonstrate that extended mean wild-type by 27%. By activating transcription factors such DAF-16/FOXO, HSF-1, SKN-1/NRF2, upregulated antioxidant enzyme expression, reduced lipofuscin accumulation, improved resistance. Transcriptomic analysis revealed significant changes lipid metabolism-related genes, particularly pathways involving fatty acid synthesis, degradation, sphingolipid metabolism. These findings establish exerts multi-target coordinated activation stress-responsive metabolic optimization, providing mechanistic insights developing natural product-based geroprotective strategies.

Language: Английский

The interplay of senescence and MMPs in myocardial infarction: implications for cardiac aging and therapeutics DOI

Ashok Kumar Balaraman,

Abdulmalik Saleh Alfawaz Altamimi, M. Arockia Babu

et al.

Biogerontology, Journal Year: 2025, Volume and Issue: 26(1)

Published: Jan. 20, 2025

Language: Английский

Citations

1
From mechanisms to medicine: Ferroptosis as a Therapeutic target in liver disorders DOI Creative Commons
Yuqi He,

Yumeng Lin,

Jinfeng Song

et al.

Cell Communication and Signaling, Journal Year: 2025, Volume and Issue: 23(1)

Published: March 7, 2025

In recent 10 years, ferroptosis has become a hot research direction in the scientific community as new way of cell death. Iron toxicity accumulation and lipotoxicity are unique features. Several studies have found that is involved regulation hepatic microenvironment various metabolisms, thereby mediating progression related liver diseases. For example, NRF2 FSP1, important regulatory proteins ferroptosis, development tumors failure. this manuscript, we present mechanisms concern with addition, summarize clinical advances targeted therapy for We expect manuscript can provide perspective treatment

Language: Английский

Citations

0
Berberine Extends Lifespan in C. elegans Through Multi-Target Synergistic Antioxidant Effects DOI Creative Commons

Yingshuo Bei,

Ting Wang, Shuwen Guan

et al.

Antioxidants, Journal Year: 2025, Volume and Issue: 14(4), P. 450 - 450

Published: April 9, 2025

Aging is a process of gradual functional decline in complex physiological systems and closely related to the occurrence various diseases. Berberine, bioactive alkaloid derived from Coptis chinensis (Huanglian), has emerged as promising candidate for anti-aging interventions. This study comprehensively investigated lifespan-extending effects molecular mechanisms berberine C. elegans through integrated approaches including lifespan assays, locomotor activity analysis, oxidative stress challenges, transcriptomic profiling. Furthermore, genetic models mutant transgenic worms were employed delineate their interactions with insulin/IGF-1 signaling (IIS) pathway. Our results demonstrate that extended mean wild-type by 27%. By activating transcription factors such DAF-16/FOXO, HSF-1, SKN-1/NRF2, upregulated antioxidant enzyme expression, reduced lipofuscin accumulation, improved resistance. Transcriptomic analysis revealed significant changes lipid metabolism-related genes, particularly pathways involving fatty acid synthesis, degradation, sphingolipid metabolism. These findings establish exerts multi-target coordinated activation stress-responsive metabolic optimization, providing mechanistic insights developing natural product-based geroprotective strategies.

Language: Английский

Citations

0